Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC34510.15690/vramn.v67i2.122ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИESTROGENS AND BRAINЭСТРОГЕНЫ И ГОЛОВНОЙ МОЗГKarevaE. N.КареваЕ. Н.
Russian Federation

доктор медицинских наук, профессор кафедры молекулярной фармакологии и радио- биологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117997, Москва, ул. Островитянова, д. 1 Тел.: (916) 579-55-93

elenakareva@mail.ruOleynikovaО. M.ОлейниковаО. М.
Russian Federation

кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии с курсом ФУВ лечебного факультета ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117049, Москва, Ленинский проспект, д. 8, кор. 8 Тел.: (499) 764-50-02

oleynikova@mail.ruPanovV. O.ПановВ. О.
Russian Federation

кандидат медицинских наук, главный научный сотрудник НИИ цереброваскулярной пато- логии и инсульта ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34

nabirf@gmail.comShimanovskiyN. L.ШимановскийН. Л.
Russian Federation

член-корреспондент РАМН, профессор, заведующий кафедрой молекулярной фармакологии и радиобиологии имени академика П.В. Сергеева ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 119121, ул. Б. Пироговская, д. 9а Тел.: (499) 246-60-05

shiman@rsmu.ruSkvortsovaV. I.СкворцоваВ. И.
Russian Federation

доктор медицинских наук, профессор, заведующая кафедрой фундаментальной и кли- нической неврологии и нейрохирургии ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразвития России Адрес: 117415, Москва, ул. Лобачевского, д. 42, кор. 6 Тел.: (495) 432-97-34

nabirf@gmail.comPirogov Russian National scientific medical university Ministry of Healthcare and Social Development of Russia, MoscowГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва22022012672Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук485907082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/345

Recent data upon molecular mechanisms of pleiotropic action of estrogens in human brain is presented in the article. Given detailed descriptions of properties of classical and membrane bound estradiol receptors, that maintain gene expression regulation, modulation of neurotransmittent systems and signal cascade activation in neuronal cells. Data upon regional distribution of estradiol receptor subtypes in the brain, their participation in main cell population function control (including progenitor cells) is given. Special attention is paid to estrogen participation in neurogenesis, inflammation and apoptosis regulation in central nervous system; in the control of formation and functioning of cerebral vessels.

Представлены современные сведения о молекулярных механизмах плейотропного действия эстрогенов в головном мозге. Подробно описаны свойства классических и мембраносвязанных рецепторов эстрадиола, обеспечивающих регуляцию генной экспрессии, модуляцию нейротрансмиттерных систем и активацию сигнальных каскадов в нейрональных клетках. Приведены данные о региональном распределении подтипов рецепторов эстрадиола в головном мозге, их участии в контроле функций основных клеточных популяций, в том числе клеток-предшественников. Особое внимание уделяется участию эстрогенов в регуляции нейрогенеза, воспаления и апоптоза в центральной нервной системе; в контроле формирования и функционирования церебральных сосудов.

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