СРАВНИТЕЛЬНЫЙ АНАЛИЗ РАЗЛИЧНЫХ МОДЕЛЕЙ АМИЛОИДОЗА

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Аннотация

Рассмотрены естественные и экспериментальные модели амилоидоза в контексте существующих теорий и известных механизмов амилоидогенеза. Имеющиеся клинические и экспериментальные наблюдения свидетельствуют, что мнение о фатальной неизлечимости амилоидоза неверно. Показано, что существует значительное количество экспериментальных достаточно легко воспроизводимых моделей амилоидоза, которые могут быть использованы для отработки методов лечения этой патологии. Предложена классификация моделей амилоидоза: естественные (животные модели с генуинным амилоидозом), клеточные клоны, артифициальные (инфекционные, белковые, прочие). На основании анализа существующих моделей амилоидоза сделан вывод о том, что ни одна из принятых в научном сообществе теорий образования амилоида не объединяет и не объясняет все известные факты о механизмахамилоидогенеза. Предположено, что существует группа белков, структура β-листа которых потенциально способна к образованию амилоиднойконформации, и что β-листы таких белков имеют близкий аминокислотный состав. Условие образования амилоидной конформации — это попадание такого белка в достаточном количестве в несвойственное ему место, где ионная сила тканевой жидкости такова, что способствует образованию амилоидной конформации. По-видимому, неблагоприятная величина ионной силы среды окружения амилоидного белка обусловлена влиянием полисахаридов, тубулиновых белков и ионизированного кремния.

 

Об авторах

В. А. Козлов

Чувашский государственный университет им. И.Н. Ульянова, Чебоксары, Российская Федерация

Автор, ответственный за переписку.
Email: pooh12@yandex.ru
доктор биологических наук, кандидат медицинских наук, профессор кафедры фармакологии, клинической фармакологии и биохимии Чувашского государственного университета им. И.Н. Ульянова Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

С. П. Сапожников

Чувашский государственный университет им. И.Н. Ульянова, Чебоксары, Российская Федерация

Email: pooh12@yandex.ru
доктор медицинских наук, заведующий кафедрой медицинской биологии с курсом микробиологии и вирусологии Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

А. И. Шептухина

Чувашский государственный университет им. И.Н. Ульянова, Чебоксары, Российская Федерация

Email: pooh12@yandex.ru
студентка 5-го курса медицинского факультета Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский проспект, д. 45, тел.: +7 (8352) 45-26-73 Россия

А. В. Голенков

Чувашский государственный университет им. И.Н. Ульянова, Чебоксары, Российская Федерация

Email: pooh12@yandex.ru
доктор медицинских наук, профессор, заведующий кафедрой психиатрии, медицинской психологии и неврологии Чувашского государственного университета им. И.Н. Ульянова
Адрес: 428015, Чебоксары, Московский пр-т, д. 45, тел.: +7 (8352) 45-26-73 Россия

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