BILIARY MICROBIOTA AND BILE DUCT DISEASES

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Abstract

Traditionally, the biliary tract has been considered to be normally sterile, and the presence of microorganisms in bile is a marker of a pathological process. This assumption was confirmed by failure in allocation of bacterial strains from the normal bile duct. The paper provides rationale for a phenomenon of the normal biliary microbiota as a separate functional layer which protects a biliary tract from colonization by exogenous microorganisms. We revealed the potential of metagenomic data for prevention of infectious diseases, post-operative complications of reconstructive interventions including bile duct stenting and implantation the tissue-engineered structures exposed to the risks of colonization with pathogenic / exogenous microorganisms. The methods based on preserving homeostasis of normal biliary microbiota ecosystem can be used for prevention of hepatobiliary diseases and treatment of biliary tract inflammatory diseases.

About the authors

I. D. Klabukov

Sechenov First Moscow State Medical University, Institute for Regenerative Medicine

Author for correspondence.
Email: ilya.klabukov@gmail.com
ORCID iD: 0000-0002-2888-7999

Научный сотрудник отдела передовых клеточных технологий.

119991, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00.

SPIN-код: 3388-8859

Россия

A. V. Lyundup

Sechenov First Moscow State Medical University, Institute for Regenerative Medicine

Email: lyundup@gmail.com
ORCID iD: 0000-0002-0102-5491

Кандидат медицинских наук, заведующий отделом передовых клеточных технологий Института регенеративной медицины.

119991, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00.

SPIN-код: 4954-3004

Россия

T. G. Dyuzheva

Sechenov First Moscow State Medical University, Institute for Regenerative Medicine

Email: dtg679@gmail.com
ORCID iD: 0000-0003-0573-7573

Доктор медицинских наук, профессор, заведующая отделом регенеративной хирургии печени и поджелудочной железы.

119991, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00.

SPIN-код: 7325-2086

Россия

A. V. Tyakht

Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Email: a.tyakht@gmail.com
ORCID iD: 0000-0002-7358-2537
Moscow Россия

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