Prospects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical Data

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Abstract


An antagonist of central cannabinoid CB1 receptors rimonabant causes weight loss in patients with obesity and metabolic syndrome, improves blood lipid parameters, increases the adiponectin level, decreases the rate of glucose and glycosylated hemoglobin in patients with diabetes mellitus
type-2. However, rimonabant adverse effects include depression, anxiety, nausea, and dizziness which are apparently due to the blockade of central CB1 receptors. In mice with a high-calorie diet, we defined that the blockade of peripheral CB1 receptors prevents obesity, steatosis of the liver, improves lipid and carbohydrate metabolism. Experimental studies suggest that peripheral CB2 receptor agonists have antiatherogenic effect. To validate the expediency of clinical research of CB2 receptor agonists in patients with atherosclerosis the comparative analysis of antiatherogenic properties of cannabinoids should be performed. In addition, experiments are needed on the combination use of cannabinoids with well-known antiatherogenic agents, such as statins.

L. N. Maslov

Tomsk National Research Medical Centre, Russian Academy of Sciences

Author for correspondence.
Email: maslov@cardio-tomsk.ru
ORCID iD: 0000-0002-6020-1598

Russian Federation

Доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 5843-2490

R. S. Karpov

Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: tvk@cardio-tomsk.ru
ORCID iD: 0000-0002-7011-4316

Доктор медицинских наук, профессор, академик РАН, научный руководитель Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 8263-2641

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