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Вестник Российской академии медицинских наук

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Перспективы использования лигандов каннабиноидных рецепторов для лечения метаболического синдрома и атеросклероза: анализ экспериментальных и клинических данных

https://doi.org/10.15690/vramn779

Полный текст:

Аннотация

Антагонист центральных каннабиноидных СВ1-рецепторов римонабант вызывает снижение массы тела у пациентов с ожирением и метаболическим синдромом, улучшает липидные показатели крови, увеличивает уровень адипонектина, снижает уровень гликилированного гемоглобина и глюкозы у пациентов с сахарным диабетом 2-типа. Однако римонабант способствует возникновению депрессии, беспокойства, тошноты и головокружения, по-видимому, за счёт блокады центральных СВ1-рецепторов. Установлено, что у мышей, находящихся на высококалорийной диете, блокада периферических СВ1-рецепторов препятствует ожирению, стеатозу печени, улучшает показатели липидного и углеводного обмена. Экспериментальные исследования свидетельствуют, что агонисты периферических СВ2-рецепторов оказывают антиатерогенный эффект. Однако для решения вопроса о целесообразности клинических испытаний агонистов СВ2-рецепторов у пациентов с атеросклерозом необходим сравнительный анализ антиатерогенных свойств каннабиноидов. Кроме того, необходимы эксперименты по совместному применению каннабиноидов и известных антиатерогенных препаратов, например, статинов. 

Об авторах

Леонид Николаевич Маслов
Томский национальный исследовательский медицинский центр Российской академии наук
Россия

Доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 5843-2490



Ростислав Сергеевич Карпов
Томский национальный исследовательский медицинский центр Российской академии наук

Доктор медицинских наук, профессор, академик РАН, научный руководитель Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 8263-2641



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Для цитирования:


Маслов Л.Н., Карпов Р.С. Перспективы использования лигандов каннабиноидных рецепторов для лечения метаболического синдрома и атеросклероза: анализ экспериментальных и клинических данных. Вестник Российской академии медицинских наук. 2017;72(1):59-65. https://doi.org/10.15690/vramn779

For citation:


Maslov L.N., Karpov R.S. Prospects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical Data. Annals of the Russian academy of medical sciences. 2017;72(1):59-65. (In Russ.) https://doi.org/10.15690/vramn779

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