The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction

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Abstract


It is established that oxidative stress induces insulin resistance of adipocytes, increases secretion leptin, IL-6, TNF-α by adipocytes. Adiponectin secretion by adipocytes is reduced after the action of reactive oxygen species. Metabolic syndrome contributes to oxidative stress in adipose tissue, on the one hand due to the activation of production of reactive oxygen species by adipocyte NADPH-oxidase, and on the other hand by reducing the antioxidant defense adipocytes. It is found that obesity itself can induce oxidative stress. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α play an important role in the pathogenesis of oxidative stress of adipocytes. Metformin remains the cure for the treatment of insulin resistance. The positive results in the treatment of metabolic syndrome by losartan were obtained. Antioxidants and flavonoids exhibit a positive impact on the course of the experimental metabolic syndrome.

E. S. Prokudina

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: goddess27@mail.ru
ORCID iD: 0000-0002-1991-6516

Russian Federation

Младший научный сотрудник лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111

SPIN-код: 3819-7464

L. N. Maslov

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences

Author for correspondence.
Email: maslov@cardio-tomsk.ru
ORCID iD: 0000-0002-6020-1598

Доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии. 

Адрес: 634012, Томск, ул. Киевская, д. 111

SPIN-код5843-2490


V. V. Ivanov

Siberian State Medical University

Email: ivanovvv1953@gmail.com
ORCID iD: 0000-0001-9348-4945

Кандидат биологических наук, руководитель лаборатории биомоделей.

Адрес: 634050, Томск, Московский тракт, д. 2

SPIN-код: 4961-9959

I. D. Bespalova

Siberian State Medical University

Email: innadave@mail2000.ru
ORCID iD: 0000-0002-1053-4781

Кандидат медицинских наук, заведующая кафедрой социальной работы, социальной и клинической психологии.

Адрес: 634050, Томск, Московский тракт, д. 2.

SPIN-код6852-6200

D. S. Pismennyi

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: Cross_117@mail.ru
ORCID iD: 0000-0002-4751-8953

Лаборант-исследователь лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111.

SPIN-код: 7441-0790

N. S. Voronkov

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: maslov@cardio-tomsk.ru
ORCID iD: 0000-0002-9447-4236

Лаборант-исследователь лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111. 

SPIN-код: 7862-7013

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