Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC136910.15690/vramn1369Research ArticleThe Role of Extracellular Vesicles of Various Origins in the Development of PreeclampsiaNikolaevaMariya G.<p>MD, PhD, Associate Professor</p>nikolmg@yandex.ruhttps://orcid.org/0000-0001-9459-5698TerekhinaVasilisa U.<p>assistant</p>vasutka_07@mail.ruhttps://orcid.org/0000-0003-0695-6145KudinovAlexey V.<p>candidate of biological sciences</p>kudinovalexej@gmail.comhttps://orcid.org/0000-0002-0967-6117MomotAndrey P.<p>MD, PhD, Professor</p>xyzan@yandex.ruhttps://orcid.org/0000-0002-8413-5484Altai State Medical UniversityNational Research Center for HematologyNational Medical Research Center for Hematology030920217632372430706202003052021Copyright © 2021, "Paediatrician" Publishers LLC2021<p>Pre-eclampsia is a clinically unfavorable pregnancy outcome that determines the main indicators of maternal and/or perinatal morbidity and mortality. According to modern concepts, the placenta plays a central role in the development of PE, while intercellular and intervesicular communications involving extracellular vesicles (EVs, extracellular vesicles) initiate a cascade of various biological effects, determining the mechanisms of ontogenesis of the gestational process in normal and pathological conditions. Achievements in studies of extracellular vesicles (EVs, extracellular vesicles) are of particular interest both to clinicians and to researchers studying the pathophysiology of gestational complications. Extracellular vesicles (EVs) in preeclampsia are produced both by scintiotrophoblast and the maternal body - blood cells (platelets, red blood cells, white blood cells) and the cardiovascular (vascular endothelium, smooth muscle) system. Changes in the concentration of these EVs can contribute to the implementation of preeclampsia, enhancing the pro-inflammatory and procoagulant states inherent in the gestation process. This review focuses on freely available information on the possible interactions between placental and maternal EVs. Understanding the contribution of EVs to the development of preeclampsia can help to deepen knowledge about the pathogenesis of this pathology and determine the diagnostic and prognostic significance of extracellular vesicles as biomarkers.</p>extracellular vesiclespreeclampsiascintiotrophoblasttissue factorэкстраклеточные везикулыпреэклампсиясинцитиотрофобласттканевой фактор[La Rocca C, Carbone F, Longobardi S, Matarese G. The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett. 2014;162(1):41–48. doi: https://doi.org/10.1016/J.IMLET.2014.06.013][Clemmens H, Lambert DW. Extracellular vesicles: Translational challenges and opportunities. Biochem Soc Trans. 2018;46(5):1073–1082. doi: https://doi.org/10.1042/BST20180112][Pieragostino D, Lanuti P, Cicalini I, et al. 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