REGIONAL PECULIARITIES IN SEMEN QUALITY AND SERUM HORMONAL CONCENTRATIONS OF CITIZENS FROM EASTERN SIBERIA
- Authors: Osadchuk L.V.1, Kleshchev M.A.1, Gutorova N.V.1, Petrova P.G.2, Troev I.P.2, Ostobunaev V.V.2, Osadchuk A.V.1
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Affiliations:
- Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
- The Medical Institute of the North-East State University, Yakutsk
- Issue: Vol 67, No 3 (2012)
- Pages: 50-55
- Section: ENDOCRINOLOGY: CURRENT ISSUES
- Published: 23.03.2012
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/332
- DOI: https://doi.org/10.15690/vramn.v67i3.185
- ID: 332
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Abstract
The objective of the present study was to evaluate sperm quality and reproductive hormonal level in an unselected population of men who were permanent residents of the Yakutsk city and compare the semen and hormonal parameters with the World Health Organization (WHO, 2001) recommended normal values and the results from other countries. A total of 145 men (mean age 24,1 years) agreed to be included in the study. All the volunteers completed a questionnaire, received a general and reproductive health examination by an andrologist, gave semen and blood samples. We found that the means were 34,69 × 106 spermatozoa/mL for sperm concentration and 39,6% for total motile spermatozoa. Among all volunteers studied 4,3% had azoospermia, 27,0% reported oligozoospermia, 68,1% ― asthenozoospermia. There are no differences between Yakut and Slavs in anthropometric, hormonal or sperm measures, but height and ejaculate volume were higher in Slavs than Yakut men. The data obtained indicated high frequency of suboptimal quality of sperm in males of both nations from this Siberian region in comparison with other Russian regions or European countries.
About the authors
L. V. Osadchuk
Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Author for correspondence.
Email: osadchuk@bionet.nsc.ru
доктор биологических наук, доцент, ведущий научный сотрудник лаборатории эндокринологической генетики Института цитологии и генетики Сибирского отделения РАН Адрес: 630090, Новосибирск, пр. Ак. Лаврентьева, д. 10 Тел.: (383) 330-63-80, моб. (923) 193-22-46; факс: (383) 330-12-78 Россия
M. A. Kleshchev
Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: max82cll@bionet.nsc.ru
младший научный сотрудник лаборатории эндокринологической генетики Института цитологии и генетики Сибирского отделения РАН Тел.: (913) 480-09-17 Е-mail: max82cll@bionet.nsc.ru Россия
N. V. Gutorova
Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: kras_nv@bionet.nsc.ru
инженер-исследователь лаборатории эндокринологической генетики Института цитологии и генетики Сибирского отделения РАН Тел.: (913) 929-44-60 Россия
P. G. Petrova
The Medical Institute of the North-East State University, Yakutsk
Email: mira_44@mail.ru
доктор медицинских наук, профессор, ректор кафедры нормальной и патологиче- ской физиологии Медицинского института Северо-Восточного федерального университета им. М.К. Аммосова Адрес: 677000, Якутск, ул. Кулаковского, д. 36 Тел./факс: (4112) 36-30-46 Россия
I. P. Troev
The Medical Institute of the North-East State University, Yakutsk
Email: ysumed@yandex.ru
аспирант очной формы 1 года обучения кафедры нормальной и патологической физиологии Медицинского института Северо-Восточного федерального университета им. М.К. Аммосова Тел.: (914) 105-05-47 Россия
V. V. Ostobunaev
The Medical Institute of the North-East State University, Yakutsk
Email: vasilii.ostobunaev@mail.ru
аспирант заочной формы 1 года обучения, врач уролог-андролог кафедры общей хирургии, травматологии, ортопедии и медицины катастроф Медицинского института Северо-Восточного феде- рального университета им. М.К. Аммосова Тел.: (924) 173-00-24 Россия
A. V. Osadchuk
Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: osadchuk@bionet.nsc.ru
кандидат биологических наук, доцент, заведующий лабораторией эндокринологи- ческой генетики Института цитологии и генетики Сибирского отделения РАН Тел.: (923) 221-67-15 Россия
References
- Joffe M. What has happened to human fertility? Hum. Reprod. 2010; 25: 295–307.
- Auger J., Jouannet P. Evidence for regional differences of semen quality among fertile French men. Hum. Reprod. 1997; 12: 740–745.
- Gao J., Gao E., Yang Q. et al. Semen quality in a residential, geographic and age representative sample of healthy Chinese men. Hum. Reprod. 2007; 22: 477–484.
- Jorgensen N., Andersen A.G., Eustache F. et al. Regional differences in semen quality in Europe. Hum. Reprod. 2001; 16: 1012– 1019.
- Swan S.H., Brazil C., Drobnis E.Z. et al. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect. 2003; 111: 414–420.
- Jоrgensen N., Asklund C., Carlsen E., Skakkebаk N.E. Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. Int. J. Androl. 2006; 29: 54–61.
- Iwamoto T., Nozawa S., Yoshiike M. et al. Semen quality of 324 fertile Japanese men. Hum. Reprod. 2006; 21: 760–765.
- Rukovodstvo VOZ po laboratornomu issledovaniiu e`iaquliata cheloveka i vzaimodei`stviia spermatozoidov s tcervikal`noi` sliz`iu. M.: MedPress. 2001. 143 c.
- Chia S.-E., Tay S.K., Lim S.T. What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. Hum. Reprod. 1998; 13: 3394–3398.
- Osadchuk L.V., Cleshchev M.A., Temniqov N.D. i dr. Vy`soqaia chastota suboptimal`nogo kachestva spermy` u zhitelei` Sibirskogo regiona (na primere g. Novosibirska). Andrologiia i genital`naia hirurgiia. 2010; 3: 52–55.
- Gutorova N.V., Osadchuk L.V., Cleshchev M.A. i dr. Kachestvo spermy` i urovni reproduqtivny`kh gormonov u muzhchin Kemerowskoi` populiatcii. Problemy` reproduqtcii. 2010; 6: 86–90.
- Cleshchev M.A., Osadchuk A.V., Gutorova N.V. i dr. Analiz spermatogennoi` funktcii u muzhskogo naseleniia g. Arhangel`ska. Andrologiia i genital`naia hirurgiia. 2011; 2: 56–60.
- Petersen C., Soder O. The Sertoli cell — a hormonal target and ‘super’ nurse for germ cells that determines testicular size. Horm. Res. 2006; 66: 153–161.
- Plant T.M., Marshall G.R. The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocr Rev. 2001; 22: 764–786.
- Andrologiia: muzhskoe zdorov`e i disfunqtciia reproduktivnoi` sistemy` / pod red. E`. Nishlaga, G.M. Bere. M.: MIA. 2005. 554.