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Вестник Российской академии медицинских наук

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КИНУРЕНИНЫ В ПАТОГЕНЕЗЕ ЭНДОГЕННЫХ ПСИХИЧЕСКИХ ЗАБОЛЕВАНИЙ

https://doi.org/10.15690/vramn.v68i1.535

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Аннотация

Незаменимая аминокислота триптофан метаболизируется по метоксииндольному пути до серотонина, мелатонина и 5-гидроксииндолуксусной кислоты и по кинурениновому пути с образованием кинуренина и его нейроактивных метаболитов, таких как 3-гидроксикинуренин, кинуреновая, хинолиновая и ксантуреновая кислота. Кинуренин и его метаболиты играют важную роль в патогенезе депрессивных расстройств и шизофрении. В обзоре приведены литературные данные по современному состоянию этой проблемы.

 

Об авторах

Ю. Е. Шилов
Научный центр психического здоровья РАМН, Москва, Российская Федерация
Россия


М. В. Безруков
Научный центр психического здоровья РАМН, Москва, Российская Федерация
Россия


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Для цитирования:


Шилов Ю.Е., Безруков М.В. КИНУРЕНИНЫ В ПАТОГЕНЕЗЕ ЭНДОГЕННЫХ ПСИХИЧЕСКИХ ЗАБОЛЕВАНИЙ. Вестник Российской академии медицинских наук. 2013;68(1):35-41. https://doi.org/10.15690/vramn.v68i1.535

For citation:


Shilov Y.E., Bezrukov M.V. KYNURENINES IN PATHOGENESIS OF ENDOGENOUS PSYCHIATRIC DISORDERS. Annals of the Russian academy of medical sciences. 2013;68(1):35-41. (In Russ.) https://doi.org/10.15690/vramn.v68i1.535

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