Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC12610.15690/vramn.v68i11.847SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯEFFICIENCY AND SAFETY OF HUMAN MONOCLONAL ANTIBODIES TO TNF-Α IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS IN PRIMARY AND SECONDARY INEFFECTIVENESS OF OTHER BIOLOGICALSЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ЧЕЛОВЕЧЕСКИХ МОНОКЛОНАЛЬНЫХ АНТИТЕЛ К ФНО-Α У ДЕТЕЙ С ЮВЕНИЛЬНЫМ ИДИОПАТИЧЕСКИМ АРТРИТОМ ПРИ ПЕРВИЧНОЙ И ВТОРИЧНОЙ НЕЭФФЕКТИВНОСТИ ДРУГИХ БИОЛОГИЧЕСКИХ ПРЕПАРАТОВAlexeevaE. I.АлексееваЕ. И.
Russian Federation

PhD, professor, Head of the Pediatric Faculty of I.M. Sechenov First MSMU, Head of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-02-97

alekatya@ya.ruBaranovA. A.БарановА. А.
Russian Federation

academician of RAMS and RAS, PhD, professor, Director of SCCH of RAMS, Head of the Pediatric department with course of Pediatric Rheumatology of I.M. Sechenov First. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-30-87

baranov@nczd.ruMitenkoE. V.МитенкоЕ. В.
Russian Federation

research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

el.mitenko@yandex.ruBzarovaT. M.БзароваТ. М.
Russian Federation

MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

bzarova@nczd.ruValievaS. I.ВалиеваС. И.
Russian Federation

MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

valieva@nczd.ruDenisovaR. V.ДенисоваР. В.
Russian Federation

MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

denisovarv@yandex.ruIsaevaK. B.ИсаеваК. Б.
Russian Federation

MD, pediatrician of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

isaeva-kseniya@yandex.ruChistyakovaE. G.ЧистяковаЕ. Г.
Russian Federation

MD, leading research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

chistyakova@nczd.ruSleptsovaT. V.СлепцоваТ. В.
Russian Federation

MD, research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94

tatyanasl08@mail.ruTaibulatovN. I.ТайбулатовН. И.
Russian Federation

MD, Head of the Department of Remedial Treatment of Children with musculoskeletal disorders of RI of Preventive Pediatrics and Remedial Treatment of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-03-69

taibulatov@nczd.ruZelikovichE. I.ЗеликовичЕ. И.
Russian Federation

PhD, Head of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-13-62

alekatya@ya.ruKurilenkovG. V.КуриленковГ. В.
Russian Federation

MD, leading research scientist of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499)134-13-62

alekatya@ya.ruScientific Center of Children’s Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationНаучный центр здоровья детей РАМН, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва, Российская ФедерацияScientific Center of Children’s Health, Moscow, Russian FederationНаучный центр здоровья детей РАМН, Москва, Российская Федерация121120136811Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук738207082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/126

Purpose: To evaluate the safety and efficiency of adalimumab in children with severe refractory JIA with primary inefficiency, partial effect or loss of the effectiveness of other biologicals. Patients and methods: The article presents the results of the retrospective observational study of the efficacy and safety of adalimumab in 68 patients aged 10 (3, 17) years with various embodiments of JIA , with the primary inefficiency or partial or loss of the effectiveness of other biologicals. JIA diagnosis established on the basis of criteria ILAR (International League of Associations for Rheumatology). Results: Efficacy was assessed during 1 year in 68 and 2 years - in 56 patients . At the 24th week we observed the improvement by criteria AKR in 100 , 91 and 74 % of patients , respectively, and at the 52 th week - in 100 , 96 and 90 % , respectively. Inactive disease status was recorded in 55.8, 66,1 and 98.2 % of study participants after 6 months, 1 and 2 years, respectively. Remission was achieved in 55.8 and 96.4 % of patients after 1 and 2 years of observation, respectively. Conclusions: Adalimumab was effective and well tolerated by patients with primary inefficiency, partial and loss of efficiency of other biologicals. In clinical practice, patients with non-systemic JIA transition to the second TNF-α blocker can restore the biological effect of the first drug without increasing the frequency of infectious AEs.

Цель исследования: оценить безопасность и эффективность адалимумаба у детей с тяжелым рефрактерным вариантом ЮИА с первичной неэффективностью, частичным эффектом или утратой эффективности других биологических препаратов. Пациенты и методы. В статье представлены результаты ретроспективного обсервационного исследования эффективности и безопасности адалимумаба у 68 пациентов в возрасте 10 (3; 17) лет с различными вариантами ЮИА, с первичной неэффективностью, частичным эффектом или утратой эффективности других биологических препаратов. Диагноз ЮИА устанавливали на основании критериев ILAR (International League of Associations for Rheumatology). Результаты. Эффективность оценивали в течение 1 года у 68 и в течение 2 лет — у 56 пациентов. На 24-й нед было продемонстрировано улучшение по критериям AКР30,50,70 у 100, 91 и 74% пациентов, соответственно, а на 52-й нед — у 100, 96 и 90%, соответственно. Неактивный статус болезни зафиксирован у 55,8, 66,1 и 98,2% участников исследования через 6 мес, 1 и 2 года, соответственно. Ремиссия достигнута у 55,8 и 96,4% пациентов через 1 и 2 года наблюдения, соответственно. Выводы. Адалимумаб был эффективен и хорошо переносился пациентами с первичной неэффективностью, частичным эффектом и утратой эффективности других биологических препаратов. В клинической практике у пациентов с несистемным ЮИА переход на второй блокатор ФНО-α может восстановить эффект первого биологического препарата без увеличения частоты инфекционных НЯ.

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