Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC79810.15690/vramn798BIOCHEMISTRY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ БИОХИМИИThe Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological CorrectionРоль активных форм кислорода в патогенезе дисфункции адипоцитов при метаболическом синдроме: перспективы фармакологической коррекцииhttps://orcid.org/0000-0002-1991-6516ProkudinaE. S.ПрокудинаЕкатерина Сергеевна
Russian Federation

Младший научный сотрудник лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111

SPIN-код: 3819-7464

goddess27@mail.ruhttps://orcid.org/0000-0002-6020-1598MaslovL. N.МасловЛеонид Николаевич

Доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111

SPIN-код: 5843-2490

maslov@cardio-tomsk.ruhttps://orcid.org/0000-0001-9348-4945IvanovV. V.ИвановВладимир Владимирович

Кандидат биологических наук, руководитель лаборатории биомоделей.

Адрес: 634050, Томск, Московский тракт, д. 2

SPIN-код: 4961-9959

ivanovvv1953@gmail.comhttps://orcid.org/0000-0002-1053-4781BespalovaI. D.БеспаловаИнна Давидовна

Кандидат медицинских наук, заведующая кафедрой социальной работы, социальной и клинической психологии.

Адрес: 634050, Томск, Московский тракт, д. 2.

SPIN-код: 6852-6200

innadave@mail2000.ruhttps://orcid.org/0000-0002-4751-8953PismennyiD. S.ПисьменныйДмитрий Сергеевич

Лаборант-исследователь лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111.

SPIN-код: 7441-0790

Cross_117@mail.ruhttps://orcid.org/0000-0002-9447-4236VoronkovN. S.ВоронковНикита Сергеевич

Лаборант-исследователь лаборатории экспериментальной кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111.

SPIN-код: 7862-7013

maslov@cardio-tomsk.ruCardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of SciencesНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукSiberian State Medical UniversityСибирский государственный медицинский университет0803201772111162801201715022017Copyright ©; 2017, "Paediatrician" Publishers LLCCopyright ©; 2017, Издательство "Педиатръ"2017"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/798

It is established that oxidative stress induces insulin resistance of adipocytes, increases secretion leptin, IL-6, TNF-α by adipocytes. Adiponectin secretion by adipocytes is reduced after the action of reactive oxygen species. Metabolic syndrome contributes to oxidative stress in adipose tissue, on the one hand due to the activation of production of reactive oxygen species by adipocyte NADPH-oxidase, and on the other hand by reducing the antioxidant defense adipocytes. It is found that obesity itself can induce oxidative stress. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α play an important role in the pathogenesis of oxidative stress of adipocytes. Metformin remains the cure for the treatment of insulin resistance. The positive results in the treatment of metabolic syndrome by losartan were obtained. Antioxidants and flavonoids exhibit a positive impact on the course of the experimental metabolic syndrome.

Установлено, что окислительный стресс вызывает инсулинорезистентность адипоцитов, способствует увеличению секреции адипоцитами лептина, ИЛ-6, ФНО-α. Под действием активных форм кислорода снижается секреция адипоцитами адипонектина. Метаболический синдром способствует окислительному стрессу в жировой ткани с одной стороны – за счет активации продукции активных форм кислорода НАДФН-оксидазой, а с другой – в результате снижения антиоксидантной защиты адипоцитов. Установлено, что ожирение само по себе может вызывать окислительный стресс. В патогенезе окислительного стресса адипоцитов важную роль играет хронический стресс, глюкокортикоиды, минералокортикоиды, ангиотензин-II, ФНО-α. Средством выбора при лечении инсулинорезистентности остаётся метформин. Получены положительные результаты при лечении метаболического синдрома лозартаном. Антиоксиданты и флавоноиды оказывают положительное влияние на течение экспериментального метаболического синдрома.

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