The Study of Influence of Different Methods of Local Treatment on Wound Healing in Patients with Diabetic Foot Ulcers


Aim. To evaluate the influence of different methods of local treatment on tissue repair in patients with diabetic foot ulcers.

Materials and methods. We evaluated such clinical characteristics as wound size and local perfusion after using negative pressure wound therapy (NPWT), local collagen, and standard care in patients with diabetic foot ulcers. We observed 63 patients with neuropathic and neuroischemic forms of diabetic foot (without critical ischemia) after surgical debridement. After that 21 patients received NPWT, 21 local collagen treatment and 21 ― standard care.

Results. After using NPWT wound area and depth decreased in 19,8% and 42,8% (p<0.05), in group of collagen dressings in 26,4 and 30,4% (p<0.05). In control group those parameters were 17,0 и 16.6% respectively (p<0.05). There was found the significant increase of local perfusion according to oxygen monitoring in group of NPWT (p<0.05).

Conclusion. The received data showed that the intensity of lower limb tissue repair processes increases more significant after using NPWT and collagen dressings in comparison to standard care which is found according to wound size and tissue perfusion alterations.

About the authors

E. L. Zaitseva

Endocrinology Research Centre

Author for correspondence.
Moscow, Russian Federation Russian Federation

A. Yu. Tokmakova

Endocrinology Research Centre

Moscow, Russian Federation

M. V. Shestakova

Endocrinology Research Centre

ORCID iD: 0000-0002-5057-127X

Moscow, Russian Federation

G. R. Galstyan

Endocrinology Research Centre

ORCID iD: 0000-0001-6581-4521

Moscow, Russian Federation

L. P. Doronina

Endocrinology Research Centre

Moscow, Russian Federation


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