EFFECT OF IMMUNOTHERAPY ON THE CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER

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Abstract

For the last thirty years immunotherapy has become an integral part of treatment of some cancers. The most effective approach in this context would be the use of complex immunostimulatory factors including tumor antigen in different forms, interleukins that stimulate differentiation. Background: The aim of the study was to compare cellular immune response on specific and combined immunotherapy in patients with cervical cancer. Patients and methods: 76 cervical cancer patients undergoing combined radiotherapy were included into the study. Plus to basic radiation treatment two types of immunotherapy was performed: first — autolymphocytes reinfusion after in vitro incubation with tumor antigen (tumor tissue homogenate) and interleukin-2, second — combination of above mentioned immunotherapy, interleukin-2 and systemic enzyme. Results: This has resulted in increase of cellular immunity parameters in the main group with combined immunotherapy an excess of cells with killer activity to ensure an effective anti-tumor immune response and, accordingly, the clinical efficacy of specific methods and adoptive immunotherapy in patients with cervical cancer. Conclusion: Immunotherapy usage in the form of a preparation of interleukin-2 and a system enzymotherapy in a combination with a specific immunotherapy is possible. This way of treatment is recommended in cases of decreasing of cellular immunity indicators.

About the authors

A. F. Lazarev

Altai Regional Oncological Clinic, Barnaul, Russian Federation

Author for correspondence.
Email: aoc@ab.ru
доктор медицинских наук, профессор, директор Алтайского филиала ГУ «РОНЦ им. Н.Н. Блохина»
Адрес: 656000, Барнаул, ул. Никитина, д. 77, тел.: (385) 263-26-20 Россия

D. K. Kenbayeva

City Oncological Clinic of Astana, Republic of Kazakhstan

Email: dikenb@mail.ru
кандидат медицинских наук, заведующая отделением гинекологии Городского онкологического диспансера г. Астаны
Адрес: 010000, Астана, ул. Манаса, д. 17, тел.: (717) 254-20-30 Казахстан

R. K. Medeubayev

Astana Medical University, Republic of Kazakhstan

Email: rustemed@mail.ru

доктор медицинских наук заведующий курсом онкологии факультета усовершенствования врачей АО «Медицинский университет Астана»
Адрес: 010000, Астана, ул. Бейбитшилик, д. 53, тел.: (717) 253-94-55

Казахстан

A. E. Gorbatenko

Semey State Medical University, Republic of Kazakhstan

Email: aegorbat@mail.ru

ассистент кафедры специальных дисциплин Государственного медицинского университета г. Семей
Адрес: 071400, Семей, ул. Абая Кунанбаева, д. 103, тел.: (717) 256-42-09

Казахстан

S. Z. Tanatarov

Semey State Medical University, Republic of Kazakhstan

Email: sayat68@mail.ru

кандидат медицинских наук, ассистент кафедры специальных дисциплин Государственного медицинского университета г. Семей
Адрес: 071400, Семей, ул. Абая Кунанбаева, д. 103, тел.: (717) 256-42-09

Казахстан

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