THE ROLE OF REGULATORY T CELLS IN THE DEVELOPMENT OF AUTOIMMUNE PROCESS IN MULTIPLE SCLEROSIS

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  • Authors: Eliseeva D.D.1, Zavalishin I.A.1, Karaulov A.V.2, Bykovskaya S.N.3
  • Affiliations:
    1. Research Center of Neurology RAMS, 6 neurological department
    2. Russian State Medical University, Front cell technologies and regenerative medicine
    3. First Moscow State Medical University I.M. Sechenov, Department of Clinical Immunology and Allergy Summary
  • Issue: Vol 67, No 3 (2012)
  • Pages: 68-74
  • Section: SHORT MESSAGES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/335
  • DOI: https://doi.org/10.15690/vramn.v67i3.188
  • Cite item

Abstract


In the maintenance of immunological tolerance important role belongs to the recently discovered population of regulatory T-cells CD4 + CD25 + FoxP3 +. These cells have potential in suppressing pathologic immune responses observed at various autoimmune diseases including multiple sclerosis. We have shown a reduction in the number and functional activity of T-reg in peripheral blood of patients with multiple sclerosis in the acute stage, the increase in their number during remission, duration of the relationship of the autoimmune process and the degree of disability of patients with the contents of T-reg. The possibility of using the grown ex vivo T-reg for the correction of immunopathological process in multiple sclerosis.

 


About the authors

D. D. Eliseeva

Research Center of Neurology RAMS, 6 neurological department

Author for correspondence.
Email: ddeliseeva@gmail.com

Russian Federation кандидат медицинских наук, младший научный сотрудник лаборатории клинических исследований, врач-невролог 6-го неврологического отделения ФГБУ «НЦН» РАМН Адрес: 125367, Москва, Волоколамское шоссе, д. 80 Тел.: (495) 490-24-13, факс: (495) 490-28-73

I. A. Zavalishin

Research Center of Neurology RAMS, 6 neurological department

Email: 6otdelen@gmail.com

Russian Federation доктор медицинских наук, профессор, руководитель 6-го неврологического отделения ФГБУ «НЦН» РАМН Адрес: 125367, Москва, Волоколамское шоссе, д. 80 Тел.: (495) 490-21-55, факс: (495) 490-28-73

A. V. Karaulov

Russian State Medical University, Front cell technologies and regenerative medicine

Email: drkaraulov@mail.ru

Russian Federation доктор медицинских наук, чл.-корр. РАМН, заведующий кафедрой клинической иммунологии и аллергологии факультета послевузовского профессионального образования ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Адрес: 119435, Москва, ул. Б. Пироговская д. 2, к. 6 Тел.: (495) 395-64-97

S. N. Bykovskaya

First Moscow State Medical University I.M. Sechenov, Department of Clinical Immunology and Allergy Summary

Email: sbykovskaia@gmail.com

Russian Federation доктор медицинских наук, профессор, заведующая Отделом клеточных технологий и регенеративной медицины Российского национального исследовательского медицинского университета (РНИМУ) им. Н.И. Пирогова Адрес: 117997, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-14-44

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