РОЛЬ РЕГУЛЯТОРНЫХ Т-КЛЕТОК В РАЗВИТИИ АУТОИММУННЫХ НАРУШЕНИЙ ПРИ РАССЕЯННОМ СКЛЕРОЗЕ

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Аннотация

В процессах поддержания иммунологической толерантности важная роль принадлежит недавно открытой популяции регуляторных Т-клеток CD4+CD25+FoxP3+ (Т-reg).  Эти клетки обладают огромным потенциалом в подавлении патологического иммунного ответа, наблюдающегося при различных аутоиммунных заболеваниях, в том числе при рассеянном склерозе. Продемонстрировано  снижение числа и функциональной активности Т-reg в периферической крови  больных рассеянным склерозом в стадии обострения, увеличение их количества при ремиссии заболевания, связь длительности аутоиммунного процесса и степени инвалидизации больных с количеством  Т-reg.  Показана возможность использования выращенных ex vivo Т-reg для коррекции иммунопатологических нарушений при рассеянном склерозе.

Об авторах

Д. Д. Елисеева

ФГБУ «Научно-исследовательский институт неврологии» РАМН, Москва

Автор, ответственный за переписку.
Email: ddeliseeva@gmail.com
кандидат медицинских наук, младший научный сотрудник лаборатории клинических исследований, врач-невролог 6-го неврологического отделения ФГБУ «НЦН» РАМН Адрес: 125367, Москва, Волоколамское шоссе, д. 80 Тел.: (495) 490-24-13, факс: (495) 490-28-73 Россия

И. А. Завалишин

ФГБУ «Научно-исследовательский институт неврологии» РАМН, Москва

Email: 6otdelen@gmail.com
доктор медицинских наук, профессор, руководитель 6-го неврологического отделения ФГБУ «НЦН» РАМН Адрес: 125367, Москва, Волоколамское шоссе, д. 80 Тел.: (495) 490-21-55, факс: (495) 490-28-73 Россия

А. В. Караулов

ГБОУ ВПО Первый Московский государственный медицинский университет имени И.М. Сеченова, Москва

Email: drkaraulov@mail.ru
доктор медицинских наук, чл.-корр. РАМН, заведующий кафедрой клинической иммунологии и аллергологии факультета послевузовского профессионального образования ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Адрес: 119435, Москва, ул. Б. Пироговская д. 2, к. 6 Тел.: (495) 395-64-97 Россия

С. Н. Быковская

ГБОУ Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, Москва

Email: sbykovskaia@gmail.com
доктор медицинских наук, профессор, заведующая Отделом клеточных технологий и регенеративной медицины Российского национального исследовательского медицинского университета (РНИМУ) им. Н.И. Пирогова Адрес: 117997, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-14-44 Россия

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