Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC21010.15690/vramn.v68i2.544HYGIENE: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ГИГИЕНЫTOXICOLOGICAL EVALUATION OF NANODISPERSED MANGANESE OXIDE (III, IV) EFFECT ON MORPHOLOGICAL PECULIARITIES OF DIFFERENT TISSUES UNDER EXPERIMENTМОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ТКАНЕЙ ВНУТРЕННИХ ОРГАНОВ И СИСТЕМ ПРИ ВОЗДЕЙСТВИИ НАНОДИСПЕРСНОГО ОКСИДА МАРГАНЦА (III, IV)ZaitsevaN. V.ЗайцеваН. В.
Russian Federation

PhD, Professor, RAMS academician, Honored Worker of Science of Russian Federation, Director of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34

root@fcrisk.ruZemlyanovaM. A.ЗемляноваМ. А.
Russian Federation

PhD, Head of Department of Biochemical and Сytogenetic Diagnostics Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 236-39-30

zem@fcrisk.ruZvezdinV. N.ЗвездинВ. Н.
Russian Federation

Junior Research Worker, Cytogenetics laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34

zvezdin@fcrisk.ruLebedinskayaO. V.ЛебединскаяО. В.
Russian Federation

PhD, Associate Professor, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30

lebedinska@mail.ruMelekhinS. V.МелехинС. В.
Russian Federation

Assistant, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30

rector@psma.ruSaenkoE. V.СаенкоЕ. В.
Russian Federation

PhD, Senior Research Worker, Laboratory of Multiphase Dispersible Systems, Institute of Technical Chemistry Ural Branch of Russian Academy of Sciences Address: 614013, Perm, Ac. Koroleva St., 3, tel.: (342) 237-82-72

saenko_ekaterina@mail.ruMakhmudovR. R.МахмудовР. Р.
Russian Federation

PhD, Senior Research Worker, Metabolism and Pharmacokinetics Research Laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Ordzhonikidze St., 82; tel.: (342) 237-25-34

bav@psu.ruFederal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian FederationФедеральный научный центр медико-профилактических технологий управления рисками здоровью населения, Пермь, Российская ФедерацияE.A. Wagner Perm State Medical Academy, Perm, Russian FederationПермская государственная медицинская академия им. акад. Е.А. Вагнера, Российская ФедерацияInstitute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, Perm, Russian FederationИнститут технической химии Уральского отделения РАН, Пермь, Российская ФедерацияFederal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian FederationФедеральный научный центр медико-профилактических технологий управления рисками здоровью населения, Пермь, Российская Федерация22022013682Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук182307082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/210

The study of morphological features of tissue organs of experimental animals after a single intragastric administration of an aqueous suspension nanodis-dispersed manganese (III, IV) at doses of 2000, 3500 and 5000 mg/kg showed complex of morphological changes in the form of circulatory disorders up to hemostasis and bleeding which lead to changes in the structure of organs, enhanced apoptosis, activation of macrophage system by proliferation and macrophage phagocytosis of degradation products of cells, hypertrophy of lymphoid tissue of immune system; development of histiocytic infiltrates in parenchymal organs and central nervous system. With the introduction of microsized analogues in the same doses of the morphological changes in the circulatory system, macrophage system and immune organs found predominantly in a dose of 5000 mg/kg. Changes were less significant and were presented as activation of macrophages in the liver in the form of activation of Kupffer cells, proliferation of lymphoid tissue in the spleen, lymph histiocytic infiltrates in the liver, kidney, medium size.

Исследование морфологических особенностей тканей внутренних органов экспериментальных животных при однократном внутрижелудочном введении водной суспензии нанодисперсного оксида марганца (III, IV) в дозах 2000, 3500 и 5000 мг/кг продемонстрировало комплекс морфологических изменений в виде нарушения кровообращения вплоть до стаза крови и кровоизлияний, приводящих к изменению структуры органов, усиленному апоптозу клеток; активизацию макрофагальной системы в виде пролиферации и фагоцитоза макрофагами продуктов разрушения клеток; гипертрофию лимфоидной ткани в органах иммуногенеза и формирование лимфогистиоцитарных инфильтратов в паренхиматозных органах, органах центральной нервной системы. В случае введения микроразмерного аналога в тех же дозах морфологические изменения в системе кровообращения, макрофагальной системе и органах иммуногенеза обнаружены преимущественно при применении дозы в 5000 мг/кг. Изменения носили значительно менее выраженный характер и заключались в активации макрофагальной системы в печени в виде активизации клеток Купфера, пролиферации лимфоидной ткани в селезенке, лимфогистиоцитарных инфильтратов средних размеров в печени и почках.

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