ВНУТРИОРГАННЫЕ И ВНУТРИТКАНЕВЫЕ МЕХАНИЗМЫ РЕГУЛЯТОРНЫХ ВОЗДЕЙСТВИЙ КЛЕТОК КУПФЕРА НА ГЕПАТОЦИТЫ

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Аннотация

Активированные эндотоксином клетки Купфера выделяют в межклеточное пространство медиаторы, действующие на гепатоциты как прямо, так и опосредованно, при участии звездчатых клеток. В обоих случаях клетки Купфера оказывают свое регуляторное влияние паракринно. Однако регулируемая область паренхимы печени может быть увеличенна путем реализации нескольких механизмов. Одним из них является выброс вазоконстрикторов из активированных клеток Купфера, стимулирующих сократительную способность звездчатых клеток. Этот эффект может быть достигнут также путем формирования очагов гиперметаболизма под действием медиаторов клеток Купфера с последующей активацией гепатоцит–гепатоцитарных взаимодействий, основанных на принципе конкурирования клеток за кислород в межклеточном пространстве. Регуляторное влияние активированных клеток Купфера может распространяться в паренхиме печени и с использованием механизма внутритканевых гепатоцит–гепатоцитарных взаимодействий, реализующих реакцию тканевого стресса.

 

Об авторах

Г. М. Элбакидзе

Медико-биологический центр Ассоциации содействия международному центру научной культуры ― «Всемирная лаборатория», Москва, Российская Федерация

Автор, ответственный за переписку.
Email: gmelbakidze@hotmail.com

PhD, RANS academician, Director of Biomedical Center, Association for World Laboratory Address: 125057, Moscow, Leningradskii Prospect, 71-128; tel.: (499) 198-72-28

Россия

А. Г. Меденцев

Институт биохимии и физиологии микроорганизмов им. Г.К. Скрябина РАН, Московская область, Пущино, Российская Федерация

Email: medentsev-ag@rambler.ru

PhD., Head of the Laboratory of Microorganism Adaptation, Institute of Biochemistry and Physiology of Microorganisms named after G.K. Skryabin RAS Address: 142290, Moscow region, Pushchino, Nauki Avenue, 5; tel.: (495) 956-33-70

Россия

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