ENDOGENOUS OPIOID SYSTEM AS A MEDIATOR OF ACUTE AND LONG-TERM ADAPTATION TO STRESS. PROSPECTS FOR CLINICAL USE OF OPIOID PEPTIDES

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Abstract

It has been well established that opioid peptides (OPs) affect various hormonal systems. Opioids exhibit stress-limiting and gastro-protective effects in stressed animals, acting via μ- and δ-opioid receptors (OR). Peripheral μ-OR stimulation by endogenous and exogenous opioids increases cardiac tolerance to pathological consequences of stress. Enhancement of prostacyclin synthesis, decrease of thromboxane production as well as suppression of lipid peroxidation can be directly responsible for cardioprotective effects of OPs in stressed animals. Adaptive responses are accompanied by increased OP levels in blood and tissues. Reduction of ventricular arrhythmias induced by repeated short-term immobilization stress is mediated via μ-OR stimulation by endogenous opioids, while δ-OR account for an antiarrhythmic effect of adaptation to chronic intermittent hypobaric hypoxia. The mechanism of infarct size-limiting effect of continuous normobaric hypoxia involves both μ- and δ-OR stimulation. Peptide OR agonists can be considered in future clinical practice for treatment of withdrawal syndrome, stress-related cardiac disease or myocardial injury caused by ischemia-reperfusion insult.

 

About the authors

Yu. B. Lishmanov

Institute of Cardiology of the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia
Tomsk State Pedagogical University, Tomsk, Russia

Author for correspondence.
Email: zamdir@cardio.tsu.ru
доктор медицинских наук, профессор, член-корр. РАМН, заместитель директора по НИР ФГБУ «НИИ кардиологии» СО РАМН, главный научный сотрудник Томского государственного педагогиче- ского университета Адрес: 634012, Томск, ул. Киевская, д. 111 Тел.: (3822) 55-82-98 Россия

L. N. Maslov

Institute of Cardiology of the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia
Tomsk State Pedagogical University, Tomsk, Russia

Email: maslov@cardio.tsu.ru
доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии ФГБУ «НИИ кардиологии» СО РАМН, ведущий научный сотрудник Томского государственного педа- гогического университета Адрес: 634012, Томск, ул. Киевская, д. 111 Тел.: (3822) 26-21-74 Россия

N. Yu. Naryzhnaya

Institute of Cardiology of the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia
Tomsk State Pedagogical University, Tomsk, Russia

Email: natalynar@yandex.ru
кандидат медицинских наук, старший научный сотрудник лаборатории экспе- риментальной кардиологии ФГБУ «НИИ кардиологии» СО РАМН, старший научный сотрудник Томского государ- ственного педагогического университета Адрес: 634012, Томск, ул. Киевская, д. 111 Тел.: (3822) 26-21-74 Россия

J.-M. Pei

Department of Physiology, Fourth Military Medical University, Xi'an, Shaanxi Province, China

Email: Jmpei8@fmmu.edu.cn
профессор, Department of Physiology, Fourth Military Medical University Адрес: №169, West Changle Road, Xi’an 710032, Shaanxi Province, China Китай

F. Kolar

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Email: kolar@biomed.cas.cz
профессор, заведующий отделом, Dep. Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Адрес: Republic, Videnska 1083, 14220 Prague 4, Czech Republic Тел.: +420 24106 2125 Чехия

Y. Zhang

Hebei Medical University, Shijiazhuang, Hebei Province, China

Email: zhyhenry@hotmail.com
профессор, Ph D, Director of Department of Physiology Hebei Medical University Адрес: №361 East zhongshan Road Shijiazhuang 050017, China Китай

A. G. Portnichenko

Institute of Physiology NAS of Ukraine, Kiev, Ukraine

Email: port@serv.biph.kiev.ua
кандидат медицинских наук, старший научный сотрудник отдела общей и молеку- лярной патофизиологии Института физиологии им. А.А. Богомольца НАН Украины Адрес: 01024, Киев, ул. Богомольца, д. 4 Тел.: +38(044) 256 2061 Украина

H. Wang

Liaoning Medical College, Jinzhou city, Liaoning Province, China

Email: jyhxwang@163.com
профессор, Department of Pharmacology, Liaoning Medical College Адрес: № 40, Section 3, Songpo Road, Jinzhou city, Liaoning Province, China Китай

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