ESTROGENS AND BRAIN

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Abstract

Recent data upon molecular mechanisms of pleiotropic action of estrogens in human brain is presented in the article. Given detailed descriptions of properties of classical and membrane bound estradiol receptors, that maintain gene expression regulation, modulation of neurotransmittent systems and signal cascade activation in neuronal cells. Data upon regional distribution of estradiol receptor subtypes in the brain, their participation in main cell population function control (including progenitor cells) is given. Special attention is paid to estrogen participation in neurogenesis, inflammation and apoptosis regulation in central nervous system; in the control of formation and functioning of cerebral vessels.

About the authors

E. N. Kareva

Pirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, Moscow

Author for correspondence.
Email: elenakareva@mail.ru
доктор медицинских наук, профессор кафедры молекулярной фармакологии и радио- биологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117997, Москва, ул. Островитянова, д. 1 Тел.: (916) 579-55-93 Россия

О. M. Oleynikova

Pirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, Moscow

Email: oleynikova@mail.ru
кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии с курсом ФУВ лечебного факультета ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117049, Москва, Ленинский проспект, д. 8, кор. 8 Тел.: (499) 764-50-02 Россия

V. O. Panov

Pirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, Moscow

Email: nabirf@gmail.com
кандидат медицинских наук, главный научный сотрудник НИИ цереброваскулярной пато- логии и инсульта ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34 Россия

N. L. Shimanovskiy

Pirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, Moscow

Email: shiman@rsmu.ru
член-корреспондент РАМН, профессор, заведующий кафедрой молекулярной фармакологии и радиобиологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 119121, ул. Б. Пироговская, д. 9а Тел.: (499) 246-60-05 Россия

V. I. Skvortsova

Pirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, Moscow

Email: nabirf@gmail.com
доктор медицинских наук, профессор, заведующая кафедрой фундаментальной и кли- нической неврологии и нейрохирургии ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34 Россия

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