CARCINOGENICITY OF ACRYLONITRILE AND EVALUATION OF APPROACHES TO PATHOGENETIC CORRECTION OF ACRYLATE TOXICITY AND ANTITUMOROGENIC ANTRACYCLINE DOXORUBICI TOXICITY DURING CHEMOTHERAPY

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Abstract


Statistical analysis within the 20-year period showed that approximately 49% of workers who were exposed to widespread industrial poison acrylonitrile subsequently died from malignancy of different localization. The conducted experimental investigations demonstrated that acrylonitrile with the subacute intoxication of animals, the anti-tumor antibiotic doxorubicin, their combination, interwoven tumor and tumor developed against the background the introduction of acrylate and subsequent treatment doxorubicin led to onset of free-radical reactions. These reactions by themselves might stimulate development of malignancy. This fact confirms the need for antioxidant tracking of chemotherapy of tumors in the similar clinical cases.

 


M. M. Tarskikh

Scientific Center of the Health Family Problems and Reproduction of Man, Irkutsk, the Russian Federation

Author for correspondence.
Email: mtarskih@mail.ru

Russian Federation

PhD, Associate Professor, Department of Physiology and Training Method of Biology, Krasnoyarsk State Pedagogical University named after V.P. Astaf’ev Address: 660049, Krasnoyarsk, Ady Lebedevoj St., 89; tel.: (391) 217-17-23

M. A. Shumbasov

Scientific Center of the Health Family Problems and Reproduction of Man, Irkutsk, the Russian Federation

Email: shumbasov.max@rambler.ru

Russian Federation Oncologist, Head of the Day Hospital, Krasnoyarsk regional oncologic dispensary named after A.I. Kryzhanowski Address: 660333, Krasnoyarsk, Pervaya Smolenskaya St., 16; tel.: (391) 264-68-21, (391) 299-20-06

S. I. Kolesnikov

Scientific Center of the Health Family Problems and Reproduction of Man, Irkutsk, the Russian Federation

Email: sikolesnikov2012@gmail.com

Russian Federation RAMS academician, Advisor of Presidium RAMS Honored Worker of Science of Russian Federation

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