Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC881010.15690/vramn8810PEDIATRICS: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПЕДИАТРИИResearch ArticleOverweight and Obesity in Children as Predictors of Early Puberty: A Meta-AnalysisИзбыточная масса тела и ожирение у детей как предикторы раннего полового созревания: метаанализhttps://orcid.org/0000-0002-5250-7351239803782009919-9048KovtunOlga P.КовтунОльга Петровна
Russian Federation

MD, PhD, Professor, Academician of the RAS

доктор медицинских наук, профессор, академик РАН

usma@usma.ruhttps://orcid.org/0000-0002-2847-4422572039612257798-7054BrodovskayaTatyana O.БродовскаяТатьяна Олеговна
Russian Federation

MD, PhD, Associate Professor

доктор медицинских наук, доцент

tbrod80@gmail.comhttps://orcid.org/0000-0002-4285-69025438-4476UstyuzhaninaMargarita A.УстюжанинаМаргарита Александровна
Russian Federation

MD, PhD, Associate Professor]

кандидат медицинских наук, доцент

ustmargarita@mail.ruUral State Medical UniversityУральский государственный медицинский университет1501202479160691407202301122023Copyright ©; 2024, "Paediatrician" Publishers LLCCopyright ©; 2024, Издательство "Педиатръ"2024"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/8810

Background. Obesity and overweight among children remains to be an actual problem. To date, the relationship between them and puberty has not been determined. Objective — to estimate the overweight and obesity impact on puberty in boys and girls.

Methods. The search for relevant sources was carried out in the Medline/PubMed, Researchgate, Elibrary, www.clinicaltrials.gov, www.clinicaltrialresults.org databases for the period from 2000 to 2023. Nine studies with a total of 24, 542 participants aged 0 to 18 years were selected for inclusion in the meta-analysis.

Results. A significant relationship was established between precocious puberty in overweight/obese girls OR 2.23 (CI 1.63–3.05; p < 0.00001) and a tendency to accelerated puberty in boys OR 1.43 (CI 0.92–2.23; p = 0.11).

Conclusion. Overweight and obesity in children are determinants of faster rates of puberty, in particular among girls.

Обоснование. Ожирение и избыточная масса тела среди детей остаются актуальной проблемой системы здравоохранения. До настоящего времени не определена связь данной патологии с темпом полового созревания. Цель — выявить отдельные закономерности формирования преждевременного полового созревания у мальчиков и девочек с избыточной массой тела и ожирением.

Методы. Поиск релевантных источников проведен в базах Medline/PubMed, Researchgate, Elibrary, www.clinicaltrials.gov, www.clinicaltrialresults.org за период с 2000 по 2023 г. Для включения в метаанализ отобрано 9 исследований с общим количеством наблюдений 24 542 детей в возрасте от 0 до 18 лет.

Результаты. Установлена значимая взаимосвязь между преждевременным половым созреваниям у девочек с избыточной массой тела / ожирением OR 2,23 (CI 1,63–3,05; p < 0,00001) и тенденция к ускоренному пубертату у мальчиков OR 1,43 (CI 0,92–2,23; p = 0,11).

Заключение. Избыточная масса тела и ожирение у детей являются детерминантами опережающего темпа полового созревания, в частности, среди девочек.

obesityoverweightchildrenadolescentspubertyожирениелишний весдетиподросткипубертатУральский государственный медицинский университетUral State Medical UniversityOgden CL, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA. 2012;307(5):483–490. doi: https://doi.org/10.1001/jama.2012.40Ji CY, Chen TJ. Empirical changes in the prevalence of overweight and obesity among Chinese students from 1985 to 2010 and corresponding preventive strategies. Biomed Environ Sci. 2013;26(1):1–12. doi: https://doi.org/10.3967/0895-3988.2013.01.001Дедов И.И., Мельниченко Г.А., Чеботникова Т.В., и др. Половое развитие детей и подростков Московского региона: влияние ожирения // Русский медицинский журнал. — 2006. — № 26. — С. 1872. [Dedov II, Melnichenko GA, Chebotnikova TV, et al. Puberty in children and adolescents in the Moscow region: the impact of obesity. Russian Medical Journal. 2006;26:1872. (In Russ.)]Sun H, Ma Y, Han D, et al. Prevalence and trends in obesity among China’s children and adolescents, 1985–2010. PLoS One. 2014;9(8):e105469. doi: https://doi.org/10.1371/journal.pone.0105469Ogden CL, Carroll MD, Kit BK, et al. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806–814. doi: https://doi.org/10.1001/jama.2014.732Han JC, Lawlor DA, Kimm SY. Childhood obesity. Lancet. 2010;375(9727):1737–1748. doi: https://doi.org/10.1016/S0140-6736(10)60171-7O’Keeffe LM, Frysz M, Bell JA, et al. Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence. Hum Reprod. 2020;35(12):2784–2792. doi: https://doi.org/10.1093/humrep/deaa213Denzer C, Weibel A, Muche R, et al. Pubertal development in obese children and adolescents. Int J Obes (Lond). 2007;31(10):1509–1519. doi: https://doi.org/10.1038/sj.ijo.0803691Davison KK, Susman EJ, Birch LL. Percent body fat at age five predicts earlier pubertal development among girls at age 9. Pediatrics. 2003;111(4 Pt 1):815–821. doi: https://doi.org/10.1542/peds.111.4.815Silventoinen K, Haukka J, Dunkel L, et al. Genetics of pubertal timing and its associations with relative weight in childhood and adult height: the Swedish young male twins study. Pediatrics. 2008;121(4):e885–e891. doi: https://doi.org/10.1542/peds.2007-1615Lee JM, Kaciroti N, Appugliese D, et al. Body mass index and timing of pubertal initiation in boys. Arch Pediatr Adolesc Med. 2010;164(2):139–144. doi: https://doi.org/10.1001/archpediatrics.2009.258Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics. 2002;110(5):903–910. doi: https://doi.org/10.1542/peds.110.5.903Chen YC, Fan HY, Yang C, et al. Assessing causality between childhood adiposity and early puberty: a bidirectional Mendelian randomization and longitudinal study. Metabolism. 2019;100:153961. doi: https://doi.org/10.1016/j.metabol.2019.153961Chen C, Zhang Y, Sun W, et al. Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China. BMJ Open. 2017;7(4):e014004. doi: https://doi.org/10.1136/bmjopen-2016-014004Flom JD, Cohn BA, Tehranifar P, et al. Earlier age at menarche in girls with rapid early life growth: cohort and within sibling analyses. Ann Epidemiol. 2017;27(3):187–193.e2. doi: https://doi.org/10.1016/j.annepidem.2017.01.004He F, Guan P, Liu Q, et al. The relationship between obesity and body compositions with respect to the timing of puberty in Chongqing adolescents: a cross-sectional study. BMC Public Health. 2017;17(1):664. doi: https://doi.org/10.1186/s12889-017-4681-1Zhai L, Liu J, Zhao J, et al. Association of Obesity with Onset of Puberty and Sex Hormones in Chinese Girls: A 4-Year Longitudinal Study. PLoS One. 2015;10(8):e0134656. doi: https://doi.org/10.1371/journal.pone.0134656Leitao RB, Rodrigues LP, Neves L, et al. Development of adiposity, obesity and age at menarche: An 8-year follow-up study in Portuguese schoolgirls. Int J Adolesc Med Health. 2013;25(1):55–63. doi: https://doi.org/10.1515/ijamh-2013-0007Tremblay L, Frigon JY. The interaction role of obesity and puberty timing on the psychosocial adjustment of adolescent girls: Longitudinal data. Int J Obes (Lond). 2005;29(10):1204–1211. doi: https://doi.org/10.1038/sj.ijo.0803021Kuczmarski R, Ogden C, Grummer-Strawn L, et al. CDC growth charts: United States. Adv Data. 2000;314:1–27.de Ridder CM, Thijssen JH, Bruning PF, et al. Body fat mass, body fat distribution, and pubertal development: a longitudinal study of physical and hormonal sexual maturation of girls. J Clin Endocrinol Metab. 1992;75(2):442–446. doi: https://doi.org/10.1210/jcem.75.2.1639945Ahmed ML, Ong KK, Dunger DB. Childhood obesity and the timing of puberty. Trends EndocrinolMetab. 2009:20(5):237–242. doi: https://doi.org/10.1016/j.tem.2009.02.004Nieuwenhuis D, Pujol-Gualdo N, Arnoldussen IAC, et al. Adipokines: A gear shift in puberty. Obes Rev. 2020;21(6):e13005. doi: https://doi.org/10.1111/obr.13005Mathew H, Castracane VD, Mantzoros C. Adipose tissue and reproductive health. Metabolism. 2018;86:18–32. doi: https://doi.org/10.1016/j.metabol.2017.11.006Michalakis K, Mintziori G, Kaprara A, et al. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism. 2013;62(4):457–478. doi: https://doi.org/10.1016/j.metabol.2012.08.012Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update. 2014;20(2):153–174. doi: https://doi.org/10.1093/humupd/dmt033