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Background: The article is devoted to the study of clinical and laboratory characteristics of the current of hemorrhagic vasculitis in children in the Republic of Buryatia. Patients and methods: The study included 27 patients aged 7,6±4,02 years, who conducted clinical and laboratory tests, immunological study of antiphospholipids of antibodies, genetic testing for thrombophilia markers of candidate genes. Results: The results showed that hemorrhagic vasculitis often affects children of Buryat nationality. In 96% of cases there are mixed clinical forms of the disease. 63% of children of hemorrhagic vasculitis preceded by various factors, a higher percentage of infectious diseases. The first clinical symptom in 63% of patients is a typical purpura hemorrhagic rash. Results of clinical laboratory blood tests revealed no significant deviations. Circulation of lupus anticoagulant was detected in 37% of subjects . The аCL IgM detected in 3 children, aβ2-GP-I IgA — in 4 , aβ2-GP-I IgM — in 1 patient. Carriers of thrombophilia polymorphisms were in 95% of children. Noted that homozygous variants of genes polymorphisms of methylenetetrahydrofolateredreductase and plasminogen activator inhibitor-1 correlate with the presence of urinary symptoms and recurrence of the rash. Conclusion: The study shows the risk of recurrent flow of hemorrhagic vasculitis and nefritis of Henoch–Schonlein in children with thrombophilia gene polymorphism.

About the authors

L. V. Zhdanova

Scientific Centre for Problems of Family Health And Human Reproduction, Irkutsk, Russian Federation
Buryat State University, Ulan-Ude, Russian Federation

Author for correspondence.

кандидат медицинских наук, заместитель директора Бурятского филиала НЦ ПЗСиРЧ, старший преподаватель ФГБОУ ВПО «Бурятский государственный университет»
Адрес: 670042, Улан-Удэ, пр-т Строителей, д. 2а, тел: (3012) 45-19-13, (3012) 33-37-73

Russian Federation

L. I. Patrushev

Institute of Bioorganic Chemistry, Moscow, Russian Federation


доктор биологических наук, заведующий лабораторией генома человека ИБХ РАН
Адрес: 117997, Москва, ул. Миклухо-Маклая, д. 16, тел.: (499) 429-86-10

Russian Federation

V. V. Dolgich

Institute of Bioorganic Chemistry, Moscow, Russian Federation


доктор медицинских наук, главный врач Клиники ПЗСиРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: (3952) 20-73-67

Russian Federation

A. B.-G. Bimbaev

Institute of Bioorganic Chemistry, Moscow, Russian Federation


кандидат медицинских наук, директор Бурятского филиала НЦ ПЗСиРЧ
Адрес: 670042, Улан-Удэ, пр-т Строителей, д. 2а, тел.: (3012) 45-19-18

Russian Federation

O. C. Choicova

Institute of Bioorganic Chemistry, Moscow, Russian Federation


кандидат медицинских наук, заведующая лабораторией Бурятского филиала НЦ ПЗСиРЧ Адрес: Улан-Удэ, пр-т Строителей, д. 2а, тел.: (3012) 45-19-13

Russian Federation


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