THE DISTRIBUTION OF IODINE-125 LABELED ALPHA-FETOPROTEIN IN THE ANIMAL ORGANISM AND ITS ACCUMULATION IN THE TUMOR

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  • Authors: Severin S.E.1, Moskaleva E.Y.1, Kulakov V.N.2, Severin E.S.3, Slobodyanik I.I.2, Klimova T.P.2
  • Affiliations:
    1. State Health Institution the Moscow Research Institute of Medical Ecology
    2. Russian Research Center of Molecular Diagnostics and Treatment
    3. Federal Medical Biophysical A.I. Burnasyan’s Centre of Federal Biomedical Agency of the Russian Federation
  • Issue: Vol 67, No 4 (2012)
  • Pages: 11-15
  • Section: BIOCHEMISTRY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/314
  • DOI: https://doi.org/10.15690/vramn.v67i4.193
  • Cite item

Abstract


The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of alpha-fetoprotein in different tissues and organs of animals was observed mainly 5 hours after injection. Then the protein was gradually eliminated from the body. In the liver, intestine and blood of intact animals 125I-alpha-fetoprotein persists for at least three days. Accumulation of alpha-fetoprotein in various tissues and organs may determine the different biological effects of this protein. In the mice with transplanted lymphatic leukemia cells P388 the high level of alpha-fetoprotein accumulation was detected in the tumor tissue, reaching 6% of the injected amount per 1 g of tissue. This allows considering the radionuclide-labeled alpha-fetoprotein as a promising medical radionuclide marker for the radiological detection of malignant tumors.

 


S. E. Severin

State Health Institution the Moscow Research Institute of Medical Ecology

Author for correspondence.
Email: sergsev@inbox.ru

Russian Federation доктор химических наук, профессор, член-корр. РАМН, генеральный директор ГУЗ Московский НИИ медицинской экологии Адрес: 117149, Москва, Симферопольский бульвар, д. 8 Тел.: (499) 613-23-20

E. Yu. Moskaleva

State Health Institution the Moscow Research Institute of Medical Ecology

Email: moskalevaey@mail.ru

Russian Federation доктор биологиче-ских наук, профессор, заведующая лабораторией клеточной биохимии ГУЗ Московский НИИ меди-цинской экологии Департамента здравоохранения г. Москвы Адрес: 117149, Москва, Симферопольский бульвар, д. 8 Тел.: 8-916-522-40-54

V. N. Kulakov

Russian Research Center of Molecular Diagnostics and Treatment

Email: vikov@rambler.ru

Russian Federation доктор химических наук, профессор, ведущий научный сотрудник отдела радиационных технологий Федеральный медицин-ский биофизический центр им. А.И. Бурназяна Федерального медико-биологического агентства Российской Федерации Адрес: 123182, Москва, ул. Живописная, д. 46 Тел.: 8(499) 193-01-86; факс: 8(499) 193-45-73

E. S. Severin

Federal Medical Biophysical A.I. Burnasyan’s Centre of Federal Biomedical Agency of the Russian Federation

Email: e.severin@mail.ru

Russian Federation доктор химических наук, профессор, член-корр. РАН, генеральный директор ОАО «Всероссийский научный центр молекулярной диагностики и лечения» Адрес: 117149, Москва, Симферопольский бульвар, д. 8 Тел.: (499) 613-23-51

I. I. Slobodyanik

Russian Research Center of Molecular Diagnostics and Treatment

Email: vikov@rambler.ru

Russian Federation старший инженер отдела радиационных технологий Федерального медицин-ского биофизического центра им. А.И. Бурназяна Федерального медико-биологического агентства Российской Федерации Адрес: 123182, Москва, ул. Живописная, д. 46 Тел.: 8(499) 193-01-86; факс: 8(499) 193-45-73

T. P. Klimova

Russian Research Center of Molecular Diagnostics and Treatment

Email: tab@ineos.ac.ru

Russian Federation кандидат физико-математических наук, научный сотрудник Института элементоорганических соединений им. А.Н. Несмеянова РАН Адрес: 119991, Москва, ул. Вавилова, д. 28 Тел.: 8(499) 135-92-69

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