ЭСТРОГЕНЫ И ГОЛОВНОЙ МОЗГ

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Представлены современные сведения о молекулярных механизмах плейотропного действия эстрогенов в головном мозге. Подробно описаны свойства классических и мембраносвязанных рецепторов эстрадиола, обеспечивающих регуляцию генной экспрессии, модуляцию нейротрансмиттерных систем и активацию сигнальных каскадов в нейрональных клетках. Приведены данные о региональном распределении подтипов рецепторов эстрадиола в головном мозге, их участии в контроле функций основных клеточных популяций, в том числе клеток-предшественников. Особое внимание уделяется участию эстрогенов в регуляции нейрогенеза, воспаления и апоптоза в центральной нервной системе; в контроле формирования и функционирования церебральных сосудов.

Об авторах

Е. Н. Карева

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва

Автор, ответственный за переписку.
Email: elenakareva@mail.ru
доктор медицинских наук, профессор кафедры молекулярной фармакологии и радио- биологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117997, Москва, ул. Островитянова, д. 1 Тел.: (916) 579-55-93 Россия

О. М. Олейникова

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва

Email: oleynikova@mail.ru
кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии с курсом ФУВ лечебного факультета ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117049, Москва, Ленинский проспект, д. 8, кор. 8 Тел.: (499) 764-50-02 Россия

В. О. Панов

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва

Email: nabirf@gmail.com
кандидат медицинских наук, главный научный сотрудник НИИ цереброваскулярной пато- логии и инсульта ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34 Россия

Н. Л. Шимановский

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва

Email: shiman@rsmu.ru
член-корреспондент РАМН, профессор, заведующий кафедрой молекулярной фармакологии и радиобиологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 119121, ул. Б. Пироговская, д. 9а Тел.: (499) 246-60-05 Россия

В. И. Скворцова

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва

Email: nabirf@gmail.com
доктор медицинских наук, профессор, заведующая кафедрой фундаментальной и кли- нической неврологии и нейрохирургии ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34 Россия

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