FOOD SENSITIZATION IN CHILDREN WITH OPISTHORCHIS FELINEUS INVASION

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Abstract

Aim: to determine the mechanism of food sensitization in children with chronic Opisthorchis felineus invasion. Patients and methods: during the epidemiological study the groups of patients (7–10 years) with chronic opisthorchiasis (n =237) and children without chronic opisthorchiasis (n =496) were formed. The investigation included interviewing of parents / guardians, measurement of total IgE, specific IgE to food allergens and component-resolved diagnostic, real-time PCR in stool samples. Results: the chronic opisthorchiasis invasion in children is associated with reduced risk of food sensitization, compared with non-infected group (9,7 vs 16,94%, OR =0,53; 95% CI 0,31–0,88; p =0,01). Opisthorchiasis of high intensity negatively correlated with increased level of specific IgE to food allergens in serum (OR =0,46; 95% CI 0,24–0,91; p =0,023). The association between level of total IgE and intensity of opisthorchiasis combinated with food sensitization was found. The sensitization to allergens class I (cyp c1, cor a11, gal d2, pru p3) is more prevalent in patients with opisthorchiasis, in uninfected children the sensitization to bet v1-homologues (mal d1, pru p1, cor a1, ara h8) is most common. Conclusions: the epidemiological data on the effect of the Opisthorchis felineus invasion on mechanisms of food sensitization in children were obtained.

About the authors

L. M. Ogorodova

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: lm-ogorodova@mail.ru
доктор медицинских наук, профессор, член-корреспондент РАМН, заведующая кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «СибГМУ» МЗ РФ Адрес: 634050, Томск, пр-т Ленина, д. 107, тел.: (3822) 51-36-96 Россия

O. S. Fedorova

Siberian State Medical University, Tomsk, Russian Federation

Email: olga.sergeevna.fedorova@gmail.com
доктор медицинских наук, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «СибГМУ» МЗ РФ
Адрес: 634050, Томск, пр-т Ленина, д. 107, тел.: (3822) 51-36-96 Россия

M. M. Fedotova

Siberian State Medical University, Tomsk, Russian Federation

Email: fedotova.letter@mail.ru

аспирант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «СибГМУ» МЗ РФ
Адрес: 634050, Томск, пр-т Ленина, д. 107, тел.: (3822) 51-36-96

Россия

T. A. Evdokimova

Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation

Email: et2005@yandex.ru

кандидат медицинских наук, ассистент кафедры питания детей и подростков ГБОУ ДПО «РМАПО» МЗ РФ
Адрес: 123995, Москва, ул. Баррикадная, д. 2/1, тел.: (495) 959-86-96

Россия

References

  1. NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States. J. Allergy Clin. Immunol. 2010; 126 (6): 1–58.
  2. Eigenmann P.A. Mechanisms of food allergy. Pediatr. Allergy Immunol. 2009; 20 (1): 5–11.
  3. Be rin M.C., Sampson H.A. Food allergy: an enigmatic epidemic. Trends Immunol. 2013; 34 (8): 390–397.
  4. Огородова Л.М., Фрейдин М.Б., Сазонов А.Э., Фёдорова О.С., Деев И.А., Кремер Е.Э. Влияние инвазии Opisthorchis felineus на иммунный ответ при бронхиальной астме. Бюлл. сибирской медицины. 2010; 9 (3): 85–90.
  5. Wordemann M., Diaz R.J., Heredia L.M., Collado Madurga A.M., Ruiz Esp inosa A., Prado R.C., Millan I.A., Escobedo A., Rojas Rivero L., Gryseels B., Gorbea M.B., Polman K. Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children. Trop. Med. Int. Health. 2008; 13: 180–186.
  6. Федорова О.С. Распространенность пищевой аллергии у детей в мировом очаге описторхоза. Бюлл. сибирской медицины. 2010; 9 (5): 102–107.
  7. Wong G.W., Mahesh P.A., Ogorodova L., Leung T.F., Fedorova O., Holla A.D., Fernandez-Rivas M., Clare Mills E.N., Kummeling I., van Ree R., Yazdanbakhsh M., Burney P. EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodology. Allergy. 2009; 65: 385–390.
  8. Jimenez-Lopez J.C., Gachomo E.W., Ariyo O.A., Baba-Moussa L., Kotchoni S.O. Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and foo d allergens. Mol. Biol. Rep. 2012; 39 (1): 123–130.
  9. Rujeni N., Nausch N., Bourke C.D., Midzi N., Mduluza T., Taylor D.W., Mutapi F. Atopy is inversely related to schistosome
  10. NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States. J. Allergy Clin. Immunol. 2010; 126 (6): 1–58.
  11. Eigenmann P.A. Mechanisms of food allergy. Pediatr. Allergy Immunol. 2009; 20 (1): 5–11.
  12. Be rin M.C., Sampson H.A. Food allergy: an enigmatic epidemic. Trends Immunol. 2013; 34 (8): 390–397.
  13. Огородова Л.М., Фрейдин М.Б., Сазонов А.Э., Фёдорова О.С., Деев И.А., Кремер Е.Э. Влияние инвазии Opisthorchis felineus на иммунный ответ при бронхиальной астме. Бюлл. сибирской медицины. 2010; 9 (3): 85–90.
  14. Wordemann M., Diaz R.J., Heredia L.M., Collado Madurga A.M., Ruiz Esp inosa A., Prado R.C., Millan I.A., Escobedo A., Rojas Rivero L., Gryseels B., Gorbea M.B., Polman K. Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children. Trop. Med. Int. Health. 2008; 13: 180–186.
  15. Федорова О.С. Распространенность пищевой аллергии у д е тей в мировом очаге описторхоза. Бюлл. сибирской медицины. 2010; 9 (5): 102–107.
  16. Wong G.W., Mahesh P.A., Ogorodova L., Leung T.F., Fedorova O., Holla A.D., Fernandez-Rivas M., Clare Mills E.N., Kummeling I., van Ree R., Yazdanbakhsh M., Burney P. EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodology. Allergy. 2009; 65: 385–390.
  17. Jimenez-Lopez J.C., Gachomo E.W., Ariyo O.A., Baba-Moussa L., Kotchoni S.O. Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and foo d allergens. Mol. Biol. Rep. 2012; 39 (1): 123–130.
  18. Rujeni N., Nausch N., Bourke C.D., Midzi N., Mduluza T., Taylor D.W., Mutapi F. Atopy is inversely related to schistosome

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