Overweight and Obesity in Children as Predictors of Early Puberty: A Meta-Analysis

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Abstract

Background. Obesity and overweight among children remains to be an actual problem. To date, the relationship between them and puberty has not been determined. Objective — to estimate the overweight and obesity impact on puberty in boys and girls.

Methods. The search for relevant sources was carried out in the Medline/PubMed, Researchgate, Elibrary, www.clinicaltrials.gov, www.clinicaltrialresults.org databases for the period from 2000 to 2023. Nine studies with a total of 24, 542 participants aged 0 to 18 years were selected for inclusion in the meta-analysis.

Results. A significant relationship was established between precocious puberty in overweight/obese girls OR 2.23 (CI 1.63–3.05; p < 0.00001) and a tendency to accelerated puberty in boys OR 1.43 (CI 0.92–2.23; p = 0.11).

Conclusion. Overweight and obesity in children are determinants of faster rates of puberty, in particular among girls.

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About the authors

Olga P. Kovtun

Ural State Medical University

Email: usma@usma.ru
ORCID iD: 0000-0002-5250-7351
SPIN-code: 9919-9048
Scopus Author ID: 23980378200

MD, PhD, Professor, Academician of the RAS

Russian Federation, 3 Repina str., 620028, Yekaterinburg

Tatyana O. Brodovskaya

Ural State Medical University

Author for correspondence.
Email: tbrod80@gmail.com
ORCID iD: 0000-0002-2847-4422
SPIN-code: 7798-7054
Scopus Author ID: 57203961225

MD, PhD, Associate Professor

Russian Federation, 3 Repina str., 620028, Yekaterinburg

Margarita A. Ustyuzhanina

Ural State Medical University

Email: ustmargarita@mail.ru
ORCID iD: 0000-0002-4285-6902
SPIN-code: 5438-4476

MD, PhD, Associate Professor]

Russian Federation, 3 Repina str., 620028, Yekaterinburg

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Supplementary files

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2. Fig.1. Study design

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3. Fig.2. Results of a meta-analysis on the effect of overweight/obesity on puberty in girlsy in girls

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4. Fig.3. Funnel plot assessing the risk of publication bias of the effect of overweight/obesity on puberty in girls

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5. Fig.4. Results of a meta-analysis on the effect of overweight/obesity on puberty in European girls

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6. Fig.5. Funnel plot assessing the risk of publication bias of the effect of overweight/obesity on puberty in European girls

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7. Fig.6. Results of a meta-analysis on the effect of overweight/obesity on puberty in Chinese girls

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8. Fig. 7. Funnel plot risk assessment of publication bias on the impact of overweight/obesity on puberty in North American girls

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9. Fig.8. Results of a meta-analysis on the effects of overweight/obesity on puberty in North American girls

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10. Fig.9. Funnel plot assessing the risk of publication bias of the effect of overweight/obesity on puberty in North American girls

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11. Fig. 10. Results of a meta-analysis of the effect of overweight/obesity on puberty in boys

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12. Fig. 11. Funnel plot assessing the risk of publication bias of overweight/obesity at puberty in boys

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13. Fig. 12. Results of a meta-analysis of the effect of overweight/obesity on puberty in boys in Europe and North America

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14. Fig. 13. Funnel plot assessing the risk of publication bias of the effect of overweight/obesity on puberty in boys in Europe and North America

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15. Fig. 14. Results of a meta-analysis of the effects of overweight/obesity on puberty in Chinese boys

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16. Fig. 15. Funnel plot assessing the risk of publication bias of the effect of overweight/obesity on puberty in Chinese boys

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