Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC21710.15690/vramn.v68i2.551SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯCARCINOGENICITY OF ACRYLONITRILE AND EVALUATION OF APPROACHES TO PATHOGENETIC CORRECTION OF ACRYLATE TOXICITY AND ANTITUMOROGENIC ANTRACYCLINE DOXORUBICI TOXICITY DURING CHEMOTHERAPYКАНЦЕРОГЕННОСТЬ АКРИЛОНИТРИЛА И ОЦЕНКА ВОЗМОЖНОСТЕЙ ПАТОГЕНЕТИЧЕСКОЙ КОРРЕКЦИИ ТОКСИЧНОСТИ АКРИЛАТА И ПРОТИВООПУХОЛЕВОГО АНТРАЦИКЛИНА ДОКСОРУБИЦИНА ПРИ ХИМИОТЕРАПИИ ОПУХОЛЕЙTarskikhM. M.ТарскихМ. М.
Russian Federation

PhD, Associate Professor, Department of Physiology and Training Method of Biology, Krasnoyarsk State Pedagogical University named after V.P. Astaf’ev Address: 660049, Krasnoyarsk, Ady Lebedevoj St., 89; tel.: (391) 217-17-23

mtarskih@mail.ruShumbasovM. A.ШумбасовМ. А.
Russian Federation

Oncologist, Head of the Day Hospital, Krasnoyarsk regional oncologic dispensary named after A.I. Kryzhanowski Address: 660333, Krasnoyarsk, Pervaya Smolenskaya St., 16; tel.: (391) 264-68-21, (391) 299-20-06

shumbasov.max@rambler.ruKolesnikovS. I.КолесниковС. И.
Russian Federation

RAMS academician, Advisor of Presidium RAMS Honored Worker of Science of Russian Federation

sikolesnikov2012@gmail.comScientific Center of the Health Family Problems and Reproduction of Man, Irkutsk, the Russian FederationНаучный центр проблем здоровья семьи и репродукции человека, Иркутск, Российская Федерация22022013682Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук636607082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/217

Statistical analysis within the 20-year period showed that approximately 49% of workers who were exposed to widespread industrial poison acrylonitrile subsequently died from malignancy of different localization. The conducted experimental investigations demonstrated that acrylonitrile with the subacute intoxication of animals, the anti-tumor antibiotic doxorubicin, their combination, interwoven tumor and tumor developed against the background the introduction of acrylate and subsequent treatment doxorubicin led to onset of free-radical reactions. These reactions by themselves might stimulate development of malignancy. This fact confirms the need for antioxidant tracking of chemotherapy of tumors in the similar clinical cases.

Статистический анализ за 20-летний период показал, что примерно 49% лиц, работавших в контакте с широко распространенным промышленным ядом акрилонитрилом, впоследствии погибли от злокачественных новообразований различной локализации. Проведенные экспериментальные исследования продемонстрировали, что акрилонитрил при подострой интоксикации животных, противоопухолевый антибиотик доксорубицин, их комбинация, перевитая опухоль, а также опухоль, развившаяся на фоне введения акрилата и последующего лечения доксорубицином, приводят к запуску свободнорадикальных реакций, что само по себе может стимулировать развитие злокачественных опухолей. Это свидетельствует о необходимости антиоксидантного сопровождения химиотерапии опухолей в аналогичных клинических ситуациях.

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