AUTOCHTHONOUS PROBIOTICS IN PREVENTION OF INFECTIOUS AND INFLAMMATORY DISEASES OF A HUMAN IN THE ALTERED HABITATS

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Abstract

Dysbiotic shifts in intestinal and pharyngeal microflora were studied in 22 normal volunteers in 9-, 14-, 105- and 520-d chamber experiments simulating some of the spaceflight factors. Two preparations were administered to prevent pharyngeal and intestinal dysbiosis: oral dry probiotic based on indigenous intestinal Enterococci and topical collagen-immobilized Lactobacterin based on indigenous intestinal Lactobacilli. Topical autoprobiotic lactobacterin reduced the growth of opportunistic pathogens in the throat during the experiments. Oral autoprobiotic based on Enterococci reduced the content of intestinal opportunistic pathogens, supporting the high level of protecting microflora. Most of autostrains are free from pathogenicity factors, nevertheless, implementation of genetic testing of indigenous strains are reasonable.

 

About the authors

V. K. Il'in

State scientific center of Russian Federation — Institute of Biomedical Problems of RAS, Moscow, Russian Federation

Author for correspondence.
Email: ilyin@imbp.ru
PhD, Professor, head of the department of sanitary and hygienic human security in artificial environment, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-65-54 Russian Federation

A. N. Suvorov

Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences, St.Petersburg, Russian Federation

Email: alexander_suvorov1@hotmail.ru
PhD, Professor, Head of the Department of Molecular Microbiology, Research Institute of Experimental Medicine RAMS Address: 197376, St. Petersburg, Acad. Pavlova St., 12; tel.: (812) 234-93-19

N. V. Kiryukhina

State scientific center of Russian Federation — Institute of Biomedical Problems of RAS, Moscow, Russian Federation

Email: kiryukhina_nataliya@hotmail.com
PhD, Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36 Russian Federation

N. A. Usanova

State scientific center of Russian Federation — Institute of Biomedical Problems of RAS, Moscow, Russian Federation

Email: usanova@imbp.ru

Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36

Russian Federation

L. V. Starkova

State scientific center of Russian Federation — Institute of Biomedical Problems of RAS, Moscow, Russian Federation

Email: starkova@imbp.ru
PhD, Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36 Russian Federation

V. V. Boyarintsev

Clinical Hospital № 1 (Volynskaya), Moscow, Russian Federation

Email: wpx@mail.ru
PhD,Professor, Head Physician of Clinical Hospital No. 1 (Volynskaya) Department for Presidential Affairs of the Russian Federation Address: 121352, Moscow, Starovolynskaya St., 10; tel.: (495) 441-80-01 Russian Federation

A. B. Karaseva

Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences, St.Petersburg, Russian Federation

Email: tarno@list.ru

Research Worker, Department of Molecular Microbiology, Research Institute of Experimental Medicine RAMS Address: 197376, St. Petersburg, Acad. Pavlova St., 12; tel.: (812) 234-93-19

Russian Federation

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