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Вестник Российской академии медицинских наук

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МикроРНК как важные диагностичеcкие предвестники развития акушерской патологии

https://doi.org/10.15690/vramn.v70.i4.1416

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Аннотация

МикроРНК (мкНК) — класс коротких нуклеотидных последовательностей (21–27 нуклеотидов) РНК, не участвующих в синтезе белка. мкРНК рассматривают как эффективные посттранскрипционные негативные регуляторы экспрессии генов, связывающи- еся со специфическими участками матричных РНК (мРНК) в цитоплазме, обеспечивающие репрессию трансляции или деградацию транскриптов мишеней мРНК. Показана роль мкРНК в развитии нормальной беременности и ее осложнений, уделено внимание профилям мкРНК на разных сроках физиологической беременности, особенно при иммунологической толерантности организма матери к тканям плода во время беременности. Также отмечены мкРНК, ассоциированные с иммуносупрессией, представлен профиль мкРНК, связанных с преэклампсией. Определение плацентарных мкРНК в материнском кровотоке рекомендовано исполь- зовать в качестве раннего прогностического биомаркера значимой акушерской патологии до наступления клинической манифестации заболевания.

Об авторах

Наталья Викторовна Низяева
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

кандидат медицинских наук, старший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4



Наталья Енкыновна Кан
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

доктор медицинских наук, заведующая акушерским обсервационным отделением,

117997, Москва, ул. Академика Опарина, д. 4



Виктор Леонидович Тютюнник
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

доктор медицинских наук, заведующий акушерским физиологическим отделением,

117997, Москва, ул. Академика Опарина, д. 4



Наталья Анатольевна Ломова
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

кандидат медицинских наук, научный сотрудник акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4



Марина Николаевна Наговицына
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

младший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4



Ксения Николаевна Прозоровская
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

врач акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4



Александр Иванович Щёголев
Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова
Россия

доктор медицинских наук, профессор, заведующий 2-м  патологоанатомическим отделением,

117997, Москва, ул. Академика Опарина, д. 4



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Для цитирования:


Низяева Н.В., Кан Н.Е., Тютюнник В.Л., Ломова Н.А., Наговицына М.Н., Прозоровская К.Н., Щёголев А.И. МикроРНК как важные диагностичеcкие предвестники развития акушерской патологии. Вестник Российской академии медицинских наук. 2015;70(4):484-492. https://doi.org/10.15690/vramn.v70.i4.1416

For citation:


Nizyaeva N.V., Kan N.E., Tyutyunnik V.L., Lomova N.A., Nagovitsyna M.N., Prozorovskaya K.N., Shchyogolev A.I. MicroRNAs As An Important Precursors of Diagnostic Obstetric Pathology. Annals of the Russian academy of medical sciences. 2015;70(4):484-492. (In Russ.) https://doi.org/10.15690/vramn.v70.i4.1416

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