МикроРНК как важные диагностичеcкие предвестники развития акушерской патологии

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МикроРНК (мкНК) — класс коротких нуклеотидных последовательностей (21–27 нуклеотидов) РНК, не участвующих в синтезе белка. мкРНК рассматривают как эффективные посттранскрипционные негативные регуляторы экспрессии генов, связывающи- еся со специфическими участками матричных РНК (мРНК) в цитоплазме, обеспечивающие репрессию трансляции или деградацию транскриптов мишеней мРНК. Показана роль мкРНК в развитии нормальной беременности и ее осложнений, уделено внимание профилям мкРНК на разных сроках физиологической беременности, особенно при иммунологической толерантности организма матери к тканям плода во время беременности. Также отмечены мкРНК, ассоциированные с иммуносупрессией, представлен профиль мкРНК, связанных с преэклампсией. Определение плацентарных мкРНК в материнском кровотоке рекомендовано исполь- зовать в качестве раннего прогностического биомаркера значимой акушерской патологии до наступления клинической манифестации заболевания.

Об авторах

Наталья Викторовна Низяева

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Автор, ответственный за переписку.
Email: Niziaeva@gmail.com

кандидат медицинских наук, старший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Наталья Енкыновна Кан

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: N_kan@oparina4.ru

доктор медицинских наук, заведующая акушерским обсервационным отделением,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Виктор Леонидович Тютюнник

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: V_tioutiounnik@oparina4.ru

доктор медицинских наук, заведующий акушерским физиологическим отделением,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Наталья Анатольевна Ломова

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: Natasha-lomova@yandex.ru

кандидат медицинских наук, научный сотрудник акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Марина Николаевна Наговицына

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: moremore84@mail.ru

младший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Ксения Николаевна Прозоровская

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: ksenyap@inbox.ru

врач акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4

Россия

Александр Иванович Щёголев

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова

Email: Ashegolev@oparina4.ru

доктор медицинских наук, профессор, заведующий 2-м  патологоанатомическим отделением,

117997, Москва, ул. Академика Опарина, д. 4

Россия

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