Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC21610.15690/vramn.v68i2.550AUTOCHTHONOUS PROBIOTICS IN PREVENTION OF INFECTIOUS AND INFLAMMATORY DISEASES OF A HUMAN IN THE ALTERED HABITATSIl'inV. K.PhD, Professor, head of the department of sanitary and hygienic human security in artificial environment, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-65-54ilyin@imbp.ruSuvorovA. N.PhD, Professor, Head of the Department of Molecular Microbiology, Research Institute of Experimental Medicine RAMS Address: 197376, St. Petersburg, Acad. Pavlova St., 12; tel.: (812) 234-93-19alexander_suvorov1@hotmail.ruKiryukhinaN. V.PhD, Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36kiryukhina_nataliya@hotmail.comUsanovaN. A.<p>Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36</p>usanova@imbp.ruStarkovaL. V.PhD, Research Worker, Laboratory of Microbial Human Ecology, Institute of Biomedical Problems RAS Address: 123007, Moscow, Khoroshevskoe Highway, 76a; tel.: (499) 195-68-36starkova@imbp.ruBoyarintsevV. V.PhD,Professor, Head Physician of Clinical Hospital No. 1 (Volynskaya) Department for Presidential Affairs of the Russian Federation Address: 121352, Moscow, Starovolynskaya St., 10; tel.: (495) 441-80-01wpx@mail.ruKarasevaA. B.<p>Research Worker, Department of Molecular Microbiology, Research Institute of Experimental Medicine RAMS Address: 197376, St. Petersburg, Acad. Pavlova St., 12; tel.: (812) 234-93-19</p>tarno@list.ruState scientific center of Russian Federation — Institute of Biomedical Problems of RAS, Moscow, Russian FederationInstitute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences, St.Petersburg, Russian FederationClinical Hospital № 1 (Volynskaya), Moscow, Russian Federation22022013682566207082015Copyright © 1970, "Paediatrician" Publishers LLC1970<p class="Text05"><em>Dysbiotic shifts in intestinal and pharyngeal microflora were studied in 22 normal volunteers in 9-, 14-,</em> <em>105- and 520-d chamber experiments simulating some of the spaceflight factors. Two preparations were administered to prevent pharyngeal and intestinal dysbiosis: oral dry probiotic based on indigenous intestinal Enterococci and topical collagen-immobilized Lactobacterin based on indigenous intestinal Lactobacilli. Topical autoprobiotic lactobacterin reduced the growth of opportunistic pathogens in the throat during the experiments. Oral autoprobiotic based on Enterococci reduced the content of intestinal opportunistic pathogens, supporting the high level of protecting microflora. Most of autostrains are free from pathogenicity factors, nevertheless, implementation of genetic testing of indigenous strains are reasonable.</em></p><p> </p>autostrainsautoprobioticsaltered habitatimitation of space flightdisruption of colonization resistanceаутоштаммыаутопробиотикидисбактериозизмененные условия обитанияимитация факторов космического полетанарушение колонизационной резистентности[1. Liz'ko N.N. Dysbacterioses extreme states. Antibiotiki i med. biotekhnologiya = Antibiotics and medical biotechnology. 1987. 32, (3): 184-186.][2. Il'in V.K., Volozhin A.I., Vikha G.V. 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Volozhin A.I., Il'in V.K., Maksimovskii Yu.M., Istranov L.P., Istranova E.V., Aboyants R.K. Development and application of periodontal dressings of collagen and cell suspension Lactobacillus casei 37 in treatment of inflammatory periodontal diseases (results of microbiological tests). Stomatologiya: dvukhmesyachnyi nauchn.-prakt. zhurn. = Dentistry: bimonthly research and practical journal. 2004; 83 (6): 6–8.][15. Sidorenko A.B. Primenenie laktobakterina, immobilizovannogo na kollagene, dlya povysheniya effektivnosti lecheniya parodontita u bol'nykh sakharnym diabetom 2-go tipa s patologiei serdechno-sosudistoi sistemy. Avtoref. dis. … kand. med. nauk [Application laktobakterina immobilized on collagen, to improve the effectiveness of treatment of periodontitis in patients with Type 2 diabetes with the pathology of the cardiovascular system. Author’s abstract]. Moscow, 2005.]