Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC14310.15690/vramn.v68i9.773AGE AND SEXUAL CHANGES STRUCTURE OF GENES CYTOKINES NETWORKS IN RUSSIAN POPULATIONKonenkovV. I.PhD, professor, member of RAMS, Head of the Clinical Immunogenetics Laboratory, director of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94konenkov@soramn.ruProkof'evV. F.MD, leading research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94vprok@ngs.ruShevchenkoA. V.MD, senior research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94shalla64@mail.ruChernyavskiiA. M.PhD, professor, Head of the Center of Aortic Surgery, coronary and peripheral arteries of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58tsvelo@mail.ruKaras'kovA. M.PhD, professor, member of RAMS, director of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58tsvelo@mail.ruScientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian FederationScientific Research Institute of a Pathology of Blood Circulation named after E.N. Meshalkin of the Health Ministries of Russian Federation, Novosibirsk, Russian Federation10092013689152107082015Copyright © 1970, "Paediatrician" Publishers LLC1970<strong><em>Objective:</em></strong><em> to study frequencies of occurrence of the combined genetic attributes including different variants of cytokines genotypes (TNFA, IL1B, IL4, IL6, IL10, VEGF), in different on</em><em> </em><em>sexual and age groups in population of Siberia Caucasoid. <strong>Material and methods.</strong> Frequencies of distribution of variants of structure genes cytokines networks among 500 representatives of Siberia Caucasian population, men and women of two age groups - more younger than 35 years ("young") and 55 and more years ("elderly") are investigated. In structure of investigated genes cytokines net has come 10 variants of polymorphic sites of cytokines genes and vascular endothelial growth factor gene: TNFА-863 C→A, TNFА-308 G→A, TNFА-238 G→A, IL1B-31 С→T, IL4-590 С→T, IL6-174 G→C, IL10-1082 G → A, IL10-592 А</em><em>→С</em><em>, VEGF-2578 C→A and VEGF+936 С→T. Genotyping are carried out by </em><em>restriction fragment length polymorphism</em><em> method. Processing of results carried out on the basis of the original methodological approach including the complex connected computer analysis of genic circuits of various dimension. </em><strong><em>Results and conclusions.</em></strong><em> It is shown, that the significant part of variants genes cytokines networks, which widely distributed among young people is completely absent in the "elderly" age group. Such variants disappearing with age separately for men and women are established. At the program mathematical analysis it is established, that parameters of the odds ratio achieve two-place sizes (OR =27, p =0,0004), that testifies to high specificity of complex genetic attributes. Presence in genome such variants of genes cytokines networks , found out in the childhood or young age, as supposed, is unfavorable personalized prognostic factors of life span of the individual.</em><p class="Text05"> </p>structure of genes cytokines networkssexual and age distinctionsRussian populationструктура цитокиновой генной сетиполовые и возрастные различиянаселение России[1. Strategiya razvitiya meditsinskoi nauki v Rossiiskoi Federatsii na period do 2025 goda. [The Strategy for the Development of Medical Science in the Russian Federation for the Period up to 2025]. Moscow, Ministry of Health of the Russian Federation, 2012. 17 p.][2. Konenkov V.I., Korolev M.A., Shevchenko A.V., Lapsina S.A., Koroleva E.A., Zonova E.V., Prokof'ev V.F. 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