EFFICIENCY AND SAFETY OF HUMAN MONOCLONAL ANTIBODIES TO TNF-Α IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS IN PRIMARY AND SECONDARY INEFFECTIVENESS OF OTHER BIOLOGICALS
- Authors: Alexeeva E.I.1, Baranov A.A.1, Mitenko E.V.2, Bzarova T.M.2, Valieva S.I.2, Denisova R.V.2, Isaeva K.B.2, Chistyakova E.G.1, Sleptsova T.V.2, Taibulatov N.I.2, Zelikovich E.I.2, Kurilenkov G.V.2
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Affiliations:
- Scientific Center of Children’s Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
- Scientific Center of Children’s Health, Moscow, Russian Federation
- Issue: Vol 68, No 11 (2013)
- Pages: 73-82
- Section: SHORT MESSAGES
- Published:
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/126
- DOI: https://doi.org/10.15690/vramn.v68i11.847
- ID: 126
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Full Text
Abstract
Results: Efficacy was assessed during 1 year in 68 and 2 years - in 56 patients . At the 24th week we observed the improvement by criteria AKR in 100 , 91 and 74 % of patients , respectively, and at the 52 th week - in 100 , 96 and 90 % , respectively. Inactive disease status was recorded in 55.8, 66,1 and 98.2 % of study participants after 6 months, 1 and 2 years, respectively. Remission was achieved in 55.8 and 96.4 % of patients after 1 and 2 years of observation, respectively. Conclusions: Adalimumab was effective and well tolerated by patients with primary inefficiency, partial and loss of efficiency of other biologicals. In clinical practice, patients with non-systemic JIA transition to the second TNF-α blocker can restore the biological effect of the first drug without increasing the frequency of infectious AEs.
About the authors
E. I. Alexeeva
Scientific Center of Children’s Health, Moscow, Russian FederationI.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Author for correspondence.
Email: alekatya@ya.ru
PhD, professor, Head of the Pediatric Faculty of I.M. Sechenov First MSMU, Head of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-02-97 Russian Federation
A. A. Baranov
Scientific Center of Children’s Health, Moscow, Russian FederationI.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Email: baranov@nczd.ru
academician of RAMS and RAS, PhD, professor, Director of SCCH of RAMS, Head of the Pediatric department with course of Pediatric Rheumatology of I.M. Sechenov First. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-30-87 Russian Federation
E. V. Mitenko
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: el.mitenko@yandex.ru
research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
T. M. Bzarova
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: bzarova@nczd.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
S. I. Valieva
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: valieva@nczd.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
R. V. Denisova
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: denisovarv@yandex.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
K. B. Isaeva
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: isaeva-kseniya@yandex.ru
MD, pediatrician of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
E. G. Chistyakova
Scientific Center of Children’s Health, Moscow, Russian FederationI.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Email: chistyakova@nczd.ru
MD, leading research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
T. V. Sleptsova
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: tatyanasl08@mail.ru
MD, research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation
N. I. Taibulatov
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: taibulatov@nczd.ru
MD, Head of the Department of Remedial Treatment of Children with musculoskeletal disorders of RI of Preventive Pediatrics and Remedial Treatment of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-03-69 Russian Federation
E. I. Zelikovich
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: alekatya@ya.ru
PhD, Head of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-13-62 Russian Federation
G. V. Kurilenkov
Scientific Center of Children’s Health, Moscow, Russian Federation
Email: alekatya@ya.ru
MD, leading research scientist of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499)134-13-62 Russian Federation
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