THE COMPARATIVE ANALYSIS OF AMYLOIDOSIS VARIOUS MODELS

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Abstract

Considered natural and experimental amyloidosis models in the existing theories context and known amyloidogenesis mechanisms. Available clinical and experimental observations indicate that the opinion of a fatal incurable amyloidosis wrong. It is shown that there is a significant amount of experimental easily replicable amyloidosis models, which may be used for practicing the treatment methods of this pathology. We offer an amyloidosis models classification: natural (animal models with generic amyloidosis), cell clones, artificial (infectious, protein, etc.). Based on the analysis of amyloidosis existing models concluded — none of the accepted in the scientific the theories community for amyloid building does not combine or explains all known facts about the amyloidogenesismechanisms. It is assumed that there is a proteins group, the beta-sheet structure, which are potentially capable of amyloid conformation building. It is assumed that beta-sheets of these proteins have similar amino acid composition. The condition for the amyloid building conformation is getting too much protein in sufficient quantities in an uncharacteristic place where the ionic strength of the tissue fluid is such that it promotes the amyloid building conformation. It is assumed that an unfortunate amount of ionic strength environment amyloid protein is provided by polysaccharides, tubulins proteins and ionized silicon.

 

About the authors

V. A. Kozlov

I.N. Ul’yanov Chuvash State University, Cheboksary, Russian Federation

Author for correspondence.
Email: pooh12@yandex.ru
доктор биологических наук, кандидат медицинских наук, профессор кафедры фармакологии, клинической фармакологии и биохимии Чувашского государственного университета им. И.Н. Ульянова Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

S. P. Sapozhnikov

I.N. Ul’yanov Chuvash State University, Cheboksary, Russian Federation

Email: pooh12@yandex.ru
доктор медицинских наук, заведующий кафедрой медицинской биологии с курсом микробиологии и вирусологии Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

A. I. Sheptukhina

I.N. Ul’yanov Chuvash State University, Cheboksary, Russian Federation

Email: pooh12@yandex.ru
студентка 5-го курса медицинского факультета Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский проспект, д. 45, тел.: +7 (8352) 45-26-73 Россия

A. V. Golenkov

I.N. Ul’yanov Chuvash State University, Cheboksary, Russian Federation

Email: pooh12@yandex.ru
доктор медицинских наук, профессор, заведующий кафедрой психиатрии, медицинской психологии и неврологии Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

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