Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC94110.15690/vramn941ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИUV-radiation as a Risk Factor for Non-melanoma Skin Cancer. Genetic Determinants of CarcinogenesisУФ-излучение как фактор риска немеланомного рака кожи. Генетические детерминанты онкогенезаhttps://orcid.org/0000-0003-2545-2129ZhilovaMarianna B.ЖиловаМарьянна Борисовна
Russian Federation

MD, PhD.

3 bld. 6 Korolenko street, 107076 Moscow.

Tel.: +7 (495) 785-20-47.

SPIN-код: 8930-4073

Доктор медицинских наук, заведующий отделением физиотерапии.

107076, Москва, ул. Короленко, д. 3 стр. 6.

Тел.: +7 (495) 785-20-47.

SPIN-код: 8930-4073

zhilova2@mail.ruhttps://orcid.org/0000-0003-1521-1989ButarevaMaria M.БутареваМария Михайловна
Russian Federation

MD, PhD.

3 bld. 6 Korolenko street, 107076 Moscow.

SPIN-код: 8092-5896

Доктор медицинских наук, и.о. заведующего клиникой.

107076, Москва, ул. Короленко, д. 3 стр. 6.

Тел.: +7 (495) 785-20-90.

SPIN-код: 8092-5896

butareva@cnikvi.ruState Scientific Center of Dermatovenereology and CosmetologyГосударственный научный центр дерматовенерологии и косметологии201120187353063131801201826092018Copyright ©; 2018, "Paediatrician" Publishers LLCCopyright ©; 2018, Издательство "Педиатръ"2018"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/941

The review presents modern data on the role of ultraviolet (UV) radiation in the pathogenesis of non-melanoma skin cancer (NMSC), the problem of THE risk of developing NMSC, in particular, squamous cell and basal cell skin cancer both in the population and in long-term repeated irradiation of phototherapy (PUVA therapy, UVB therapy, UVB-311 therapy) in patients with psoriasis. The paper considers the mechanisms of UV-induced cell damage by different spectral ranges (UVA, UVB) including the formation of photoproducts, damage to genomic DNA and other cellular structures, violation of the regulation of signaling pathways, the development of chronic inflammation, secondary immunosuppression. The review summarizes the results of large epidemiological studies discussing the role of gene polymorphisms in the homologous DNA repair XRCC3, gene telomerase TERT-CLPTMI, cytokine IL10 gene, MTHFR gene, encoding the folate synthesis, genes involved in pigmentirovanie MC1R, EXOC2, UBAC2 in the modulation of risk of carcinogenic effect of UV radiation. According to the authors’ opinion, the most vital and significant is data on the role of vitamin D receptor (VDR) gene polymorphisms as possible predictors of the risk of NMSC development. The further prospects of academic research on the cumulative role of the genome and environmental factors in the risk assessment of NMSC are revealed.

В обзоре представлены современные данные о роли ультрафиолетового излучения (УФ) в патогенезе немеланомного рака кожи, в частности изучена проблема развития плоскоклеточного и базальноклеточного рака кожи в популяции и при многокурсовом применении методов фототерапии (ПУВА, УФВ, УФВ-311) у больных псориазом. Рассматриваются механизмы УФ-индуцированного повреждения клетки разными спектральными диапазонами (УФА, УФВ), такие как формирование фотопродуктов, повреждение геномной ДНК и других клеточных структур, нарушение регуляции сигнальных путей, развитие хронического воспаления, вторичной иммуносупрессии. Обобщены результаты крупных эпидемиологических исследований, где обсуждается роль полиморфизмов гена гомологичной репарации ДНК XRCC3, гена теломеразы TERT-CLPTMI, гена цитокина IL10, гена MTHFR, кодирующего синтез фолатов, а также генов, участвующих в пигментообразовании (MC1R, EXOC2, UBAC), в модуляции риска канцерогенного действия ультрафиолетового излучения. По мнению авторов, значительный интерес представляют данные о роли полиморфизмов гена рецептора витамина D (VDR) как возможных предикторов риска развития немеланомного рака кожи. Рассматриваются дальнейшие перспективы научных исследований по изучению совокупной роли генома и факторов внешней среды в оценке риска немеланомного рака кожи.

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