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Вестник Российской академии медицинских наук

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УФ-излучение как фактор риска немеланомного рака кожи. Генетические детерминанты онкогенеза

https://doi.org/10.15690/vramn941

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Аннотация

В обзоре представлены современные данные о роли ультрафиолетового излучения (УФ) в патогенезе немеланомного рака кожи, в частности изучена проблема развития плоскоклеточного и базальноклеточного рака кожи в популяции и при многокурсовом применении методов фототерапии (ПУВА, УФВ, УФВ-311) у больных псориазом. Рассматриваются механизмы УФ-индуцированного повреждения клетки разными спектральными диапазонами (УФА, УФВ), такие как формирование фотопродуктов, повреждение геномной ДНК и других клеточных структур, нарушение регуляции сигнальных путей, развитие хронического воспаления, вторичной иммуносупрессии. Обобщены результаты крупных эпидемиологических исследований, где обсуждается роль полиморфизмов гена гомологичной репарации ДНК XRCC3, гена теломеразы TERT-CLPTMI, гена цитокина IL10, гена MTHFR, кодирующего синтез фолатов, а также генов, участвующих в пигментообразовании (MC1R, EXOC2, UBAC), в модуляции риска канцерогенного действия ультрафиолетового излучения. По мнению авторов, значительный интерес представляют данные о роли полиморфизмов гена рецептора витамина D (VDR) как возможных предикторов риска развития немеланомного рака кожи. Рассматриваются дальнейшие перспективы научных исследований по изучению совокупной роли генома и факторов внешней среды в оценке риска немеланомного рака кожи.

Об авторах

Марьянна Борисовна Жилова
Государственный научный центр дерматовенерологии и косметологии
Россия
Доктор медицинских наук, заведующий отделением физиотерапии.

107076, Москва, ул. Короленко, д. 3 стр. 6.

Тел.: +7 (495) 785-20-47.

SPIN-код: 8930-4073



Мария Михайловна Бутарева
Государственный научный центр дерматовенерологии и косметологии
Россия

Доктор медицинских наук, и.о. заведующего клиникой.

107076, Москва, ул. Короленко, д. 3 стр. 6.

Тел.: +7 (495) 785-20-90.

SPIN-код: 8092-5896



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Для цитирования:


Жилова М.Б., Бутарева М.М. УФ-излучение как фактор риска немеланомного рака кожи. Генетические детерминанты онкогенеза. Вестник Российской академии медицинских наук. 2018;73(5):306-313. https://doi.org/10.15690/vramn941

For citation:


Zhilova M.B., Butareva M.M. UV-radiation as a Risk Factor for Non-melanoma Skin Cancer. Genetic Determinants of Carcinogenesis. Annals of the Russian academy of medical sciences. 2018;73(5):306-313. (In Russ.) https://doi.org/10.15690/vramn941

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