TOXICOLOGICAL EVALUATION OF NANODISPERSED MANGANESE OXIDE (III, IV) EFFECT ON MORPHOLOGICAL PECULIARITIES OF DIFFERENT TISSUES UNDER EXPERIMENT

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  • Authors: Zaitseva N.V.1, Zemlyanova M.A.1, Zvezdin V.N.1, Lebedinskaya O.V.2, Melekhin S.V.2, Saenko E.V.3, Makhmudov R.R.1
  • Affiliations:
    1. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation
    2. E.A. Wagner Perm State Medical Academy, Perm, Russian Federation
    3. Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, Perm, Russian Federation
  • Issue: Vol 68, No 2 (2013)
  • Pages: 18-23
  • Section: HYGIENE: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/210
  • DOI: https://doi.org/10.15690/vramn.v68i2.544
  • Cite item

Abstract


The study of morphological features of tissue organs of experimental animals after a single intragastric administration of an aqueous suspension nanodis-dispersed manganese (III, IV) at doses of 2000, 3500 and 5000 mg/kg showed complex of morphological changes in the form of circulatory disorders up to hemostasis and bleeding which lead to changes in the structure of organs, enhanced apoptosis, activation of macrophage system by proliferation and macrophage phagocytosis of degradation products of cells, hypertrophy of lymphoid tissue of immune system; development of histiocytic infiltrates in parenchymal organs and central nervous system. With the introduction of microsized analogues in the same doses of the morphological changes in the circulatory system, macrophage system and immune organs found predominantly in a dose of 5000 mg/kg. Changes were less significant and were presented as activation of macrophages in the liver in the form of activation of Kupffer cells, proliferation of lymphoid tissue in the spleen, lymph histiocytic infiltrates in the liver, kidney, medium size.


N. V. Zaitseva

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Author for correspondence.
Email: root@fcrisk.ru

Russian Federation

PhD, Professor, RAMS academician, Honored Worker of Science of Russian Federation, Director of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34

M. A. Zemlyanova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: zem@fcrisk.ru

Russian Federation PhD, Head of Department of Biochemical and Сytogenetic Diagnostics Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 236-39-30

V. N. Zvezdin

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: zvezdin@fcrisk.ru

Russian Federation Junior Research Worker, Cytogenetics laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34

O. V. Lebedinskaya

E.A. Wagner Perm State Medical Academy, Perm, Russian Federation

Email: lebedinska@mail.ru

Russian Federation PhD, Associate Professor, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30

S. V. Melekhin

E.A. Wagner Perm State Medical Academy, Perm, Russian Federation

Email: rector@psma.ru

Russian Federation Assistant, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30

E. V. Saenko

Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, Perm, Russian Federation

Email: saenko_ekaterina@mail.ru

Russian Federation PhD, Senior Research Worker, Laboratory of Multiphase Dispersible Systems, Institute of Technical Chemistry Ural Branch of Russian Academy of Sciences Address: 614013, Perm, Ac. Koroleva St., 3, tel.: (342) 237-82-72

R. R. Makhmudov

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: bav@psu.ru

Russian Federation

PhD, Senior Research Worker, Metabolism and Pharmacokinetics Research Laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Ordzhonikidze St., 82; tel.: (342) 237-25-34

  1. Programma razvitiya nanoindustrii v Rossiiskoi Federatsii do 2015 g. (Development Programme nanotechnology industry in the Russian Federation until 2015). Available at: http://www.portalnano.ru/read/documents/met/mon-sm-538_16_16072010/program_2015 (accessed October 08, 2012).
  2. Marketingovoe issledovanie rynka nanoporoshkov (ver. 5): Analiticheskii otchet ot 16.12.2011 (Market research nanopowders (ver. 5): Analytical report dated December 16, 2011). Available at: http://www.research-techart.ru-/report-/nanopowder-market.htm (accessed October 02, 2012).
  3. Onishchenko G.G. Security strategy of the nanotechnology industry. Zdorov'e naseleniya i sreda obitaniya = Public health and environment. 2011; 5: 4–8.
  4. Onishchenko G.G., Zaitseva N.V., Zemlyanova M.A. Gigienicheskaya identifikatsiya posledstvii dlya zdorov'ya pri vneshnesredovoi ekspozitsii khimicheskikh faktorov. Pod red. G.G. Onishchenko [Hygienic identification of health effects at exposure of exogenous chemical factors. Edited by G.G. Onishchenko]. Perm, Knizhnyi format, 2011. 529 p.
  5. Zaitseva N.V., Zemlyanova M.A., Zvezdin V.N., Saenko E.V., Tarantin A.V., Makhmudov R.R., Lebedinskaya O.V., Melekhin S.V., Akaf'eva T.I. Toxicological and hygienic safety assessment and nanosized ultrafine manganese oxide (III, IV). Voprosy pitaniya = Nutrition. 2012; 5; 81: 13–19.
  6. Gyrdasova O.I., Krasil'nikov V.N., Bazuev G.V. Synthesis of nanoscale oxides of manganese from manganese oxalates hydrated and products of their chemical modification of ethylene glycol. Neorg. khimiya = Inorganic chemistry. 2009; 7: 1097–1102.
  7. Uaitsaids Dzh., Eigler D., Anders R. Nanotekhnologiya v blizhaishem desyatiletii. Prognoz napravleniya issledovanii. Pod red. M.K. Roko, R.S. Uil'yamsa i P. Alivisatosa. Per. s angl [Nanotechnology in the Next Decade. Forecast Research Directions. Edited by M.K. Roco, R.S. Williams and P. Alivisatos. Translated from English]. Moscow, Mir, 2002. 292 p.
  8. Greg S., Sing K. Adsorbtsiya, udel'naya poverkhnost', poristost'. Per. s angl [Adsorption, Surface Area, Porosity. Translated from English]. Moscow, Mir, 1984. 306 p.
  9. Lison D., Lardot C., Huaux F., Zanetti G., Fubini B. Infuence of partice surface area on the toxicity of insoluble manganese dioxide dusts. Arch. Toxicol. 1997; 71: 725–729.
  10. Oberdorster G. Nanotoxicology: Am emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspective. 2005; 7: 823–839.
  11. Pahl H.L. Activators and target genes of Rel/NF-kB transcription factors. Oncogene. 1999; 18: 6853–6866.
  12. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., Nakano H. NF-kB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003; 22: 3898–3909.
  13. Oberdorster G., Sharp Z, Atudorei V. Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol. 2004; 16: 437–445.
  14. Ostiguy C., Malo S., Asselin P. Synthese des connaissances scientifiques sur les risques d’atteinte a la sante suite a une exposition professionnelle au manganese: rapport IRSST № 339. Montreal. 2003. 41 p.

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