EFFICIENCY AND SAFETY OF HUMAN MONOCLONAL ANTIBODIES TO TNF-Α IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS IN PRIMARY AND SECONDARY INEFFECTIVENESS OF OTHER BIOLOGICALS

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Abstract

Purpose: To evaluate the safety and efficiency of adalimumab in children with severe refractory JIA with primary  inefficiency,  partial effect or loss of the effectiveness of other biologicals. Patients and methods: The article presents the results of the retrospective observational study of the efficacy and safety of adalimumab in 68 patients aged 10 (3, 17) years with various embodiments of JIA , with the primary inefficiency or partial or loss of the effectiveness of other biologicals. JIA diagnosis established on the basis of criteria ILAR (International League of Associations for Rheumatology).
Results: Efficacy was assessed during 1 year in 68 and  2 years -  in 56 patients . At the 24th week we observed the  improvement by criteria AKR in 100 , 91 and 74 % of patients , respectively, and at the 52 th week - in 100 , 96 and 90 % , respectively. Inactive disease status was recorded in 55.8, 66,1 and 98.2 % of study participants after  6 months, 1 and 2 years, respectively. Remission was achieved in 55.8 and 96.4 % of patients after 1 and 2 years of observation, respectively. Conclusions: Adalimumab was effective and well tolerated by patients with primary inefficiency, partial and  loss of efficiency of other biologicals. In clinical practice, patients with non-systemic JIA transition to the second TNF-α blocker can restore the biological effect of the first drug without increasing the frequency of infectious AEs.


About the authors

E. I. Alexeeva

Scientific Center of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Author for correspondence.
Email: alekatya@ya.ru
PhD, professor, Head of the Pediatric Faculty of I.M. Sechenov First MSMU, Head of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-02-97 Russian Federation

A. A. Baranov

Scientific Center of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Email: baranov@nczd.ru
academician of RAMS and RAS, PhD, professor, Director of SCCH of RAMS, Head of the Pediatric department with course of Pediatric Rheumatology of I.M. Sechenov First. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-30-87 Russian Federation

E. V. Mitenko

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: el.mitenko@yandex.ru
research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

T. M. Bzarova

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: bzarova@nczd.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

S. I. Valieva

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: valieva@nczd.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

R. V. Denisova

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: denisovarv@yandex.ru
MD, senior research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

K. B. Isaeva

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: isaeva-kseniya@yandex.ru
MD, pediatrician of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

E. G. Chistyakova

Scientific Center of Children’s Health, Moscow, Russian Federation
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Email: chistyakova@nczd.ru
MD, leading research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

T. V. Sleptsova

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: tatyanasl08@mail.ru
MD, research scientist of the Rheumatologic Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-14-94 Russian Federation

N. I. Taibulatov

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: taibulatov@nczd.ru
MD, Head of the Department of Remedial Treatment of Children with musculoskeletal disorders of RI of Preventive Pediatrics and Remedial Treatment of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-03-69 Russian Federation

E. I. Zelikovich

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: alekatya@ya.ru
PhD, Head of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-13-62 Russian Federation

G. V. Kurilenkov

Scientific Center of Children’s Health, Moscow, Russian Federation

Email: alekatya@ya.ru
MD, leading research scientist of the X-ray Computed Tomography Department of SCCH of RAMS. Address: build. 1, 2, Lomonosovskii Avenue, Moscow, RF, 119991; tel.: +7 (499)134-13-62 Russian Federation

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