NOSOCOMIAL RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN PRETERM INFANTS: CHARACTERISTICS OF THE COURSE, TREATMENT АND PREVENTION IN CLINICAL PRACTICE

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Abstract


Objective: to study the clinical, laboratory and radiological features of the course of nosocomial bronchiolitis respiratory syncytial viral (RSV ) etiology and effectiveness of the therapy in preterm infants in the neonatal hospital conditions. Patients and Methods: We analyzed case histories of 10 hospitalized patients who had RSV etiology bronchiolitis established by RIF / PCR in neonatal Moscow hospitals in  2011-2013. Results: RSV infection in hospitalized preterm infants with and without bronchopulmonary dysplasia runs hardly, requiring treatment in the intensive care unit, oxygen therapy and  lungs mechanical ventilation. The respiratory failure is the symptom of the of RSV bronchiolitis severity. X-ray picture of the disease is characterized by peribronchial changes, emphysematous swelling , segmental infiltration and bronchial obstruction (atelectasis, hypoventilation ). The frequency of bacterial complications of RSV bronchiolitis is low. In clinical practice newborns with severe RSV bronchiolitis are treated with antibiotics, bronchodilators, steroids. The timely isolation of patients can prevent the extention of the infection in the hospital. Conclusions: The preventive measures are needed to prevent the extention of RSV in neonatal hospitals, including specific immune prophylaxisof RSV infection in children at risk .



D. Yu. Ovsyannikov

Russian Peoples’ Friendship University, Moscow, Russian Federation

Author for correspondence.
Email: mdovsyannikov@yahoo.com

Russian Federation PhD, Head of the Department of Pediatrics of FSBI People’s Friendship University of Russia. Address: 6, Miklukho-Maklaya Street, Moscow, RF, 117198; tel.: +7 (499) 236-11-52

D. N. Degtyarev

V.I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

Email: glav_neolog@yahoo.com

Russian Federation PhD, professor, Deputy Director for Scientific Research of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”.Address: 4, Akad. Oparin Street, Moscow, RF, 117997; tel.: +7 (495) 531-44-44

I. I. Ryumina

V.I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

Email: i.ryumina@mail.ru

Russian Federation

PhD, professor, Head of the Department of Pathology of Newborns and Premature neonates of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”. Address: 4, Akad. Oparin Street, Moscow, RF, 117997; tel.: +7 (495) 531-44-44

I. V. Krsheminskaya

Russian Peoples’ Friendship University, Moscow, Russian Federation

Email: spatira@mail.ru

Russian Federation assistant of the Department of Pediatrics of FSBI People’s Friendship University of Russia. Address: 6, Miklukho-Maklaya Street, Moscow, RF, 117198; tel.: +7 (499) 154-03-33

I. V. Orlovskaya

V.I. Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

Email: secretariat@oparina4.ru

Russian Federation

MD, senior research scientist of the Department of Pathology of Newborns and Premature neonates of FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology”. Address: 4, Akad. Oparin Street, Moscow, RF, 117997; tel.: +7 (495) 531-44-44

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