НЕРВНАЯ РЕГУЛЯЦИЯ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ

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Аннотация

В обзоре рассмотрены вопросы вегетативной регуляции функции щитовидной железы. Активация центральных α-адренергических механизмов увеличивает высвобождение тиреотропного гормона гипофиза преимущественно за счет стимуляции его секреции. Дофамин угнетает секрецию этого гормона, воздействуя на D2-рецепторы тиреотропоцитов. Ацетилхолин и другие холиномиметики угнетают функциональную активность тиреоцитов при участии мускариновых рецепторов. Наряду симпатическим и парасимпатическим отделом особое внимание уделено роли серотонинергического отдела вегеьтативной нервной системы. Серотонин может блокировать секрецию тиреотропина гипофизом, однако оказывает прямое стимулирующее влияние на тиреоциты. Этот стимуляторный эффект серотонина опосредован 5-НТ2-рецепторами. При гипотиреозе угнетен синтез и метаболизм серотонина в мозге. Депрессия сопровождается угнетением активности фермента дейодиназы типа 2, что способствует снижению содержания серотонина при депрессии. Активация 5-НТ1-рецептора приводит к увеличению содержания внутриклеточного кальция, вызывая торможение активности промоутера кальцитонин ген-ассоциированного пептида.

 

Об авторах

А. Э. Лычкова

Центральный научно-исследовательский институт гастроэнтерологии, Москва, Российская Федерация

Автор, ответственный за переписку.
Email: lychkova@mail.ru
PhD, Head of the Clinical Physiology Laboratory, Central Research Institute of Gastroenterology Department of Moscow Public Health Address: 129343, Moscow, Entuziastov highway, 86; tel.: (499) 180-41-12 Россия

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