Vol 67, No 6 (2012)
- Year: 2012
- Published: 23.06.2012
- Articles: 10
- URL: https://vestnikramn.spr-journal.ru/jour/issue/view/25
- DOI: https://doi.org/10.15690/vramn676
PROCEEDINGS OF THE RAMS PRESIDIUM
4-8
9-12
13-24
CURRENT MEDICINE
World level of competitiveness of national researches in the field of clinical medicine
Abstract
There is proposed formalization of concepts «world research level» and «leading scientific technological directions» of global science used in program documents which define main trends of reformation of Russian science. Use of bibliographic index as an example of «normalized citation in related area» for analyzing various subject areas for Russian clinic medicine it was shown that there is a different correlation of some areas of some national subject areas to their world levels. It was noted that it’s nevessary to develop national methodology of Russian science audit considering its national aspect which is a real problem while application world-acclaimed methods.
Keywords: russian science, reforming, global science, world level of researches, methods of evaluation, clinical medicine, research fronts.
27-35
NEUROLOGY: CURRENT ISSUES
HEME OXYGENASE-2 NEURONS BRAIN AND SPINAL CORD OF HUMAN
Abstract
Immune localization of heme oxygenase-2 in neurons of some nuclei of the spinal cord and brain stem in 6 men 18–44 years old who died from causes unrelated to injury of central nervous system was studied. Neurons with positive reaction are determined for all studied regions of the brain where their contents in various nuclei ranging from 0,5 to 16% of the total number of cells detected by methylene blue. In all the sensory nuclei there is a high proportion of small neurons with a high or moderate density of reaction produc deposits. Large cells of motor nuclei often exhibit negative or low intensive enzyme reaction.
36-41
MOLECULAR MECHANISMS OF DEVELOPMENT OF CEREBRAL TOLERANCE TO ISCHEMIA. PART 1
Abstract
In the first part of this review molecular mechanisms of ischemic tolerance emerging as a result of preconditioning of the brain are discussed. Data on inductors, sensors, transducers and effectors of early and delayed ischemic tolerance are presented.
42-50
HEALTH CARE MANAGEMENT: CURRENT ISSUES
OCCUPATIONAL RISK MANAGEMENT: PROGNOSIS, CAUSATION AND BIOINFORMATIONAL TECHNOLOGIES
Abstract
Methodology of occupational risk management is outlined based on workers’ health disorders forecast and causation (work-relatedness assessment). It originates from Labour Code of Russian Federation prescriptions and includes principles, methods and criteria of risk management and risk communication. The methodology is realized by means of bioinformational technologies as expert and analytical system in the form of interactive Web-based directory «Occupational risk assessment» for practical use for occupational risk prevention.
51-56
TRANSLATIONAL MEDICINE AS A WAY FROM FUNDAMENTAL BIOMEDICAL SCIENCE TO PUBLIC HEALTH SERVICES
Abstract
Increasing distance between practical public health services and collecting of theoretical information in the field of biomedical researches reflects the necessity of professional contact between clinicians and scientists in many areas associated with medicine for active carrying over («translation») of the modern basic researches in which mechanisms of basic metabolic processes and possibilities of their correction are detected, to effective medical help to individual patient, i.e. personified medicine. Such approach was called transmitting medicine. Examples of the personified medicine in which biomedical researches together with the anamnesis morbi of individual patient that are responsible for treatment strategy including doses and regimens are discussed.
57-65
PHYSIOLOGY: CURRENT ISSUES
OXYGEN-TRANSPORT FUNCTION OF BLOOD AT PREGNANT, TRANSFERRED THE AGGRAVATION OF THE HERPESVIRUS INFECTION
Abstract
Factors which may influence on erythrocytes in peripheral blood while exacerbation of herpes infection are studied. The data showed that herpes infection changed quantative spectrum of proteins in erythrocytes. In cellular membranes of erythrocytes lipid peroxidation increases that results in increase of microviscosity of membranes. Disconnection of hemoglobin with 2, 3-DPhG was defined. This results in decreased hemoglobin oxygenation and change of erythrocytes form. The data showed that herpes virus in exacerbation leads to tissue hypoxia in pregnant women.
66-72
ENDOGENOUS OPIOID SYSTEM AS A MEDIATOR OF ACUTE AND LONG-TERM ADAPTATION TO STRESS. PROSPECTS FOR CLINICAL USE OF OPIOID PEPTIDES
Abstract
It has been well established that opioid peptides (OPs) affect various hormonal systems. Opioids exhibit stress-limiting and gastro-protective effects in stressed animals, acting via μ- and δ-opioid receptors (OR). Peripheral μ-OR stimulation by endogenous and exogenous opioids increases cardiac tolerance to pathological consequences of stress. Enhancement of prostacyclin synthesis, decrease of thromboxane production as well as suppression of lipid peroxidation can be directly responsible for cardioprotective effects of OPs in stressed animals. Adaptive responses are accompanied by increased OP levels in blood and tissues. Reduction of ventricular arrhythmias induced by repeated short-term immobilization stress is mediated via μ-OR stimulation by endogenous opioids, while δ-OR account for an antiarrhythmic effect of adaptation to chronic intermittent hypobaric hypoxia. The mechanism of infarct size-limiting effect of continuous normobaric hypoxia involves both μ- and δ-OR stimulation. Peptide OR agonists can be considered in future clinical practice for treatment of withdrawal syndrome, stress-related cardiac disease or myocardial injury caused by ischemia-reperfusion insult.
73-82