Controversial Issues of Immunopathogenesis of Psoriasis and Atopic Dermatitis

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Abstract

Psoriasis (PsO) and atopic dermatitis (AD have much in common: both diseases are widespread, characterized by a chronic relapsing course, primarily affect the skin and lead to a quality reduction of life of patients, regardless of their age. The pathogenesis of these two dermatoses, which are the most common in the practice of a pediatric dermatologist, is quite different. PsO is a chronic inflammatory skin disease, the pathogenesis of which is associated with the involvement of the Th1 pathway: Th17 cells and the IL-23/IL-17 axis. AD, in turn, is usually associated with high levels of IL-4, IL-5, IL-13, IL-31 and IFN-γ produced by activated T-helper 2 (Th2) cells. The clinical symptoms and immunopathological responses of these two skin conditions tend to differ. However, patients with PsO may sometimes present with a skin rash resembling AD combined with intense itching and laboratory increase in immunoglobulin E (IgE) which may indicate the need to change the paradigm of dominance of only one type of T-inflammation in patients with these diseases.

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About the authors

Eduard T. Ambarchian

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery

Author for correspondence.
Email: edo_amb@mail.ru
ORCID iD: 0000-0002-8232-8936

MD, PhD

Russian Federation, Moscow

Leila S. Namazova-Baranova

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: leyla.s.namazova@gmail.com
ORCID iD: 0000-0002-2209-7531

MD, PhD, Professor, Academician of the RAS

Russian Federation, Moscow; Moscow

Anastasiia D. Kuzminova

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery

Email: kuzminova_derma@mail.ru
ORCID iD: 0000-0003-3003-9398

MD

Russian Federation, Moscow

Vladislav V. Ivanchikov

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery

Email: awdawd22@yandex.ru
ORCID iD: 0000-0002-6760-3119

MD

Russian Federation, Moscow

Elena A. Vishneva

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: vishneva.e@yandex.ru
ORCID iD: 0000-0001-7398-0562

MD, PhD, Professor of the RAS

Russian Federation, Moscow; Moscow

Marika I. Ivardava

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery

Email: makussa@mail.ru
ORCID iD: 0000-0002-4669-9510

MD, Phd

Russian Federation, Moscow

Kamilla E. Efendiyeva

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: kamillaef@inbox.ru
ORCID iD: 0000-0003-0317-2425

MD, PhD, Associate Professor

Russian Federation, Moscow; Moscow

Juliya G. Levina

Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: julia.levina@mail.ru
ORCID iD: 0000-0002-2460-7718

MD, PhD, Associate Professor

Russian Federation, Moscow; Moscow

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2. Рис. 1. Иммунопатогенез атопического дерматита, псориаза и их перекреста (адаптировано по: [50]): АтД — атопический дерматит; ПсО — псориаз; PsEma — перекрест атопического дерматита и псориаза

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