EVOLUTION AND REVOLUTIONARY EVENTS IN ONCOLOGY IN THE END OF XX - BEGINNING OF XXI CENTURY

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Abstract


This review highlights major achievements of the Russian oncology in the past decades, such as works of N.N. Petrov, L.A. Zilber, N.N. Blokhin, E.E. Pogosyants. Revolutionary shift in the understanding of the malignization process have become possible after decoding of human genome, as well as genome of several tumors such as breast cancer, acute myeloblastic leukemia, several brain tumors, testicular cancer and other neoplasms. The issue of stem cells being possible ancestors of tumor cells is also discussed in the review. Also the author observes main modern therapeutic approaches towards cancer treatment. It is specially highlighted that XXI century molecular biology achievements made it possible to start personal tumor treatment based on its specific genotype.



About the authors

A. M. Garin

ФГБУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Author for correspondence.
Email: ronc@list.ru

Russian Federation доктор медицинских наук, профессор, главный научный сотрудник отделения клиниче- ской фармакологии и химиотерапии ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН Адрес: 115478, Москва, Каширское шоссе, д. 24 Тел.: (499) 324-98-74

References

  1. Ajithkumar T.V., Hatcher H.M. Specialist training in oncology. Mosby Elsevier, Edinburgh, 2011.
  2. IARC monographs on evaluation of the carcinogenic risk of chemicals to humans. Lion, IARC. 1979–2002.
  3. Danaei G., van der Hoom S., Lopez A.D. et al. Causes of cancer in the world: comparative assesment of the behavior and environmental risk factors. Lancet. 2005; 366: 1784−1793.
  4. Peto J. Cancer epidemiology in the last century and next decade. Nature. 2001; 411: 390–395.
  5. Zaridze D.G. Profilaktika raka: rukovodstvo dlya vrachei [Cancer Prevention: a Guide for Physicians]. Moscow, IMA-press, 2009. 50 p.
  6. Vogelstein B., Fearon E.R., Hamilton S.R. et al. Genetic alterations during colorectal tumor development. N. Engl. J. Med. 1988; 319 (9): 525–532.
  7. Siegel R., Waud E., Brawley O., Jemal A. Cancer statistics-2011. CA Cancer J Clin. 2011; 61: 212– 236.
  8. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 2000; 100 (1): 57−70.
  9. Futreal P.A. A sensus of human cancer genes. Nat. Rev. Canc. 2004; 4: 177–183.
  10. Baselga J., Arribal J. Treating cancers kinase addiction. Nat. Med. 2004; 10: 786−787.
  11. Weinberg R.A. The biology of cancer. New York: Garland Science. 2007. 796 p.
  12. Jordan C.T. Cancer stem cells biology: from leukemia to tumors. Curr. Opin. Cell Biol. 2004; 16: 708−713.
  13. Wheler J., Kurzrock R. New model of carcinogenesis: cancer stem cell hypothesis. In: Targeted cancer therapy. Eds. R. Kurzrock. Humana Press. 2010. Р. 13–15.
  14. Pecorino L. Molecular biology of cancer. Oxford University Press. 2006.
  15. Jabbour E., Cortes J., Kantarjian H. Targeted therapy in chronic myeloid leukemia. In: Targeted cancer therapy. Eds. R. Kurzrock, A. Markman. Humana Press. 2011. Р. 87–99.
  16. Cancer progress net. An interactive history of cancer research advances. American Society of Clinical Oncology. 2011.
  17. Perevodchikova N.I. Rukovodstvo po khimioterapii opukholevykh zabolevanii [Guide in Chemotherapy of Neoplastic Diseases]. Moscow, Prakticheskaya meditsina, 2011.
  18. Garin A.M., Bazin I.S. Spravochnoe rukovodstvo po lekarstvennoi terapii solidnykh opukholei [Reference Manual for Drug Therapy of Solid Tumors]. Moscow, Izdatel'stvo Moskovskogo Universiteta, 2010.
  19. Wahby S.M., Hughes T.E. Anticancer agents. In: The bethesda handbook of clinical oncology / eds. J. Abraham, J.L. Gulley, C.J. Allegra. Wolters Kluwer. 2010. p. 559−643.
  20. Cassidi J., Bissett D., Spence R.A.J., Payne M. Oxford handbook of oncology. Oxford University Press, 2010.
  21. Coyle V.M., Allen V.L., Jilthesh P.V., Johnston P.G. Basic genomics for practicing oncologists. In: The bethesda handbook of clinical oncology / eds. J. Abraham, J.L. Gulley, C.J. Allegra. Wolters Kluwer. 2010. p. 548.

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