VENTRICULAR ARRHYTHMIAS AND ARTERIAL HYPERTENSION: ROLE OF INFLAMMATORY BIOMARKERS IN ARRHYTHMIA DEVELOPMENT

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Abstract


Arrhythmogenic role of proinflammatory cytokines is still unclear despite of wide discussion on inflammatory arrhythmogenic mechanisms. The main goal of study was to compare levels of tumor necrosis factor a, interleukin 6 and interleukin 4 in hypertensive patients with and without ventricular rhythm disturbances. The study included 100 cases, 50 of those had ventricular arrhythmias. Levels of tumor necrosis factor a, interleukin 6 and interleukin 4 were studied. Possible connections of above mentioned biomarkers with ventricular arrhythmias, blood pressure, echocardiography left ventricle data were evaluated. Higher level of biomarkers was associated with presence of ventricular arrhythmias; higher rate of ventricular extrasystoles was accompanied with insignificantly lower biomarker level.

 


About the authors

L. M. Vasilets

Perm State Medical Academy

Author for correspondence.
Email: lena.ratanova@mail.ru

Russian Federation доктор медицинских наук, профессор кафедры госпитальной терапии № 1 Пермской государственной медицинской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

A. V. Tuev

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation доктор медицинских наук, профессор, заведующий кафедрой госпитальной терапии № 1 Пермской государственной медицинской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

E. V. Arshin

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation доктор медицинских наук, профессор кафедры госпитальной терапии № 1 Пермской государственной медицинской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

A. V. Agafonov

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation доктор медицинских наук, профессор кафедры госпитальной терапии № 1 Пермской государственной медицинской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

E. A. Ratanova

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation аспирант кафедры госпитальной терапии № 1 Пермской государственной медицин- ской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

A. A. Krivaya

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation ординатор кафедры госпитальной терапии № 1 Пермской государственной медицинской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

K. V. Trenogina

Perm State Medical Academy

Email: lena.ratanova@mail.ru

Russian Federation ординатор кафедры госпитальной терапии № 1 Пермской государственной медицин- ской академии им. акад. Е.А. Вагнера Адрес: 614990, Пермь, ул. Петропавловская, д. 26

N. E. Grigoriadi

Perm Clinical Regional Hospital

Email: lena.ratanova@mail.ru

Russian Federation кандидат медицинских наук, врач кардиологического отделения Пермской краевой клинической больницы Адрес: 614990, Пермь, ул. Пушкина, д. 85 Тел. (342) 239-32-75

References

  1. Ardashev A.V., Sklyarova T.F., Zhelyakov E. G., Derlyatka A.T., Lemesheva O.B., Ardashev V.N. Nonischemic ventricular arrhythmias: classification, clinical manifestations, diagnosis, and treatment. Cardiology = Kardiologiya. 2007; 11: 62–72.
  2. Golitsin S.P. Benefits and risks of treatment of ventricular arrhythmias. Journal of arrhythmology = Vestnik aritmologii. 2008; 21: 30–42.
  3. Myasnikov G.V. Neurohormones and proinflammatory cytokines in patients with initial chronic heart failure as a result of arterial hypertension depending on presence of insulin resistance syndrome. Ukr. Med. Chasopis = Ukrainian Medical Journal. 2008; 1: 38–42.
  4. Vasilets L.M., Karpunina N.S., Tuev A.V., Sarapulova O.N., Vustina V.V. Cytokine status of patients with arterial hypertension and sinus node dysfunction. Meditsinskii al'manakh = Medical almanac. 2011; 3 (16): 70–72.
  5. Streitner F., Kuschyk J., Veltmann C., Brueckmann M, Streitner I, Brade J, Neumaier M, Bertsch T, Schumacher B, Borggrefe M, Wolpert C. Prospective study of interleukin-6 and the risk of malignant ventricular tachyarrhythmia in ICD-recipients. A pilot study. Cytokine. 2007; 40 (1): 30–34.
  6. Danesh J., Whincup P., Walker M., Lennon L, Thomson A, Appleby P., J Ruth Gallimore, Mark B Pepys.Low grade inflammation and coronary heart disease: prospective study and updated meta analysis. BMJ. 2000; 321: 199–204.
  7. Frustaci A., Russo M.A., Chimenti C. Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study. Eur. Heart J. 2009; 30 (16): 1995–2002.
  8. Kashtal'yan O.A., Pristorom M.S. Comprehensive study of cytokines and heart rate variability in pregnant. Tsitokiny i vospalenie = Cytokines and Inflammation. 2011; 1 (10): 41–45.
  9. Voloshina I.N. The relationship of the proinflammatory activation with severity of arterial hypertension and the possibility of drug correction. Zaporozhskii meditsinskii zhurnal = Zaporozhye Medical Journal. 2010; 12 (5): 18–22.
  10. Mahmud A., Feely J. Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension. 2005; 46: 1118–1122.
  11. Chrysohoou C., Pitsavos C., Panagiotakos D. B., Skoumas J, Stefanadis C. Association between prehypertension status and inflammatory markers related to atherosclerotic disease: the ATTICA study. Am. J. Hypertens. 2004; 17: 568–573.
  12. Rebrova O.Yu. Statisticheskii analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA [Statistical analysis of medical data. Application software package STATISTICA]. Moscow: Mediasfera. 2002. 312 p.
  13. Kopitsa N.P. Prognostic significance of corrected QT interval and brain natriuretic peptide in heart failure following myocardial infarction. Mezhdunarodnyi meditsinskii zhurnal = International Medical Journal. 2004; 10 (2): 22–25.
  14. Henningsen K.M., Nilsson B., Bruunsgaard H. et al. Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation. Scand. Cardiovasc. J. 2009; 43 (5): 285–291.

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