Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC22210.15690/vramn.v68i1.535PSYCHOLOGY AND PSYCHIATRY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПСИХОЛОГИИ И ПСИХИАТРИИKYNURENINES IN PATHOGENESIS OF ENDOGENOUS PSYCHIATRIC DISORDERSКИНУРЕНИНЫ В ПАТОГЕНЕЗЕ ЭНДОГЕННЫХ ПСИХИЧЕСКИХ ЗАБОЛЕВАНИЙShilovYu. E.ШиловЮ. Е.
Russian Federation

Postgraduate Laboratory of Molecular Biochemistry «the Mental Health Research Center of the Russian Academy of Medical Science» Address: 115522, Moscow, Kashirskoye Highway 34; tel.: (495) 952-91-41

shilov.biochem@gmail.ruBezrukovM. V.БезруковМ. В.
Russian Federation

PhD, Senior Research Worker of Laboratory of Clinical Biochemistry «the Mental Health Research Center of the Russian Academy of Medical Science» Address: 115522, Moscow, Kashirskoye Highway 34; tel.: (495) 952-91-41

bezrmv1chem@mail.ruMental health research center of RAMS, Moscow, Russian FederationНаучный центр психического здоровья РАМН, Москва, Российская Федерация22012013681Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук354107082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/222

The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic acid, quinolinic acid and xanthurenic acid. Kynurenine and related metabolites play a significant role in the pathogenesis of major depressive disorder and schizophrenia. This paper is the review of literature data on the most modern state of this problem.

Незаменимая аминокислота триптофан метаболизируется по метоксииндольному пути до серотонина, мелатонина и 5-гидроксииндолуксусной кислоты и по кинурениновому пути с образованием кинуренина и его нейроактивных метаболитов, таких как 3-гидроксикинуренин, кинуреновая, хинолиновая и ксантуреновая кислота. Кинуренин и его метаболиты играют важную роль в патогенезе депрессивных расстройств и шизофрении. В обзоре приведены литературные данные по современному состоянию этой проблемы.

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