The Role of Extracellular Vesicles of Various Origins in the Development of Preeclampsia

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Pre-eclampsia is a clinically unfavorable pregnancy outcome that determines the main indicators of maternal and/or perinatal morbidity and mortality. According to modern concepts, the placenta plays a central role in the development of PE, while intercellular and intervesicular communications involving extracellular vesicles (EVs, extracellular vesicles) initiate a cascade of various biological effects, determining the mechanisms of ontogenesis of the gestational process in normal and pathological conditions. Achievements in studies of extracellular vesicles (EVs, extracellular vesicles) are of particular interest both to clinicians and to researchers studying the pathophysiology of gestational complications. Extracellular vesicles (EVs) in preeclampsia are produced both by scintiotrophoblast and the maternal body - blood cells (platelets, red blood cells, white blood cells) and the cardiovascular (vascular endothelium, smooth muscle) system. Changes in the concentration of these EVs can contribute to the implementation of preeclampsia, enhancing the pro-inflammatory and procoagulant states inherent in the gestation process. This review focuses on freely available information on the possible interactions between placental and maternal EVs. Understanding the contribution of EVs to the development of preeclampsia can help to deepen knowledge about the pathogenesis of this pathology and determine the diagnostic and prognostic significance of extracellular vesicles as biomarkers.

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Mariya G. Nikolaeva

Altai State Medical University; National Research Center for Hematology

Author for correspondence.
ORCID iD: 0000-0001-9459-5698
SPIN-code: 8295-9290
Scopus Author ID: 57191960907
ResearcherId: AAI-6271-2020

MD, PhD, Associate Professor

Russian Federation, 40 Lenina Av., 656038, Barnaul; Barnaul

Vasilisa U. Terekhina

Altai State Medical University

ORCID iD: 0000-0003-0695-6145
SPIN-code: 9359-1428


Russian Federation, 40 Lenina Av., 656038, Barnaul, Russia

Alexey V. Kudinov

National Research Center for Hematology

ORCID iD: 0000-0002-0967-6117
SPIN-code: 6231-4604
Scopus Author ID: 37102157300
ResearcherId: AAB-8493-2020

candidate of biological sciences

Russian Federation, Barnaul

Andrey P. Momot

Altai State Medical University; National Medical Research Center for Hematology

ORCID iD: 0000-0002-8413-5484
SPIN-code: 8464-9030
Scopus Author ID: 6603848680
ResearcherId: M-7923-2015

MD, PhD, Professor

Russian Federation, 40 Lenina Av., 656038, Barnaul; Barnaul


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