Annals of the Russian academy of medical sciences
https://vestnikramn.spr-journal.ru/jour
Annals of the Russian academy of medical sciences | Peer-rewieved medical journal"Paediatrician" Publishers LLCru-RUAnnals of the Russian academy of medical sciences0869-6047<h4>Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical<br />'Annals of the Russian Academy of Medical Sciences'</h4> <p align="left">"Paediatrician" Publishers LLC, represented by the Director general Teya Margiyeva, acting under by-laws, hereinafter referred to as the Publisher, on the one hand, hereby offers to the public at large, hereinafter referred to as the Author, on the other hand, hereinafter collectively referred to as the Parties, to enter into this agreement, hereinafter referred to as the Agreement, regarding publication of scholarly materials, hereinafter referred to as the Article, in the Journal named 'Annals of the Russian Academy of Medical Sciences', hereinafter referred to as the Journal, under the following terms.</p> <h4>1. General Terms and Conditions</h4> <p align="left">1.1. Pursuant to Clause 2 of the Article 437 of the Russian Federation Civil Code, this Agreement shall be recognized as the public offer, hereinafter referred to as the Offer. Subject to Article 438 of the Russian Federation Civil Code, this Offer shall be deemed to have been completely and irrevocably accepted after the Author had submitted his/her materials by uploading those onto the network electronic system of the article acquisition for review available at the respective section of the Journal's site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Information and Communication Network known as the Internet, hereinafter referred to as the Internet.</p> <p align="left">1.2. Pursuant to the Russian Federation effective law as applicable to compliance with the copyright to electronic information resources, no materials from any site, electronic journal or project may be reproduced, in whole or in part, in any form, either in a hard or soft copy, without a prior consent from the Journal's authors and editorial staff, which may be expressed by posting a respective consent (open license <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">Creative Commons Attribution International 4.0 CC-BY</a>) in the relevant section of the Journal's site on the Internet. Whenever any published materials are used within the context of other documents, a reference to the original source needs to be specified.</p> <p align="left">1.3. The Journal is registered by the Federal Oversight Service for Communications, Information Technologies and Mass Communications (RosKomNadzor).</p> <h4>2. Terms Used in This Agreement</h4> <ul> <li><strong>The Author</strong> is an individual (or individuals) whose creative labor has produced the Article.</li> <li><strong>The Offer Acceptance</strong> means a complete and irrevocable acceptance of the Offer under the terms specified in Clause 3 hereof (the Author accepts the Offer by submitting an application to the Publisher, i.e. by uploading the Article along with support materials onto the network electronic system of the article acquisition for review available at the respective section of the Journal's site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Internet).</li> <li><strong>The Journal</strong> means an academic periodical named 'Annals of the Russian Academy of Medical Sciences'.</li> <li><strong>The Application </strong>means an electronic request of the Author addressed to the Publisher for publishing the Article in the Journal by uploading the Article and support materials onto the network electronic system of the article acquisition for review available at the relevant section of the Journal's site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Internet).</li> <li><strong>The Publisher</strong> is the "Paediatrician" Publishers LLC.</li> <li><strong>The Article's Metadata </strong>means any materials in Russian and English intended to be included in the Science Citation database as per the original version of the Article such as the Article title; authors' details (full last name, first name, patronymic, present employer of each author with indication of the postal code, contact details (e-mail) of each author; abstract; keywords; topical classifications: UDC or any other bibliographic and library classification, and subject indices; bibliography (list of references).</li> <li><strong>The Offer</strong> means this document (offer to the Author) to publish an Article by uploading it onto the site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Internet.</li> <li><strong>The Publication </strong>means the act of publishing the Article in the Journal.</li> <li><strong>The Journal's Editorial Staff</strong> means a creative team engaged in preparing the Journal for publication.</li> <li><strong>The Editorial Board</strong> is an advisory body of the Journal's Editorial Office.</li> <li><strong>The Article</strong> means a result of fundamental and applied scholarly efforts in the form of a scholarly material, scientific review material, scientific message, bibliographical review on specific topics of the scholarly study, and background information on Russian and foreign scientists submitted by the Author for publication in the Journal.</li> <li><strong>The Parties </strong>mean the Author and the Publisher.</li> <li><strong>The Article Requirements </strong>mean requirements to the materials published in the Journal's section named "To Authors" of the Journal's site at <a href="/jour/about/submissions#authorGuidelines">http://vestnikramn.spr-journal.ru/jour/about/submissions#authorGuidelines</a> on the Internet.</li> <li><strong>The Service </strong>means publication of the Article in the Journal as per the Author's application.</li> </ul> <h4>3. Subject Matter of the Agreement (Offer)</h4> <p align="left">3.1. Subject to this Agreement, the Author shall provide the Publisher at no expense for the copyright duration as stated by the Russian Federation legislation with <strong>a non-exclusive license</strong> for use of the Author-created Article for the purpose of its publication in the Journal.</p> <p align="left">3.2. The rights to use this Article as assigned hereunder shall include but not limited to:</p> <ul> <li>reproduction of the Article or any part thereof, as well as its metadata in Russian and English in any material form whatsoever, including soft and hard copy forms, as an individual work product in periodicals and/or databases (whether local or web-based) owned by the Publisher and/or any other persons at the discretion of the Publisher;</li> <li>dissemination of the Article or any part thereof, as well as its metadata in Russian and English on any media as part of the Journal and/or databases owned by the Publisher or any other persons, at the discretion of the Publisher, or as an individual work product, worldwide via open access or by subscription without payment of any fee to the Author;</li> <li>making public the Article or any part thereof as well as its metadata in Russian and English so that any person could access the Article from any location and at any time of his/her choice (including via the Internet);</li> <li>issuing permissions to use the Article or any part thereof as well as its metadata in Russian and English to any third parties while notifying the Author by publishing the respective information on the Journal's site without payment of any fee to the Author;</li> <li>processing, including translation of the Article (including translation into foreign languages), and use of the processed (translated) Article in any manner specified above;</li> <li>any other rights, not expressly assigned to the Publisher hereunder, including patent rights to any processes, techniques or methods, and other means, described by the Author in the Article, as well as trademark rights, shall be retained by the Author.</li> </ul> <p align="left">3.3. No territorial restrictions will be applied to the use of rights to the Article.</p> <p align="left">3.4. This Agreement shall become effective from the time the Article is submitted to the Journal, i.e. uploaded along with support materials onto the network electronic system of the article acquisition for review available at the relevant section of the Journal's site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Internet, hereinafter referred to as the Article Upload.</p> <p align="left">3.5. The rights shall be assigned by the Author to the Publisher at no expense, and the Article publication in the Journal shall not result in any financial contribution to the Author.</p> <p align="left">3.6. If the Publisher decides to refuse to publish the Article in the Journal, this Agreement shall cease to be in force. A decision to refuse publication shall be sent to the Author via the e-mail address specified in the Application.</p> <p align="left">3.7. The Publisher undertakes, throughout the currency of this Agreement, to provide to the Author the services associated with the publication of the Article on the Journal's site at <a href="/">http://vestnikramn.spr-journal.ru/</a> on the Internet.</p> <h4>4. General Terms of the Services Provision</h4> <p align="left">4.1. The Publisher shall provide the services to the Author only if:</p> <ul> <li>the Author submits all materials compliant with the Offer requirements by way of the Article Upload;</li> <li>the Author Accepts the Offer.</li> </ul> <p align="left">4.2. The services shall be provided to the Author free of charge.</p> <p align="left">4.3. If any materials submitted by the Author are found in breach of rules and requirements of this Offer, the Publisher shall have a right to refuse to publish those.</p> <p align="left">4.4. The Publisher shall not be responsible for any third-party unauthorized use of the data provided by the Author during the currency of this Agreement.</p> <h4>5. Rights and Responsibilities of the Parties</h4> <p align="left">5.1. The Author warrants that:</p> <ul> <li>he/she is the valid holder of exclusive rights to the Article; rights granted to the Publisher hereunder were not earlier assigned and will not be assigned to any third parties prior to publication of the Article by the Publisher in the Journal;</li> <li>the Article contains all the references to cited authors and/or sources (materials) that are required by the effective copyright law;</li> <li>the Author has obtained all required licenses to results, facts and other borrowed materials used in the Article where the Author is not a copyright holder;</li> <li>the Article does not contain any materials that may not be published in public sources in accordance with the effective Russian Federation statutory instruments, and the Article publication and dissemination will not involve any disclosure of classified (confidential) information, including state secrets;</li> <li>the Author has advised other Co-authors of the terms of this Agreement and has received consents from all the Co-authors to conclude this Agreement under the terms hereunder.</li> </ul> <p align="left">5.2. The Author undertakes to:</p> <ul> <li>submit a manuscript of the Article as per the Requirements to articles;</li> <li>avoid using the soft copy of the Article produced by the Publisher for commercial purposes and in other periodicals;</li> <li>while preparing the Article for publication, the Author undertakes to:</li> <ul> <li>make edits specified by readers and approved by the Journal's Editorial Office in the text of the Article and/or revise the Article following the Publisher's request, where necessary;</li> <li>proofread the Article within the timeframes specified in the Journal publication schedule;</li> <li>make only such edits in the proof that are minimally required to correct errors made in the Article original and/or introduce factual and momentary changes.</li> </ul> </ul> <p align="left">5.3. The Author is entitled to:</p> <ul> <li>pass to any third party a soft copy of the published Article provided by the Publisher pursuant to Clause 5.4 hereof for the Article to be incorporated, in whole or in part, into a scientific information database or repository in order to promote academic or scholarly investigations or for informational and educational purposes subject to the Author, Journal and Publisher being properly referenced.</li> </ul> <p align="left">5.4. The Publisher undertakes to:</p> <ul> <li>publish the Author's Article, in soft or hard copy form, in the Journal in accordance with the terms hereof;</li> <li>provide the Author with the proof of the Article and make reasonable edits as requested by the Author, where required, following the Journal's Editorial resolution;</li> <li>provide the Author with the soft copy of the published Article by sending it to the Author's e-mail address within 15 business days of the Journal issue's publication;</li> <li>respect the Author's rights established by the effective law, protect those and use best endeavors to prevent any copyright infringements by third parties.</li> </ul> <p align="left">5.5. The Publisher is entitled to:</p> <ul> <li>carry out technical and literary editing of the Article such that its basic content would remain unchanged;</li> <li>review the Article and suggest appropriate changes to the Author, and elect not to publish the Article if the Author fails to introduce such changes;</li> <li>require from the Author and/or other persons that the Journal, Publisher, Author and any other copyright holder, as well as the title of the Article, Journal issue identification and a year of publication as specified in the Journal be properly referenced whenever the Journal and/or the Article, including any individual part or fragment thereof, are used by any of the above-mentioned individuals thereafter;</li> <li>publish preliminary and/or advertising information on the forthcoming publication of the Article in mass media and any other information sources;</li> <li>establish rules (conditions) for acceptance and publication of materials in the Journal. The Journal's Editorial Board, headed by the Editor-in-Chief, shall enjoy an exclusive right to accept and/or reject any materials submitted to the Journal's Editorial Office for publication purposes. No manuscript (tangible medium) submitted by the Author to the Journal's Editorial Office will be subject to return. The Journal's Editorial Staff will not enter into any correspondence regarding the rejection of the Article by the Journal's Editorial Board;</li> <li>suspend the provision of services to the Author hereunder temporarily for technical, technological and other reasons preventing the services from being provided for the duration of remedial activities;</li> <li>suspend services hereunder in accordance with civil procedures if:</li> <ul> <li>the Article does not correspond to the topics covered by the Journal or by any part thereof, or the submitted material is found insufficient for the individual publication, or the Article design is found at variance with the requirements imposed;</li> <li>the Author is in breach of any other obligations assumed under the Offer arrangement;</li> </ul> <li>introduce changes to the Offer as per the procedure established by the Offer.</li> </ul> <p align="left">5.6. Unless otherwise provided or stated herein, the Parties shall refer to the effective legislation of the Russian Federation.</p> <h4>6. Offer Acceptance and Conclusion of the Agreement. The Term of the Agreement</h4> <p align="left">6.1. This Agreement shall become effective when concluded, i.e. when the Author Accepts the Offer by sending an application to the Publisher, that is, by uploading the Article (Article Upload) and remain in effect for five years.</p> <p align="left">6.2. The Offer Acceptance constitutes an Agreement made in writing (Articles 438 and 1286.1 of the Russian Federation Civil Code) under the Offer terms.</p> <p align="left">6.3. Unless any of the Parties sends to the other Party a written notification of the Agreement termination no later than two months prior to the end of the specified five-year period, the duration of the Publisher's copyright to the Work shall be automatically extended for the similar period. The number of extensions is not limited.</p> <p align="left">6.4. The term of the Agreement may not exceed the duration of exclusive rights to the Article pursuant to the Russian Federation legislation.</p> <p align="left">6.5. Whenever the Author assigns (disposes of) his exclusive rights to the Work to any third party, this Agreement shall remain in effect.</p> <h4>7. Agreement Modification and Termination Procedure</h4> <p align="left">7.1. The Publisher shall have a right to unilaterally modify the terms of this Agreement by giving a prior notice to the Author, at least ten (10) calendar days before such modifications become effective, to the Author's e-mail address specified in the Author's application or via the Journal's site. These modifications shall become effective from the date specified in the respective notice.</p> <p align="left">7.2. If the Author disagrees with any modification in the terms of this Agreement, the Author shall have a right to submit a written notice of his/her withdrawal from this Agreement by uploading it onto the network electronic system of the article acquisition for review, available at the relevant section of the Journal's site at <a href="/index.php/jour/author/submit/">http://vestnikramn.spr-journal.ru/index.php/jour/author/submit/</a> on the Internet.</p> <p align="left">7.3. This Agreement may be terminated early:</p> <ul> <li>at any time by mutual agreement of the Parties; or</li> <li>otherwise as stipulated herein.</li> </ul> <p align="left">7.4. The Author shall have a right to cancel this Agreement unilaterally by sending the Publisher a respective notice in writing at least sixty (60) calendar days prior to the intended date of the Author's Article publication in the Journal.</p> <p align="left">7.5. The termination of this Agreement for any reasons shall not release the Parties from responsibility for breach of any Agreement terms during the currency hereof.</p> <h4>8. Liability</h4> <p align="left">8.1. A Party which has failed to perform its obligations under this Agreement, either in full or in part, shall be held liable pursuant to the Russian Federation legislation in force.</p> <p align="left">8.2. All the data provided by the Author shall be trustworthy. The Author shall be responsible for completeness and reliability of the data provided to the Publisher. The use of untrustworthy information obtained from the Author shall not entail any responsibility upon the Publisher for any adverse effects resulting from its actions based on such untrustworthy information.</p> <p align="left">8.3. The Author shall take full personal responsibility for compliance with the requirements of the Russian Federation law on advertising, protection of copyright and related rights, protection of trademarks and service marks, and protection of consumer rights.</p> <p align="left">8.4. The Publisher shall not be held responsible hereunder for:</p> <ul> <li>any actions resulting directly or indirectly from the actions of the Author;</li> <li>any loss incurred by the Author whether or not the Publisher was in a position to predict such loss.</li> </ul> <p align="left">8.5. The Publisher shall be relieved from any responsibility for non-compliance with the terms of this Agreement if such non-compliance is a result of a force-majeure event such as an act of state authorities, including adoption of legal instruments, fire, flood, earthquake, other natural calamities, loss of power and/or computer network failure, strikes, civil commotions, riots, and any other similar events.</p> <h4>9. Dispute Resolution Procedure</h4> <p align="left">9.1. Any disputes and disagreements shall be resolved by the Parties to negotiations, and if the Parties fail to reach an agreement, these shall be resolved in accordance with the effective law of the Russian Federation.</p> <p align="left">9.2. If any disagreements remain unresolved, the Parties shall settle those at the location of the Publisher in accordance with the effective law of the Russian Federation.</p> <h4>10. Miscellaneous</h4> <p align="left">10.1. Any notifications, messages, requests etc., excluding documents which need to be forwarded in original form pursuant to the Russian Federation legislation, shall be deemed to have been received by the Author, if delivered (sent) by the Publisher via the Journal's site, including by publishing those, by fax or e-mail specified in the Application, or using other communication facilities. The Parties acknowledge the validity of notifications, messages, requests etc. delivered (sent) using the above-listed methods.</p> <p align="left">10.2. Where the Publisher becomes subject to any claims related to non-compliance with an exclusive copyright or another intellectual property right of any third party during the writing of the Article or in connection with conclusion of this Agreement by the Author, the Author undertakes to:</p> <ul> <li>immediately upon receipt of a Publisher's notification, take measures to settle disputes with such third party, and, where necessary, join the litigation in favor of the Publisher and use its best endeavors to exclude the Publisher from the defendants;</li> <li>reimburse the legal cost, expenses and loss incurred by the Publisher as a result of application of a pre-award relief and measures for execution of a judgment, and damages paid by the Publisher to any third party for the infringement of exclusive copyright and/or other intellectual property rights, as well as other expenditures incurred by the Publisher as a result of infringement by the Author of any warranties provided hereunder.</li> </ul> <p align="left">10.3. Subject to Article 6 of the Federal Law On Personal Data No. 152-FZ dated July 27, 2006, for the period from the conclusion of this Agreement and until the discharge of Parties obligations hereunder, the Author expresses his/her consent to processing of the following personal data by the Publisher: last name, first name, patronymic; taxpayers identification number (TIN); place and date of birth; citizenship details; ID document details; registration and actual location address; e-mail address; mailing address with postal code; contact phone numbers; fax numbers; and details of the employers.</p> <p align="left">10.4. The Publisher is entitled to process the above personal data for the purpose of this Agreement performance, including for the provision of information and reference services to the Author. The processing of personal data shall be understood to mean any actions (operations) with personal data, including collection, systematization, accumulation, storage, refinement (update, alteration), use, distribution (including transfer to third parties), depersonalization, blocking and deletion of personal data in accordance with the effective Russian Federation legislation.</p> <p align="left">10.5. Where permitted by the Russian Federation legislation, the Author is entitled to withdraw his/her consent to the processing of personal data as listed in Clause 10.3 by forwarding a respective notice to the Publisher. Upon receipt of such notice, the Publisher has a right to suspend services.</p> <p align="left">10.6. The Author will, on a goodwill basis, submit his/her details (and details of each Co-Author subject to their prior consent) to the Journal's Editorial Office consisting of his/her: last name, first name, patronymic, academic rank, academic degree, job title, employer details (name and mailing address), work phone number and e-mail address for the purpose of its general publication in the Journal along with the Article.</p> <h4>11. Registered Address and Particulars of the Publisher</h4> <p align="left">"Paediatrician" Publishers LLC<br />Address: of. 17, 81-1 Vavilova street, 117335 Moscow, Russian Federation<br />TIN 7728798571, CRR 773601001, PSRN 1127746102780.<br />Phone: +7 (499) 134-07-30; +7 (499) 134-30-83 <br />Fax: +7 (499) 132-30-43 <br />E-mail: <a href="mailto:redactor@nczd.ru">r<span id="PH_user-email" class="x-ph__menu__button__text x-ph__menu__button__text_auth">vestnikramn@nczd.ru</span></a><br />WEB: <a href="/">http://vestnikramn.spr-journal.ru/</a></p>Sarcoidosis of the Skin as an Interdisciplinary Problem
https://vestnikramn.spr-journal.ru/jour/article/view/11602
<p>Sarcoidosis is a disease of unknown etiology characterized by the formation of epithelioid cell granulomas in several organs or tissues without caseous necrosis (fibrinoid necrosis may occur). With sarcoidosis, almost all organs and tissues can be affected, which determines the interdisciplinary nature of the problem. Skin sarcoidosis is one of the most common manifestations of systemic sarcoidosis. At the same time, the role of dermatologists in the diagnosis of sarcoidosis is exceptionally large, since skin lesions are often the key to the discovery of systemic sarcoidosis, which allows internists to purposefully and timely diagnose and treat lesions of internal organs. Skin rashes in patients with sarcoidosis may occur secondarily against the background of specific lesions of the lungs, intrathoracic nodes and other internal organs, however, skin sarcoidosis may also develop primarily. All forms of skin sarcoidosis may be the only manifestation of the disease, and it is impossible to distinguish clinically and histologically between skin changes in systemic sarcoidosis and skin lesions alone. Treatment of skin sarcoidosis often presents great difficulties and includes, depending on the prevalence and activity of the process, local (corticosteroids, tacrolimus) and systemic therapy (immunomodulators, immunosuppressors, TNF inhibitors).</p>Alexey V. SamtsovEvgeniy V. Kryukov
Copyright (c) 2024 "Paediatrician" Publishers LLC
2024-01-152024-01-1579151410.15690/vramn11602Autoimmune Skin Diseases in Multiple Sclerosis: Comorbidity Issues and the Impact of Pathogenetic Therapy
https://vestnikramn.spr-journal.ru/jour/article/view/12461
<p>The number of autoimmune diseases (AS), currently numbering more than 100 nosological forms, is constantly growing and is a significant problem of clinical medicine. Advances in the definition of diagnostic biomarkers and clinical tests make it possible in most cases to carry out differential diagnosis of autoimmune pathology and prescribe personalized immunocorrection. The modern understanding of the mechanisms of AS is based on the breakdown of tolerance to their own antigens, which occurs in genetically predisposed individuals against the background of impaired immunoregulation. In this review, using the example of multiple sclerosis (MS) as a classic AS of the nervous system, a possible combination of common autoimmune mechanisms of MS and such common skin diseases as psoriasis and atopic dermatitis is considered. Advances in the field of pharmacy have accelerated the path from the creation of new molecules to the introduction of modern pathogenetic drugs into daily clinical practice. To prevent exacerbations and progression of MS, disease-modifying therapy of MS are currently used. This treatment is permanent and long-term, and it is very important to take into account the comorbid pathologies that develop against the background of this therapy. The review shows the effect of DMT on the manifestation of skin diseases. The use of modern bioengineered drugs can contribute both to the activation and emergence of new diseases, and to stabilize the patient’s condition in the presence of autoimmune comorbidity.</p>Anton S. DvornikovEvgeny I. GusevMichail Yu. MartynovNatalia Yu. LashchTatyana A. GaydinaAnna S. ChukanovaAlexey N. Boyko
Copyright (c) 2024 "Paediatrician" Publishers LLC
2024-01-152024-01-15791152210.15690/vramn12461Influence of Migration on the Situation with Syphilis in the Russian Federation
https://vestnikramn.spr-journal.ru/jour/article/view/12993
<p>Syphilis is a socially significant disease, and the relevance of monitoring its incidence rates remains constant. The spread and level of syphilis morbidity in the Russian Federation is strongly influenced by migration processes. Over the last 7 years the migration flow in the country has increased by 17.5% and the number of migrant workers, them has increased 3 times. It is contingent of people, that being a “vulnerable group”, and most off all exposed to risky sexual behavior and STI infection. In 2021 and 2022 there was a significant increase in the incidence of syphilis in the Russian Federation, compared to 2020 — by 69.7%. The increase in the incidence of syphilis is largely due to the growth of this indicator among foreign citizens (from 2801 cases in 2020 to 12 748 cases in 2022). The proportion of registered cases of syphilis among foreign citizens in 2022 was 45.9% of all detected cases, while 80% of syphilis patients were citizens of one of 3 countries — Kyrgyz Republic (30%), Republic of Uzbekistan (27%), Republic of Tajikistan (23%). In the structure of clinical forms of syphilis detected in foreign citizens 98% are hidden and unspecified forms of the disease, only 13% of migrants with syphilis were treated and 87% have no information about the fact of treatment. Thus, latent forms of the disease and low percentage of treated foreign citizens with diagnosed syphilis have a negative impact on the epidemiological situation of syphilis incidence. These facts testify to the formation of risks of epidemiological danger of syphilis among foreigners entering the territory of the country, which poses a direct threat to biological security of the Russian Federation and requires the development of a set of measures to prevent the spread of the disease.</p>Margarita R. RakhmatulinaElena Yu. NovoselovaLidia E. MelekhinaAlexey A. Kubanov
Copyright (c) 2024 "Paediatrician" Publishers LLC
2024-01-152024-01-15791233210.15690/vramn12993The Theory of Self-Regulation of Parasitary Systems and COVID-19
https://vestnikramn.spr-journal.ru/jour/article/view/11607
<p><strong>Background</strong><strong>.</strong> The COVID-19 pandemic once again confirmed the correctness of the theory of Academician V.D. Belyakov, according to which the basis for the development of the epidemic process is a phase change in the heterogeneity of the biological properties of the interacting populations of the pathogen and humans. In accordance with the theory of self-regulation of parasitic systems, changes are associated not only with genetic variability, but also with other polydeterminant characteristics of the pathogen: when new genovariants appeared, SARS-CoV-2 became less pathogenic for humans, but more contagious. This circumstance is important not only for theoretical, but also for practical epidemiology, as it makes it possible to predict the direction of development of the epidemic situation.</p> <p><strong>Aims </strong>— to evaluate the manifestations of the epidemic process of the new coronavirus infection COVID-19 through the prism of the theory of self-regulation of parasitic systems.</p> <p><strong>Methods</strong><strong>.</strong> An epidemiological retrospective analysis of the incidence of COVID-19 was carried out, including the study of absolute and intensive incidence rates per 100,000 population, the dynamics of changes in the properties of the coronavirus population, and the identification of SARS-CoV-2 genovariants for the period from 03.2020 to 04.2023. To analyze SARS-CoV-2 genovariants at various stages of the pandemic, we used sequencing data presented on the SARS-CoV-2 genome information aggregation platform Virus Genome Aggregator of Russia (VGARus) — more than 248 thousand genetic sequences.</p> <p><strong>Results</strong><strong>. </strong>During the pandemic, there have been seven ups and downs in the incidence of COVID-19. During the period of circulation in the human population and adaptation to a new host, a significant amount of data has accumulated on the evolutionary changes in the SARS-CoV-2 genome, taking into account the trends in the acquisition of new epidemiological properties.</p> <p><strong>Conclusion</strong><strong>. </strong>An analysis of the manifestations of the epidemic process of COVID-19, as a classic aerosol anthroponosis, confirmed the correctness of the theory of Academician V.D. Belyakov, according to which the basis of its development is a phase change in the heterogeneity of the biological properties of the interacting populations of the pathogen and humans, based on negative feedback in the process of self-regulation.</p>Vasily G. AkimkinTatiana A. SemenenkoDmitry V. DubodelovKamil F. KhafizovSvetlana V. Ugleva
Copyright (c) 2024 "Paediatrician" Publishers LLC
2024-01-152024-01-15791334110.15690/vramn11607Analysis of the Risk of COVID-19 in the Post-Vaccination Period Based on the Results of a Multicenter Study — a Survey of Medical Workers
https://vestnikramn.spr-journal.ru/jour/article/view/13998
<p><strong>Background</strong><strong>.</strong> One of the vulnerable categories of the population during the COVID-19 pandemic has become employees of medical and educational institutions. Timely and properly organized prevention, based on anti-epidemic measures based on vaccination, is necessary not only to reduce the incidence of the disease, but primarily to reduce the severity in case of its occurrence, reduce the risk of hospitalization. Understanding the effectiveness of preventing SARS-CoV-2 infections among healthcare workers is a critical component of occupational health and safety policy and strategy.</p> <p><strong>Aim</strong><strong> —</strong> analysis of the incidence of COVID-19 after vaccination among medical staff and teaching staff of medical higher educational institutions.</p> <p><strong>Methods</strong><strong>.</strong> In the period from January to March 2022, a cross-sectional retrospective single-stage online study was conducted (anonymous questionnaires posted on the Anketologist platform). The survey was completed by 6032 respondents (82% efficiency). According to the criteria, 2114 respondents were excluded from the study. The analysis was carried out according to the questionnaires of 3918 respondents, including an assessment of the incidence after vaccination (n = 3668 respondents).</p> <p><strong>Results</strong><strong>. </strong>Fell ill after a double vaccination for 5 months — 663 (16.9%). Unvaccinated respondents reported that within 5 months. prior to the survey, 116 (46.4%) had a laboratory-confirmed new coronavirus infection. Lack of vaccination increased the risk of SARS-CoV-2 (OR 1.78 ± 0.14; 95% CI: 1.34–2.36). Efficiency within 5 months post-vaccination period was 55.5% (95% CI: 42.2–57.7%) for Sputnik V; 71.9% (95% CI: 68.1–85.4%) — Sputnik Light. It was found that gender and age were not a risk factor for the onset of the disease in the post-vaccination period. The presence of a history of previous COVID-19 increased the risk of disease in the post-vaccination period in individuals under 35 years of age (OR 2.323 ± 0.102; 95% CI: 1.903–2.836), aged 36–64 years (OR 2.547 ± 0.086; 95% CI: 2.150–3.016), older than 65 years (OR 1.323 ± 0.280; 95% CI: 0.764–2.290). Respondents with a history of a combination of chronic cardiovascular pathology and past COVID-19 had a higher risk of getting sick in the post-vaccination period (OR 1.338 ± 0.160; 95% CI: 0.977–1.832).</p> <p><strong>Conclusion</strong><strong>. </strong>According to the questionnaire, an important factor affecting the risk of COVID-19 in the post-vaccination period is the presence of SARS-CoV-2 before vaccination, which can increase the chance of developing the disease in the presence of other risk factors (chronic pathology, age, smoking, alcohol consumption).</p>Evgeniya A. MedvedevaKirill A. ZykovHerman G. MarinAntonina A. PloskirevaOksana A. SvitichAlla N. KairaDmitry A. NazarovIgor O. VolynkovAlexander A. KuzinAnatoliy V. KubyshkinAlexey V. TutelyanValery V. BeregovykhTatyana A. Chebotareva
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2024-01-152024-01-15791425110.15690/vramn13998Electrical Instability of the Myocardium in Children and Adolescents
https://vestnikramn.spr-journal.ru/jour/article/view/13996
<p>Currently, there is no doubt that the problem of electrical instability of the myocardium in pediatric cardiology is relevant. The determination of various indicators of electrical instability of the myocardium, which are predictors of life-threatening rhythm disorders and sudden cardiac death, presents an underdeveloped task not only for functional diagnostics specialists, but also for pediatricians, neonatologists, pediatric cardiologists and doctors of other specialties. Non-invasive research methods such as electrocardiography (ECG), Holter ECG monitoring (HM ECG), available in almost all pediatric treatment and prevention institutions, are quite informative in terms of detecting electrophysiological heterogeneity of the myocardium as a predictor of sudden cardiac death, which is especially important in children at risk, as well as young athletes. Thus, the determination of indicators of electrical instability of the myocardium is of great interest, it is a promising direction in modern clinical practice, allowing to predict the risk of developing fatal arrhythmias in children and adolescents.</p>Larisa A. BalykovaMarina V. ShirmankinaStanislav A. IvyanskiyAnna V. KrasnopolskayaDenis O. VladimirovTatyana S. ShablinovaEvgenia N. Tyagusheva
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2024-01-152024-01-15791525910.15690/vramn13996Overweight and Obesity in Children as Predictors of Early Puberty: A Meta-Analysis
https://vestnikramn.spr-journal.ru/jour/article/view/8810
<p><strong>Background</strong><strong>.</strong> Obesity and overweight among children remains to be an actual problem. To date, the relationship between them and puberty has not been determined. Objective — to estimate the overweight and obesity impact on puberty in boys and girls.</p> <p><strong>Methods</strong><strong>.</strong> The search for relevant sources was carried out in the Medline/PubMed, Researchgate, Elibrary, www.clinicaltrials.gov, www.clinicaltrialresults.org databases for the period from 2000 to 2023. Nine studies with a total of 24, 542 participants aged 0 to 18 years were selected for inclusion in the meta-analysis.</p> <p><strong>Results</strong><strong>. </strong>A significant relationship was established between precocious puberty in overweight/obese girls OR 2.23 (CI 1.63–3.05; p < 0.00001) and a tendency to accelerated puberty in boys OR 1.43 (CI 0.92–2.23; p = 0.11).</p> <p><strong>Conclusion</strong><strong>. </strong>Overweight and obesity in children are determinants of faster rates of puberty, in particular among girls.</p>Olga P. KovtunTatyana O. BrodovskayaMargarita A. Ustyuzhanina
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2024-01-152024-01-15791606910.15690/vramn8810Early Postoperative Complications after Pelvic Exenteration
https://vestnikramn.spr-journal.ru/jour/article/view/9193
<p><strong>Background</strong><strong>.</strong> Radiation therapy is an integral part of the treatment of most malignant neoplasms of the pelvic organs, which in 25–30% of cases can cause the development of late radiation complications; in addition, 2–8% of patients have severe complications with an outcome in fistulas of various localization. Also, tumors of this localization are prone to local-regional recurrence, which can be combined with late radiation injuries. One of the most radical, and, often, the only method of treating this extremely severe and prognostically unfavorable pathology is to perform evisceration of the pelvic organs; however, its implementation against the background of radiation damage to normal tissues, leading to a significant decrease in the reparative potential, inevitably leads to a high risk of postoperative complications.</p> <p><strong>Methods</strong><strong>.</strong> A retrospective analysis of early postoperative complications on the Clavien–Dindo scale was carried out in 136 patients after pelvic evisceration performed at the A.F. Tsyba MRSC in 2019–2021. All patients in the perioperative period underwent complex conservative therapy, including nutritional support.</p> <p><strong>Results</strong><strong>. </strong>Pelvic evisceration was performed due to the progression of the underlying disease in 57% of cases, in 29% — due to the development of severe late radiation injuries with an outcome in the fistula, in 14% — due to a combination of local recurrence of the underlying disease with radiation complications). Complications of grade I on the Clavien–Dindo scale were noted in 50%; II — in 20.5%; III — in 3.6%; grade IV — in 3%. There were no cases of postoperative mortality.</p> <p><strong>Conclusions. </strong>Conducting active preoperative preparation of patients aimed at correcting anemia, dysproteinemia, pain syndrome, etc.; as well as modifying surgical techniques and improving the management tactics of postoperative patients can minimize the risk of postoperative complications in patients after pelvic evisceration.</p>Valery A. KorotkovLeonid O. PetrovAleksandr L. PotapovVeronika N. ShitarevaVitaly Yu. SkoropadPavel V. SokolovMaksim R. KasymovVictor V. PasovLilia V. TivkovaAnastasia S. YamshikovaSergey A. IvanovAndrey D. Kaprin
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2024-01-152024-01-15791707610.15690/vramn9193Ectopic ACTH Syndrome: Possibilities of Modern Diagnostics
https://vestnikramn.spr-journal.ru/jour/article/view/12677
<p>The ectopic ACTH syndrome (EAS) is a constellation of clinical signs and symptoms caused by chronic excess production of cortisol by the adrenal glands due to stimulation by adrenocorticotropic hormone (ACTH) of extrapituitary origin. EAS is a rare pathology, it accounts for approximately 20% of all cases of ACTH-dependent hypercortisolism and up to 10% of all causes of endogenous autonomic cortisol production, however, it is often associated with severe hypercortisolism and is a life-threatening condition. The sources of ectopic secretion of ACTH are neuroendocrine tumors (NET), which differ in histological type, malignant potential, clinical course, and also have different, often difficult to detect localization. Early identification of ACTH -producing NET reduces the risk of death of the patient both from severe hypercortisolism and the tumor itself. The paper describes the features of the course of EAS, the possibilities of its diagnosis, and presents an algorithm for EAS diagnosis, created on the basis of the latest achievements of Russian and world medicine.</p>Elena N. GrinevaUliana A. TsoyDaria V. Ryzhkova
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2024-01-152024-01-15791778610.15690/vramn12677To the 75th Anniversary of Academician of the Russian Academy of Sciences Valery Ivanovich Sergienko
https://vestnikramn.spr-journal.ru/jour/article/view/17934
<p>January 5, 2024 marked the 75th anniversary of the birth of Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences Valery Ivanovich Sergienko, a leading Russian specialist in the field of physico-chemical medicine.</p>Alexander M. Dygai
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2024-01-152024-01-15791878810.15690/vramn17934To the 75th Anniversary of Academician of the Russian Academy of Sciences Gennady Petrovich Kotelnikov
https://vestnikramn.spr-journal.ru/jour/article/view/17943
<p>On January 11, 2024, the largest scientist in the field of traumatology and orthopedics, a talented organizer of healthcare and higher education, a public figure, laureate of the State Prize of the Russian Federation in the field of science and technology, three times laureate of the Government of the Russian Federation, Honored Scientist of the Russian Federation, academician, turned 75 RAS to Gennady Petrovich Kotelnikov.</p>Igor V. ReshetovNatalia I. UsoltsevaNatalia V. SergeevaAlexei A. Serikov
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2024-01-152024-01-15791899110.15690/vramn17943To the 75th Anniversary of Academician of the Russian Academy of Sciences Leyla Vladimirovna Adamyan
https://vestnikramn.spr-journal.ru/jour/article/view/17939
<p>January 20, 2024 marked the 75th anniversary of the birth of the largest specialist and outstanding scientist in the field of obstetrics and gynecology, laureate of the Government of the Russian Federation in the field of science and technology, full Knight of the Order of Merit for the Fatherland, Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences Leyla Vladimirovna Adamyan.</p>Igor V. ReshetovNatalia I. UsoltsevaNatalia V. SergeevaAlexei A. Serikov
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2024-01-152024-01-15791929310.15690/vramn17939To the 85th Anniversary of Academician of the Russian Academy of Sciences Valery Konstantinovich Leontiev
https://vestnikramn.spr-journal.ru/jour/article/view/17942
<p>On January 24, 2024, the largest scientist in the field of dentistry, an outstanding organizer of health care at the state level, laureate of the State Prize of the Russian Federation in the field of science and technology, Honored Scientist of the Russian Federation, Academician of the Russian Academy of Sciences Valery Konstantinovich Leontiev, turned 85 years old.</p>Igor V. ReshetovNatalia I. UsoltsevaNatalia V. SergeevaAlexei A. Serikov
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2024-01-152024-01-15791949510.15690/vramn17942