Disorders of Protein Conformation as a Typical Component of Various Human Disease Pathogenesis

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Abstract

The review is aimed to analyze the data of the recent studies and to describe all the disorders of protein conformation as a typical pathogenic process of protein structure and metabolism involved in various human disease pathogenesis. The existing group of the disorders of protein metabolism doesn’t clearly reflect the involvement of misfolding in the pathogenesis of many human diseases (as a significant factor) and the term disproteinosis is being broadly used only in the context of some «typical» protein misfolding diseases or conformational diseases (for example, amyloidosis and sickle cell anemia). However, protein conformational stability disorders are well-described as physico-chemical processes; there are diseases, in which the manifestations of protein disorders reach their maximum. The revealing of universal form of conformational stability pathology may eliminate the gaps in the understanding of many human diseases, including some diseases with high social significance. 

About the authors

V. N. Sakharov

I.M. Sechenov First Moscow State Medical University, Moscow

Author for correspondence.
Email: vladimirsah91@mail.ru
MD, PhD student Россия

P. F. Litvitskiy

I.M. Sechenov First Moscow State Medical University, Moscow

Email: litvicki@mma.ru
MD, PhD, Professor Россия

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