Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC14510.15690/vramn.v68i9.775CARDIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИPARAMETERS ASSOCIATED WITH ABSENCE OF SIGNIFICANT CORONARY ATHEROSCLEROSIS BY DATA OF REGISTER OF PROVIDED CORONARY ANGIOGRAPHYПАРАМЕТРЫ, СВЯЗАННЫЕ С ОТСУТСТВИЕМ ЗНАЧИМОГО КОРОНАРНОГО АТЕРОСКЛЕРОЗА ПО ДАННЫМ «РЕГИСТРА ПРОВЕДЕННЫХ ОПЕРАЦИЙ КОРОНАРНОЙ АНГИОГРАФИИ»KuznetsovV. A.КузнецовВ. А.
Russian Federation

PhD, director, Head of the science division of instrumental methods of research of the Branch of Federal State Budgetary Institution «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center» Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08

vadkuznetsov@rambler.ruYaroslavskayaE. I.ЯрославскаяЕ. И.
Russian Federation

MD, senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center», physician of ultrasonic diagnosis. Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08

yaroslavskayae@gmail.comGorbatenkoE. A.ГорбатенкоЕ. А.
Russian Federation

research assistant of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08

pushcarov@mail.ruVarshavchikM. V.ВаршавчикМ. В.
Russian Federation

endocrinologist of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 40-97-16

varshavchic@cardio.tmn.ruKrinochkinD. V.КриночкинД. В.
Russian Federation

MD, senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research of the Branch of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center» Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 75-97-22

krin@cardio.tmn.ruKoluninG. V.КолунинГ. В.
Russian Federation

senior research scientist of the instrumental diagnostics laboratory the science division of instrumental methods of research, head of department of X-ray surgical methods of diagnosis and treatment No. 2 of the Branch of of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS «Tyumen Cardiology Center». Address: 111, Melnikayte St., Tyumen, 625026, tel.: (3452) 20-76-08

kolunin@cardio.tmn.ruKarpovR. S.КарповР. С.
Russian Federation

member of RAMS, director of FSBI «Scientific Research Institute of Cardiology» under the Siberian Branch of RAMS. Address: 111A, Kievskaya St., Tomsk, 634012, tel.: (3822) 55-34-49, e-mail: tvk@cardio.tsu.ru

tvk@cardio.tsu.ruTyumen Cardiology Centre, Branch of the Institute of Cardiology, Siberian Branch of RAMS, Tyumen, Russian FederationНаучно-исследовательский институт кардиологии СО РАМН, филиал «Тюменский кардиологический центр», Российская ФедерацияInstitute of Cardiology, Siberian Branch of RAMS, Tomsk, Russian FederationНаучно-исследовательский институт кардиологии СО РАМН, Томск, Российская Федерация10092013689Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук273107082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/145

Aim of the study: the study aimed to reveal the sign of coronary atherosclerosis absence using the factor analysis in patients referred for the coronary angiography. Patients and methods: 9409 patients suspected stable coronary artery disease (CAD) or with confirmed diagnosis of CAD from the «Registry of provided coronary angiography» were included in the study. Results of the study: principal factor described about 59% of the variation and included the burdens of 4 parameters (gender, smoking, significant coronary atherosclerosis and hypothyroidism) and was interpreted as factor of coronary atherosclerosis. Conclusions: it was found that the absence of coronary stenosis was associated with female gender, non-smoking status and hypothyroidism.

Цель исследования: используя факторный анализ, установить, какие признаки связаны с отсутствием коронарного атеросклероза у пациентов, направленных на коронарную ангиографию. Пациенты и методы: в исследование вошли 9409 стабильных пациентов из «Регистра проведенных операций коронарной ангиографии» как с подозрением на ишемическую болезнь сердца (ИБС), так и с установленным диагнозом ИБС. Результаты: было изучено 5 факторов, объясняющих до 59% вариабельности изучаемого явления. Первый, наиболее значимый фактор объяснял 14% общей дисперсии, содержал нагрузки 4 переменных (пол пациента, курение, значимый коронарный атеросклероз и гипофункция щитовидной железы) и интерпретировался как фактор коронарного атеросклероза. Выводы: продемонстрирована связь отсутствия коронарного атеросклероза с женским полом, отсутствием курения и наличием гипофункции щитовидной железы.

coronary atherosclerosishypothyroidismfactor analysisкоронарный атеросклерозгипофункция щитовидной железыфакторный анализ1. Akchurin R.S., Vasyuk Yu.A., Karpov Yu.A. Lupanov V.P., Martsevich S.Yu., Pozdnyakov Yu.M. et al. National guidelines for the diagnosis and treatment of stable angina. 2008. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention. 2008; 7(6): Appendix 4.2. Gaziano J.M. Global burden of cardiovascular disease. In: Braunwald E., Libby P., Bonow R.O., Mann D.L., Zipes D.P. (eds). Braunwald’s heart disease: a textbook of cardiovascular medicine. 8th ed. Philadelphia: Saunders Elsevier. 2008. р. 1-22.3. Pries A.R., Habazettl H., Ambrosio G., Hansen P.R., Kaski J.C., Schächinger V. et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. Cardiovasc. Res. 2008; 80 (2): 165–174.4. Yang E.H., Lerman A. Angina pectoris with a normal coronary angiogram. Herz. 2005; 30 (1): 17–25.5. Kuznetsov V.A., Zyryanov I.P., Kolunin G.V., Krinochkin D.V., Semukhin M.V., Panin A.V. etc. Registr provedennykh operatsiy koronarnoy angiografii. Svidetelstvo o gosudarstvennoy registratsii bazy dannykh. [Register of Performed Coronary Angiography Surgeries. Certificate of State Registration Database]. Moscow, 2010.6. Braverman L.I. Bolezni shchitovidnoy zhelezy. [Thyroid Diseases]. Мoscow, Меditsina, 2000. 432 p.7. Dedov I.I., Melnichenko G.A., Fadeev V.V. Endokrinologiya. [Endocrinology]. Мoscow, GEOTAR-Меdiа, 2007. 432 p.8. Shiller N., Osipov M.A. Klinicheskaya ekhokardiografiya. [Clinical Echocardiography]. Мoscow, Praktika, 2005. 344 p.9. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur. Heart J. 2012; 33 (13): 1635–1701.10. Kim J.-О., Muller Ch.W., Klecka U.R. Faktornyy, diskriminantnyy i klasternyy analiz. [Factor, Discriminant and Cluster Analysis]. Мoscow, Finansy i statistika, 1989. 216 p.11. McQuade C., Skugor M., Brennan D.M., Hoar B., Stevenson C., Hoogwerf B.J. Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a PreCIS database study. Thyroid. 2011; 21 (8): 837–843.12. Kuznetsov V.A., Yaroslavskaya E.I., Zyryanov I.P. et al. Comparative characteristics of patients with coronary heart disease of middle and old age in the absence of hemodynamically significant stenosis of epicardial coronary arteries. Serdtse = Heart. 2010; 3(9): 150–155.13. Yaroslavskaya E.I., Kuznetsov V.A., Pushkarev G.S., Kolunin G.V., Krinochkin D.V., Gorbatenko E.A. et al. Hypothyroidism as a predictor of the absence of significant coronary stenoses in elderly patients with coronary heart disease with stable angina. Klinicheskaya meditsina = Clinical medicine. 2012; 11: 34–39.14. Traub-Weidinger T., Graf S., Beheshti M., Ofluoglu S., Zettinig G., Khorsand A., et al. Coronary vasoreactivity in subjects with thyroid autoimmunity and subclinical hypothyroidism before and after supplementation with thyroxine. Thyroid. 2012; 22 (3): 245–251.15. Oflaz H., Kurt R., Sen F., Onur I., Cimen A.O., Elitok A., et al. Coronary flow reserve after L-thyroxine therapy in Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism. Endocrine. 2007; 32: 264–270.