AGE AND SEXUAL CHANGES STRUCTURE OF GENES CYTOKINES NETWORKS IN RUSSIAN POPULATION

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Abstract

Objective: to study frequencies of occurrence of the combined genetic attributes including different variants of cytokines genotypes (TNFA, IL1B, IL4, IL6, IL10, VEGF), in different on sexual  and age groups in population of Siberia Caucasoid. Material and methods. Frequencies of distribution of variants of structure genes cytokines networks  among 500 representatives of Siberia  Caucasian population, men and women  of  two age groups - more younger than 35 years ("young") and 55 and more years ("elderly") are  investigated. In structure of  investigated genes cytokines net  has come 10 variants of polymorphic sites of cytokines genes and  vascular endothelial growth factor gene: TNFА-863 C→A, TNFА-308 G→A, TNFА-238 G→A, IL1B-31 С→T, IL4-590 С→T, IL6-174 G→C, IL10-1082 G → A, IL10-592 А→С, VEGF-2578 C→A and VEGF+936 С→T. Genotyping are carried out by  restriction fragment length polymorphism method. Processing of results carried out on the basis of the original methodological approach including the complex connected computer analysis of genic circuits of various dimension. Results and conclusions. It is shown, that the significant part of variants genes cytokines networks, which   widely distributed among young people is completely absent in the "elderly" age group. Such variants disappearing with age separately for men and women are established. At the program mathematical analysis it is established, that parameters of the odds ratio  achieve two-place sizes (OR =27, p =0,0004), that testifies to high specificity of complex genetic attributes. Presence in genome such variants of genes cytokines networks  , found out in the childhood or young age, as supposed, is unfavorable personalized prognostic factors of life span of the individual.

 

About the authors

V. I. Konenkov

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Author for correspondence.
Email: konenkov@soramn.ru
PhD, professor, member of RAMS, Head of the Clinical Immunogenetics Laboratory, director of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Россия

V. F. Prokof'ev

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Email: vprok@ngs.ru
MD, leading research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Россия

A. V. Shevchenko

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Email: shalla64@mail.ru
MD, senior research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Россия

A. M. Chernyavskii

Scientific Research Institute of a Pathology of Blood Circulation named after E.N. Meshalkin of the Health Ministries of Russian Federation, Novosibirsk, Russian Federation

Email: tsvelo@mail.ru
PhD, professor, Head of the Center of Aortic Surgery, coronary and peripheral arteries of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58 Россия

A. M. Karas'kov

Scientific Research Institute of a Pathology of Blood Circulation named after E.N. Meshalkin of the Health Ministries of Russian Federation, Novosibirsk, Russian Federation

Email: tsvelo@mail.ru
PhD, professor, member of RAMS, director of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58 Россия

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