PARAMETERS ASSOCIATED WITH ABSENCE OF SIGNIFICANT CORONARY ATHEROSCLEROSIS BY DATA OF REGISTER OF PROVIDED CORONARY ANGIOGRAPHY

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Abstract

Aim of the study: the study aimed to reveal the sign of coronary atherosclerosis absence using the factor analysis in patients referred for the coronary angiography. Patients and methods: 9409 patients suspected stable coronary artery disease (CAD) or with confirmed diagnosis of CAD from the «Registry of provided coronary angiography» were included in the study. Results of the study: principal factor described about 59% of the variation and included the burdens of 4 parameters (gender, smoking, significant coronary atherosclerosis and hypothyroidism) and was interpreted as factor of coronary atherosclerosis. Conclusions: it was found that the absence of coronary stenosis was associated with female gender, non-smoking status and hypothyroidism.

 

About the authors

V. A. Kuznetsov

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Author for correspondence.
Email: vadkuznetsov@rambler.ru
PhD, director, Head of the science division of instrumental methods of research of the Branch of Federal State Budgetary Institution «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center» Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08 Россия

E. I. Yaroslavskaya

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Email: yaroslavskayae@gmail.com
MD, senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center», physician of ultrasonic diagnosis. Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08 Россия

E. A. Gorbatenko

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Email: pushcarov@mail.ru
research assistant of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08 Россия

M. V. Varshavchik

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Email: varshavchic@cardio.tmn.ru
endocrinologist of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 40-97-16 Россия

D. V. Krinochkin

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Email: krin@cardio.tmn.ru
MD, senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center» Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 75-97-22 Россия

G. V. Kolunin

Tyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian Federation

Email: kolunin@cardio.tmn.ru
senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research, head of department of X-ray surgical methods of diagnosis and treatment No. 2 of the Branch of of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08 Россия

R. S. Karpov

Institute of Cardiology, Siberian Branch of RAMS, Tomsk, Russian Federation

Email: tvk@cardio.tsu.ru
member of RAMS, director of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS. Address: 111A, Kievskaya St., Tomsk, 634012, tel.: (3822) 55-34-49, e-mail: tvk@cardio.tsu.ru Россия

References

  1. Akchurin R.S., Vasyuk Yu.A., Karpov Yu.A. Lupanov V.P., Martsevich S.Yu., Pozdnyakov Yu.M. et al. National guidelines for the diagnosis and treatment of stable angina. 2008. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention. 2008; 7(6): Appendix 4.
  2. Gaziano J.M. Global burden of cardiovascular disease. In: Braunwald E., Libby P., Bonow R.O., Mann D.L., Zipes D.P. (eds). Braunwald’s heart disease: a textbook of cardiovascular medicine. 8th ed. Philadelphia: Saunders Elsevier. 2008. р. 1-22.
  3. Pries A.R., Habazettl H., Ambrosio G., Hansen P.R., Kaski J.C., Schächinger V. et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. Cardiovasc. Res. 2008; 80 (2): 165–174.
  4. Yang E.H., Lerman A. Angina pectoris with a normal coronary angiogram. Herz. 2005; 30 (1): 17–25.
  5. Kuznetsov V.A., Zyryanov I.P., Kolunin G.V., Krinochkin D.V., Semukhin M.V., Panin A.V. etc. Registr provedennykh operatsiy koronarnoy angiografii. Svidetelstvo o gosudarstvennoy registratsii bazy dannykh. [Register of Performed Coronary Angiography Surgeries. Certificate of State Registration Database]. Moscow, 2010.
  6. Braverman L.I. Bolezni shchitovidnoy zhelezy. [Thyroid Diseases]. Мoscow, Меditsina, 2000. 432 p.
  7. Dedov I.I., Melnichenko G.A., Fadeev V.V. Endokrinologiya. [Endocrinology]. Мoscow, GEOTAR-Меdiа, 2007. 432 p.
  8. Shiller N., Osipov M.A. Klinicheskaya ekhokardiografiya. [Clinical Echocardiography]. Мoscow, Praktika, 2005. 344 p.
  9. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur. Heart J. 2012; 33 (13): 1635–1701.
  10. Kim J.-О., Muller Ch.W., Klecka U.R. Faktornyy, diskriminantnyy i klasternyy analiz. [Factor, Discriminant and Cluster Analysis]. Мoscow, Finansy i statistika, 1989. 216 p.
  11. McQuade C., Skugor M., Brennan D.M., Hoar B., Stevenson C., Hoogwerf B.J. Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a PreCIS database study. Thyroid. 2011; 21 (8): 837–843.
  12. Kuznetsov V.A., Yaroslavskaya E.I., Zyryanov I.P. et al. Comparative characteristics of patients with coronary heart disease of middle and old age in the absence of hemodynamically significant stenosis of epicardial coronary arteries. Serdtse = Heart. 2010; 3(9): 150–155.
  13. Yaroslavskaya E.I., Kuznetsov V.A., Pushkarev G.S., Kolunin G.V., Krinochkin D.V., Gorbatenko E.A. et al. Hypothyroidism as a predictor of the absence of significant coronary stenoses in elderly patients with coronary heart disease with stable angina. Klinicheskaya meditsina = Clinical medicine. 2012; 11: 34–39.
  14. Traub-Weidinger T., Graf S., Beheshti M., Ofluoglu S., Zettinig G., Khorsand A., et al. Coronary vasoreactivity in subjects with thyroid autoimmunity and subclinical hypothyroidism before and after supplementation with thyroxine. Thyroid. 2012; 22 (3): 245–251.
  15. Oflaz H., Kurt R., Sen F., Onur I., Cimen A.O., Elitok A., et al. Coronary flow reserve after L-thyroxine therapy in Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism. Endocrine. 2007; 32: 264–270.

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